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Perioperative Antifibrinolytics and Coagulation Management

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Evidence-Based Practice in Perioperative Cardiac Anesthesia and Surgery

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Abstract

Post-cardiopulmonary bypass coagulopathy is a common and important cause of patient morbidity after cardiac surgery. In most patients, the aetiology is multifactorial and can involve platelet defects, coagulation factor deficiencies, and increased fibrinolysis. Now a better understanding of the coagulation cascade along with improvements in coagulation testing modalities has led to the refinement of blood transfusion protocols and guides the use of other therapeutic adjuncts. Timely treatment of perioperative bleeding and optimal blood management is vitally important to improving postoperative outcomes for patients undergoing cardiac surgery.

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Authors and Affiliations

  1. Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada

    John Fitzgerald, Aidan Sharkey & Keyvan Karkouti

Authors
  1. John Fitzgerald
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  2. Aidan Sharkey
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  3. Keyvan Karkouti
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Corresponding author

Correspondence to Keyvan Karkouti .

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Editors and Affiliations

  1. Distinguished University Professor Department of Anesthesia and Perioperative Medicine and Department of MedicineDivision of Critical Care Medicine, London Health Sciences Center and St Joseph’s Healthcare London Centre for Medical Evidence, Decision Integrity and Clinical Impact (MEDICI) Western University, London, ON, Canada

    Davy C.H. Cheng

  2. Associate Professor Department of Anesthesia and Perioperative Medicine and Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Centre for Medical Evidence, Decision Integrity and Clinical Impact (MEDICI) Western University, London, ON, Canada

    Janet Martin

  3. Professor of Surgery University of Toronto, Melanie Munk Chair of Cardiovascular Surgery University Health Network, Toronto, ON, Canada

    Tirone David

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Fitzgerald, J., Sharkey, A., Karkouti, K. (2021). Perioperative Antifibrinolytics and Coagulation Management. In: Cheng, D.C., Martin, J., David, T. (eds) Evidence-Based Practice in Perioperative Cardiac Anesthesia and Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-47887-2_24

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  • DOI: https://doi.org/10.1007/978-3-030-47887-2_24

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-47886-5

  • Online ISBN: 978-3-030-47887-2

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