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Neuroplasticity and Other Treatment Options for Cognitive and Behavioral Neurological Syndromes

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Clinical Mentation Evaluation

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Abstract

It would be a remiss not to have a section enunciating potential treatments of the several hundred cognitive and behavioral syndromes mentioned in the foregoing chapters. There has been renewed focus on working with the brain’s inherent neuroplasticity, which has been relatively ignored until recently. The predominant focus over the past few decades has been on neuropharmacological or pill-centric approaches. Furthermore, we have also had a gene-centric approach that had been initially promising since the recently completed Human Genome Project. This too has given way to the epigenetic and small RNA science from direct environmental influences. Finally, due to a memory-centric culture over the past few decades, much of clinical dementia and mild cognitive impairment may have been obscured by other important symptoms and dementias other than Alzheimer’s disease.

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References

  1. Xie L, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342:373–377 and underwood E. sleep: the Brain’s housekeeper? Science. 2013;342:301.

    Google Scholar 

  2. Fregni F, Pascual-Leone A. Technology insight: noninvasive brain stimulation in neurology: perspectives on the therapeutic potential of rTMS and tDCS. Nat Clin Pract Neurol. 2007;3:383–93.

    Article  PubMed  Google Scholar 

  3. Lindenberger U, Wenger E, Lövden M. Towards a stronger science of human plasticity. Nat Rev Neurosci. 2017;18:261–2.

    Article  PubMed  Google Scholar 

  4. Cavanaugh MR, Huxlin KR. Visual discrimination training improves Humphrey perimetry in chronic cortically induced blindness. Neurology. 2017;88:1856–64.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Stern Y, Mackay-Brandt A, Lee S, et al. Effect of aerobic exercise on cognition in younger adults. A randomized clinical trial. Neurology. 2019:e905–16.

    Google Scholar 

  6. Ahlskog JE, Geda YE, Graff-Radford NR, Petersen RC. Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging. Mayo Clin Proc. 2011;86(9):876–84.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Ngandu T, Lehtisalo J, Solomon A, et al. A 2-year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385:2255–63.

    Article  PubMed  Google Scholar 

  8. Hughes LE, Rittman T, Robbins TW, Rower JB. Reorganization of cortical oscillatory dynamics underlying disinhibition in frontotemporal dementia. Brain. 2018;141:2486–99.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Thomson H. Wave therapy. Nature. 2018;555:20–2.

    Article  PubMed  Google Scholar 

  10. Malkani RG, Zee PC. BrainStimulation for improving sleep and memory. Sleep Med Clin. 2020;15(1):101–15.

    Article  PubMed  Google Scholar 

  11. Kaczmarczyk R, Tejera D, Simon BJ, Heneka MT. Microglia modulation through external vagus nerve stimulation in a murine model of Alzheimer’s disease. J Neurochem. 2018;146:76. https://doi.org/10.1111/jnc.14284.

    Article  Google Scholar 

  12. Alcami P, Pereda AE. Beyond plasticity: the dynamic impact of electrical synapses on neural circuits. Nat Rev Neurosci. 2019;20:253–71.

    Article  PubMed  Google Scholar 

  13. Connors BW. Synchrony and so much more diverse roles for electrical synapses in neural circuits. Dev Neurobiol. 2017;77:610–24.

    Article  PubMed  PubMed Central  Google Scholar 

  14. FIturria-Medina Y, Sotero RC, Toussaint PJ et al. Early role of vascular dysregulation on late onset Alzheimer’s disease based on multifactorial data driven analysis. Nature Communications 21 June 2016.

    Google Scholar 

  15. Osorio C, Kanukuntla T, Diaz E, Jafri N, Cummings M, Sfera A. The post amyloid era in Alzheimer’s disease: trust your gut feeling. Front Aging Neurosci. 2019; https://doi.org/10.3389/fnagi.2019.00143.

  16. Han W, Tellez LA, Perkins MH, et al. A neural circuit for gut-induced reward. Cell. 2018;175:665–78.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Marcantonio ER. Delirium in hospitalized older adults. N Engl J Med. 2017;377:1456–66.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Tang CY, Carpenter DM, Eaves EL, et al. Occupational solvent exposure and brain function: an f-MRI study. Environ Health Perspect. 2011;119:908–13.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Cahalan S. Brain on fire: my month of madness. New York: Simon and Schuster; 2013.

