Abstract
Background and aim: Preterm infants have a high incidence of brain lesions that may lead to long-term disabilities. Early diagnosis of cerebral ischemia and hemorrhage may enable protection of the brain by prevention or neuroprotective treatment. Our recently developed time-domain near-infrared optical tomography (TD NIROT) system provides images to diagnose neonatal brain injury. Our aim is to study the image quality achievable from the TD NIROT signals perturbed by noise for two common cases: ischemia and hemorrhage. Methods: We implemented simulations on a spherical model of diameter 60 mm representing a typical neonatal head where the absorption μa = 0.08 cm−1 and the reduced scattering μ′s = 4.1 cm−1. Injury-mimicking spherical inclusions of various diameters (1 ~ 10 mm) were placed at depths of 10 ~ 20 mm in the ischemia case (2.5 × μa) and 14 ~ 30 mm for the hemorrhage case (50 × μa). TD data were generated from a large number of source-detector pairs, i.e., 208 detectors placed within a circle of diameter 40 mm on the surface surrounded by 18 sources. Up to 5% Gaussian noise was added in the simulations. 3D images were reconstructed with the modified Tikhonov minimization with the initial guess of a homogeneous phantom, and the images were evaluated by positional error and Dice similarity. Results: The inclusions were localized correctly with low positional errors (<1 mm), and the segmented images share a high Dice similarity with the ground truth for both the ischemia and the hemorrhage case, even for tiny inclusions of 1 mm in deep tissue. The hemorrhage case with a high contrast tolerates a substantial level of noise even though the performance drops with higher noise as expected. Conclusions: The large amount of data provided by our novel TD NIROT system provides rich enough information for correctly locating hemorrhage and ischemia in the neonatal brain.
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References
Wolf M, Bucher HU, Dietz V et al (1997) How to evaluate slow oxygenation changes to estimate absolute cerebral haemoglobin concentration by near infrared spectrophotometry in neonates. Adv Exp Med Biol 411(495–501):1997
Arri S, Muehlemann T, Biallas M et al (2011) Precision of cerebral oxygenation and hemoglobin concentration measurements inneonates measured by near-infrared spectroscopy. J Biomed Opt 16(4):047005
Jiang J, Wolf M, Sánchez Majos S (2017) Fast reconstruction of optical properties for complex segmentations in near infrared imaging. J Mod Opt 64(7):732
Di Costanzo-Mata A, Jiang J, Lindner S et al Time-resolved NIROT ‘Pioneer’ system for imaging the oxygenation of the preterm brain (accepted ISOTT 2018)
Lindner S, Zhang C, Antolovic IM et al (2018) A novel 32× 32, 224 Mevents/s time resolved SPAD image sensor for near-infrared optical tomography, Optics and the Brain, JTh5A. 6. Optical Society of America
Dehghani H, Eames ME, Yalavarthy PK et al (2009) Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction. Commun Numer Methods Eng 25:711–732
Jermyn M, Ghadyani H, Mastanduno MA et al (2013) Fast segmentation and high-quality three-dimensional volume mesh creation from medical images for diffuse optical tomography. J Biomed Opt 18(8):086007
Acknowledgments
This research was supported by the Swiss Cancer Research grant KFS-3732-08-2015, the Swiss National Science Foundation project 159490, and CONACyT by the CVU-627802.
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Jiang, J., Di Costanzo Mata, A., Lindner, S., Wolf, M., Kalyanov, A. (2021). Localization of Deep Ischemia and Hemorrhage in Preterm Infants’ Head with Near-Infrared Optical Tomography: A Numerical Case Study. In: Nemoto, E.M., Harrison, E.M., Pias, S.C., Bragin, D.E., Harrison, D.K., LaManna, J.C. (eds) Oxygen Transport to Tissue XLII. Advances in Experimental Medicine and Biology, vol 1269. Springer, Cham. https://doi.org/10.1007/978-3-030-48238-1_21
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DOI: https://doi.org/10.1007/978-3-030-48238-1_21
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