    Google Scholar 

  20. Novakovic-Agopian T, Chen A, Rome AJW, et al. Rehabilitation of executive functioning with training in attention regulation applied to individually defined goals: a pilot study bridging theory, assessment and treatment. J Head Trauma Rehabil. 2011;26:325–38.

    Article  PubMed  Google Scholar 

  21. Arnsten AFT, Goldman Rakic PS. Alpha 2 adrenergic mechanism in prefrontal cortex associated with cognitive decline in aged non human primates. Science. 1985;230:1273–6.

    Article  PubMed  Google Scholar 

  22. Arnsten AFT, Steere JC, Hunt RD. The contribution of alpha 2 noradrenergic mechanisms to prefrontal cortical function: potential significance for attention deficit hyperactivity disorder. Arch Gen Psychiatry. 1995;53:448–55.

    Article  Google Scholar 

  23. Sahakian BJ, Coull JJ, Hodges JR. Selective enhancement of executive function by idazoxan in a patient with dementia of the frontal lobe type. J Neurol Neurosurg Pyschiatry. 1994;57:120–1.

    Article  Google Scholar 

  24. Marin RS, Fogel BS, Hawkins J, Duffy J, Krupp B, Tolosa E, Zee DS. Apathy: a treatable syndrome. J Neuropsychiatry Clin Neurosci. 1995;7:23–30.

    Article  PubMed  Google Scholar 

  25. Wantanabe MD, Martin EM, DeLeon OA, Gaviria M, Pavel DG, Trepashko DW. Successful methylphenidate treatment of apathy after subcortical infarcts. J Neuropsychiatry Clin Neurosci. 1995;7:502–4.

    Article  Google Scholar 

  26. Barrett K. Treating organic abulia with bromocriptine and lisuride: Four studies. J Neurol Neurosurg Pyschiatry. 1991;54:7180721.

    Google Scholar 

  27. Holmes VF, Fernandes F, Levy JK. Psychostimulant therapy in AIDS related complex patients. J Clin Psychiatry. 1989;50:5–8.

    PubMed  Google Scholar 

  28. Parks RW, Crockett DJ, Manji HK, Ammann W. Assessment of bromocriptine intervention for the treatment of frontal lobe syndrome: a case study. J Neuropsychiatry Clin Neurosci. 1992;4:109–11.

    Article  PubMed  Google Scholar 

  29. Hollander E, Wong CM. Body dysmorphic disorder, pathological gambling, and sexual compulsions. J Clin Psychiatry. 1995;56:7–12.

    PubMed  Google Scholar 

  30. Olivier B, Mos J. Serenics and aggression. Stress Med. 1986;2:197–209.

    Article  Google Scholar 

  31. Bakchine S, Lacomblez L, Benoit N, Parisot D, Chain F, Lhermitte F. Manic-like state after bilateral orbitofrontal and right temporoparietal injury: efficacy of clonidine. Neurology. 1989;39:777–81.

    Article  PubMed  Google Scholar 

  32. Tariot PN, Schneider LS, Cummings J, Thomas RG, Raman R, Jakimovich LJ, Loy R, Bartocci B, Fleisher A, Ismail MS, Porsteinsson A, Weiner M, Jack CR Jr, Thal L, Aisen PS. Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease.; Alzheimer's disease cooperative study group. Arch Gen Psychiatry. 2011;68:853–61.

    Article  PubMed  PubMed Central  Google Scholar 

  33. O'Connor K, Todorov C, Robillard S, Borgeat F, Brault M. Cognitive-behaviour therapy and medication in the treatment of obsessive-compulsive disorder: a controlled study. Can J Psychiatr. 1999;44:64–71.

    Article  Google Scholar 

  34. Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, Yablon SA, Luther M, Hammond FM, Nordenbo A, Novak P, Mercer W, Maurer-Karattup P, Sherer M. Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med. 2012;366:819–26.

    Article  PubMed  Google Scholar 

  35. Willmott C, Ponsford J. Efficacy of methylphenidate in the rehabilitation of attention following traumatic brain injury: a randomised, crossover, double blind, placebo controlled inpatient trial. J Neurol Neurosurg Psychiatry. 2009;80:552–7.

    Article  PubMed  Google Scholar 

  36. Chollet F, Tardy J, Albucher JF, Thalamas C, Berard E, Lamy C, Bejot Y, Deltour S, Jaillard A, Niclot P, Guillon B, Moulin T, Marque P, Pariente J, Arnaud C, Loubinoux I. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol. 2011;10:123–30.

    Article  PubMed  Google Scholar 

  37. Rimer J, Dwan K, Lawlor DA, Greig CA, McMurdo M, Morley W, Mead GE. Exercise for depression. Cochrane Database Syst Rev. 2012;7:CD004366.

    Google Scholar 

  38. Lee JC, Blumberger DM, Fitzgerald P, Daskalakis Z. Levinson a The Role of Transcranial Magnetic Stimulation in Treatment-Resistant Depression: A Review. Curr Pharm Des. 2012;6. [Epub ahead of print]

    Google Scholar 

  39. Farahani A, Correll CU. Are antipsychotics or antidepressants needed for psychotic depression? A systematic review and meta-analysis of trials comparing antidepressant or antipsychotic monotherapy with combination treatment. J Clin Psychiatry. 2012;73(4):486–96.. Review

    Article  PubMed  PubMed Central  Google Scholar 

  40. Dougherty DD, Weiss AP, Cosgrove GR, Alpert NM, Cassem EH, Nierenberg AA, Price BH, Mayberg HS, Fischman AJ, Rauch SL. Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depression. J Neurosurg. 2003;99:1010–7.

    Article  PubMed  Google Scholar 

  41. Chamberlain SR, Del Campo N, Dowson J, Muller U, Clark L, et al. Atomoxetine improved response inhibition in adults with attention deficit hyperactivity disorder. Biol Pyschiatry. 2007;62:977–84.

    Article  Google Scholar 

  42. Panitch HS, Thisted RA, Smith RA, Wynn DR, Wymer JP, Achiron A, Vollmer TL, Mandler RN, Dietrich DW, Fletcher M, Pope LE, Berg JE, Miller A. Pseudobulbar affect in multiple sclerosis study group. Ann Neurol. 2006;59:780–7.

    Article  PubMed  Google Scholar 

  43. Miller A, Pratt H, Schiffer RB. Pseudobulbar affect: the spectrum of clinical presentations, etiologies and treatments. Expert Rev Neurother. 2011;11:1077–88.

    Article  PubMed  Google Scholar 

  44. Davidson RJ, Begley S. In their book the emotional life of your brain. New York: Hudson Street Press; 2012.

    Google Scholar 

  45. Fava GA, Tomba E. Increasing psychological Well-being and resilience by psychotherapeutic methods. J Pers. 2009;77:1903–34.

    Article  PubMed  Google Scholar 

  46. Hoelzel BK, Ott U, Gard T, Hempel H, Weygandt M, Morgen K, Vaitl D. Investigation of mindfulness meditation practitioners with voxel based morphometry. Soc Cogn Affect Neurosci. 2008;3:55–61.

    Article  Google Scholar 

  47. Cappa SF, Benke T, Clarke S, Rossi B, Stemmer B, van Heugten CM. EFNS guidelines on cognitive rehabilitation: report of an EFNS task force. Eur Neurol. 2005;12:665–80.

    Article  Google Scholar 

  48. Wolf SL, Winstein CJ, Miller JP, Taub E, Uswatte G, Morris D, Giuliani C, Light KE, Nichols-Larsen DS. Effect of constraint induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. JAMA. 2006;296:2095–104.

    Article  PubMed  Google Scholar 

  49. Wolf SL, Thompson PA, Winstein CJ, Miller JP, Blanton SR, Nichols-Larsen DS, Morris DM, Uswatte G, Taub E, Light KE, Swaki L. The EXCITE stroke trial: comparing early and delayed constraint induced movement therapy. Stroke. 2010;41:2309–15.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Han JW, Oh K, Yoo S, et al. Development of the ubiquitous spaced retrieval-based memory advancement and rehabilitation training program. Psychiatry Investig. 2014;11(1):52–8.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Haslam C, Moss Z, Hodder K. Are two methods better than one? Evaluating the effectiveness of combining errorless learning with vanishing cues. J Clin Exp Neuropsychol. 2010;32(9):973–85.

    Article  PubMed  Google Scholar 

  52. Stringer AY, Small SK. Ecologically-oriented neurorehabilitation of memory: robustness of outcome across diagnosis and severity. Brain Inj. 2011;25(2):169–78.

    Article  PubMed  Google Scholar 

  53. Klingberg T, et al. Training of working memory in children with ADHD. J Clin Exp Neuropsychol. 2002;24:781–91.

    Article  PubMed  Google Scholar 

  54. Klingberg T, et al. Computerized training of working memory in children with ADHD – a randomized controlled trial. J Am Acad Child Adolesc Psychiatry. 2005;44:177–86.

    Article  PubMed  Google Scholar 

  55. Sibley BA, Beilock SL. Exercise and working memory: an individual differences investigation. J Sport Exerc Psychol. 2007;29:783–91.

    Article  PubMed  Google Scholar 

  56. Zhu N, Jacobs DR, Schreiner PJ, Yaffe K, Bryan N, Launer LJ, Whitmer RA, Sidney S, Demerath E, Thomas W, Bouchard C, He K, Reis J, Sternfeld B. Cardiorespiratory fitness and cognitive function in middle age. CARDIA Study Neurol. 2014;82:1339–46.

    Article  Google Scholar 

  57. Smania N, Girardi F, Domenicali C, Lora E, Aglioti S. The rehabilitation of limb apraxia: a study in left-brain-damaged patients. Arch Phys Med Rehabil. 2000;81(4):379–88.

    Article  PubMed  Google Scholar 

  58. Bolognini N, Convento S, Banco E, Mattioli F, Tesio L, Vallar G. Improving ideomotor limb apraxia by electrical stimulation of the left parietal cortex. Brain. 2015;138:428–39.

    Article  PubMed  Google Scholar 

  59. Bianchi M, Cosseddu M, Cotelli M, Manenti R, Brambilla M, Rizzetti MC, Padovani A, Borroni B. Left parietal cortex transcranial direct current stimulation enhances gesture processing in corticobasal syndrome. Eur J Neurol. 2015;22:1317. https://doi.org/10.1111/ene.12748.

    Article  PubMed  Google Scholar 

  60. Taskapilioglu O, Karli N, Erer S, Zarifoglu M, Bakar M, Turan F. Primary gait ignition disorder: report of three cases. Neurol Sci. 2009;30:333–7.

    Article  PubMed  Google Scholar 

  61. Raymer AM, McHose B, Smith KG, Iman L, Ambrose A, Casselton C. Contrasting effects of errorless naming treatment and gestural facilitation for word retrieval in aphasia. Neuropsychol Rehabil. 2012;22(2):235–66.

    Article  PubMed  Google Scholar 

  62. Hanlon Brown RE, Brown JW, Gerstman LJ. Enhancement of naming in nonfluent aphasia through gesture. Brain Lang. 1990;38:298–314.

    Article  PubMed  Google Scholar 

  63. Hadar U, Wenkert-Olenik D, Krauss R, Soroker N. Gesture and processing of speech: neuropsychological evidence. Brain Lang. 1998;62:107–26.

    Article  PubMed  Google Scholar 

  64. Garrison KA, et al. The mirror neuron system: a neural substrate for methods in stroke rehabilitation. Neurorehabil Neural Repair. 2010;5:404–12.

    Article  Google Scholar 

  65. Bonilha L, Gleichgerrcht E, Nesland T, Rorden C, Fridriksson J. Success of Anomia Treatment in Aphasia Is Associated With Preserved Architecture of Global and Left Temporal Lobe Structural Networks. Neurorehabil Neural Repair. 2015;. pii: 1545968315593808

    Google Scholar 

  66. Altschuler EL, Multari A, Hirstein W, Ramachandran VS. Situational therapy for Wernicke's aphasia. Med Hypotheses. 2006;67(4):713–6.

    Article  PubMed  Google Scholar 

  67. Pulvermüller F, Roth VM. Communicative aphasia treatment as a further development of PACE therapy. Aphasiology. 1991;5:39–5.

    Article  Google Scholar 

  68. Corbetta M. Hemispatial neglect: clinic, pathogenesis, and treatment. Semin Neurol. 2014;34(5):514–23.

    Article  PubMed  Google Scholar 

  69. Matano A, Iosa M, Guariglia C, Pizzamiglio L, Paolucci S. Does outcome of neuropsychological treatment in patients with unilateral spatial neglect after stroke affect functional outcome? Eur J Phys Rehabil Med. 2015;51:737–43.

    PubMed  Google Scholar 

  70. Pandian JD, Arora R, Kaur P, et al. Mirror therapy in unilateral neglect after stroke (MUST trial): a randomized controlled trial. Neurology. 2014;83(11):1012–7.

    Article  PubMed  PubMed Central  Google Scholar 

  71. Arai T, Ohi H, Sasak H, Nobuto H, Tanaka K. Heimspatial sunglasses: effect on unilateral spatial neglect. Archiv Phys Med Rehabil. 1997;78:230–2.

    Article  Google Scholar 

  72. Gorgoraptis N, Mah YH, Machner B, et al. The effects of the dopamine agonist rotigotine on hemispatial neglect following stroke. Brain. 2012;135(Pt 8):2478–91.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Buxbaum LJ, Ferraro M, Whyte J, Gershkoff A, Coslett HB. Amantadine treatment of hemispatial neglect: a double-blind, placebo-controlled study. Am J Phys Med Rehabil. 2007;86(7):527–37.

    Article  PubMed  Google Scholar 

  74. Jacquin-Courtois S. Hemi-spatial neglect rehabilitation using non-invasive brain stimulation: Or how to modulate the disconnection syndrome? Ann Phys Rehabil Med. 2015. pii: S1877–0657(15)00471–6; https://doi.org/10.1016/j.rehab.2015.07.388.

    Article  PubMed  Google Scholar 

  75. Goedert KM, Zhang JY, Barrett AM. Prism adaptation and spatial neglect: the need for dose-finding studies. Front Hum Neurosci. 2015;9:243. https://doi.org/10.3389/fnhum.2015.00243.. eCollection 2015

    Article  PubMed  PubMed Central  Google Scholar 

  76. Guilbert A, Clément S, Moroni C. Hearing and music in unilateral spatial neglect neuro-rehabilitation. Front Psychol. 2014;5:1503. https://doi.org/10.3389/fpsyg.2014.01503.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Sanders TH, Weiss J, Hogewood L, et al. Cognition-enhancing Vagus nerve stimulation alters the epigenetic landscape. J Neurosci. 2019;39:3454–69.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Broncel A, Brocian R, Klos-Woitczak P, et al. Vagal nerve stimulation as a promising tool in the improvement of cognitive disorders. Brain Res Bull. 2020;155:37–47. https://doi.org/10.1016/j.brainresbull.2019.11.011.. Epub 2019

    Article  PubMed  Google Scholar 

  79. O’Reardon JP, Cristancho P, Peshek AD. Vagus nerve stimulation and treatment of depression: to the brainstem and beyond. Psychiatry. 2006;3(5):54–63.

    PubMed  PubMed Central  Google Scholar 

  80. Khurana D, et al. ImpACT 1 study group. Implant for augmentation of cerebral blood flow trial 1: a pilot study. Int J Stroke. 2009;4:480–5.

    Article  PubMed  Google Scholar 

  81. Ducharme S, Dougherty DD, Price BH. Neurosurgical treatmetns for psychiatric disorders. In: Miller C, editor. The human frontal lobes. London: Guilford Press; 2018.

    Google Scholar 

  82. Turan TN, Nizam A, Lynn MJ, et al. Relationship between risk factor control and vascular events in the SAMMPRIS trial. Neurology. 2017;88:379–85.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Ramachandran VS, Altschuler EL. The use of visual feedback, in particular mirror visual feedback, in restoring brain function. Brain. 2009;132:1693–710.

    Article  PubMed  Google Scholar 

  84. Tang Y-Y, Lu Q, Gen X, Stein EA, Yang Y, Posner MI. Short-term meditation induces white matter changes in the anterior cingulate. PNAS. 2010;107:15649–15,652.

    Article  PubMed  PubMed Central  Google Scholar 

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  1. Professor of Neurology, University of Central Florida, Chief of Neurology, Orlando VA Medical Center, Orlando, FL, USA

    Michael Hoffmann MD, PhD

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Hoffmann, M. (2020). Neuroplasticity and Other Treatment Options for Cognitive and Behavioral Neurological Syndromes. In: Clinical Mentation Evaluation. Springer, Cham. https://doi.org/10.1007/978-3-030-46324-3_13

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