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Integrative and Complementary Medicine in Psychiatry

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Tasman’s Psychiatry

Abstract

This chapter focuses on Integrative and Complementary Medicine (ICM) treatments with plausible mechanisms of action, supported by evidence of safety and efficacy in clinical trials. The key mental illness disorders covered included: mood, anxiety, stress-related, trauma, sleep, psychotic disorders, attention and hyperactivity disorder, and neurocognitive disorders. The major interventions covered include herbal and nutritional medicines, mind-body approaches (e.g., yoga, tai chi, qigong, breathwork), and acupuncture. All of the interventions discussed have relatively low side-effect profiles and high margins of safety, particularly when compared to prescription medications. There is reason to believe that certain herbal and nutraceutical agents exert significant neurobiological effects, in addition to supporting healthier functioning of the nervous system. Although some valuable ICM treatments have not been generally used by physicians in the United States or approved for specific indications by the FDA, based on the available evidence of safety and efficacy, they are well worth consideration by clinicians who want to explore more options for improving their patients’ health and wellbeing. Clinicians need to be mindful of differences in quality and standardization among supplements produced by different companies. Further, in clinical practice, it may require several trials to design effective integrative treatments. A well-informed clinician is best qualified to help patients and families develop a safe, evidence-based integrative treatment plan.

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References

  • Abbot, R., Chang, D. D., Eyre, H., & Lavretsky, H. (2017). Mind-body practices Tai Chi and Qigong in the treatment and prevention of psychiatric disorders. In P. L. Gerbarg, R. P. Brown, & P. R. Muskin (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 261–279). American Psychiatric Association Publishing.

    Google Scholar 

  • Abbott, R., & Lavretsky, H. (2013). Tai Chi and Qigong for the treatment and prevention of mental disorders. Psychiatric Clinics of North America, 36(1), 109–120.

    Article  PubMed  Google Scholar 

  • Afshar, H., Roohafza, H., et al. (2012). N-acetylcysteine add-on treatment in refractory obsessive-compulsive disorder: A randomized, double-blind, placebo-controlled trial. Journal of Clinical Psychopharmacology, 32(6), 797–803.

    Article  CAS  PubMed  Google Scholar 

  • Akhondzadeh, S., & Abbasi, S. H. (2006). Herbal medicine in the treatment of Alzheimer’s disease. American Journal of Alzheimer’s Disease and Other Dementias, 21, 113–118.

    Article  PubMed  Google Scholar 

  • Akhondzadeh, S., Naghavi, H. R., Vazirian, M., et al. (2001). Passionflower in the treatment of generalized anxiety: A pilot double-blind randomized controlled trial with oxazepam. Journal of Clinical Pharmacy and Therapeutics, 26, 363–367.

    Article  CAS  PubMed  Google Scholar 

  • Akhondzadeh, S., Noroozian, M., Mohammadi, M., et al. (2003). Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: A double blind, randomised, placebo-controlled trial. Journal of Neurology, Neurosurgery, and Psychiatry, 74(7), 863–866.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Akhondzadeh, S., Fallah-Pour, H., Afkham, K., et al. (2004a). Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial. BMC Complementary and Alternative Medicine, 4, 12.

    Article  PubMed  PubMed Central  Google Scholar 

  • Akhondzadeh, S., Mohammadi, M. R., & Khademi, M. (2004b). Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: A double blind and randomized trial. BMC Psychiatry, 4, 9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Akhondzadeh, S., Tahmacebi-Pour, N., Noorbala, A. A., et al. (2005). Crocus sativus L. in the treatment of mild to moderate depression: A double-blind, randomized and placebo-controlled trial. Phytotherapy Research, 19, 148–151.

    Article  PubMed  Google Scholar 

  • Akhondzadeh, B., Moshiri, E., et al. (2007). Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: A pilot double-blind randomized trial. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30(2), 439–442.

    Article  Google Scholar 

  • Akhondzadeh, S., Sabet, M. S., Harirchian, M. H., et al. (2010). Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: A 16-week, randomized and placebo-controlled trial. Journal of Clinical Pharmacology and Therapeutics, 35, 581–588.

    Article  CAS  Google Scholar 

  • Akhondzadeh, S., Brown, R. P., & Gerbarg, P. L. (2013). Nutrients for prevention and treatment of mental health disorders. Psychiatric Clinics of North America, 36(1), 25–36.

    Article  PubMed  Google Scholar 

  • Almeida, J. C., & Grimsley, E. W. (1996). Coma from the health food store: Interaction between kava and alprazolam. Annals of Internal Medicine, 125, 940–941.

    Article  CAS  PubMed  Google Scholar 

  • Amaducci, L. (1988). Phosphatidylserine in the treatment of Alzheimer’s disease: Results of a multicenter study. Psychopharmacology Bulletin, 24, 130–134.

    CAS  PubMed  Google Scholar 

  • American Psychiatric Association. (2015). Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Press.

    Google Scholar 

  • Amminger, G. P., Schafer, M. R., Papageorgiou, K., et al. (2010). Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: A randomized, placebo-controlled trial. Archives of General Psychiatry, 67(2), 146–154.

    Article  CAS  PubMed  Google Scholar 

  • Amminger, G. P., Nelson, B., Markulev, C., et al. (2020). The NEURAPRO biomarker analysis: Long-chain Omega-3 fatty acids improve 6-month and 12-month outcomes in youths at ultra-high risk for psychosis. Biological Psychiatry, 87(3), 243–252.

    Article  CAS  PubMed  Google Scholar 

  • Amsterdam, J. D., Li, Y., et al. (2009). A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. Journal of Clinical Psychopharmacology, 29(4), 378–382.

    Article  PubMed  PubMed Central  Google Scholar 

  • Antalis, C. J., Stevens, L. J., Campbell, M., et al. (2006). Omega-3 fatty acid status in attention-deficit/hyperactivity disorder. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 75, 299–308.

    Article  CAS  PubMed  Google Scholar 

  • Appel, K., Rose, T., Fiebich, B., et al. (2011). Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytotherapy Research, 25(6), 838–843.

    Article  CAS  PubMed  Google Scholar 

  • Arendt, J. (1997). Jet lag/night shift, blindness and melatonin. Transactions of the Medical Society of London, 114, 7–9.

    PubMed  Google Scholar 

  • Arnold, L. E., Amato, A., et al. (2007). Acetyl-l-carnitine (ALC) in attention-deficit/hyperactivity disorder: A multi-site, placebo-controlled pilot trial. Journal of Child and Adolescent Psychopharmacology, 17(6), 791–801.

    Article  PubMed  Google Scholar 

  • Arnold, L. E., Disilvestro, R. A., & Bozzolo, D. (2011). Zinc for attention-deficit/hyperactivity disorder: Placebo-controlled double-blind pilot trial alone and combined with amphetamine. Journal of Child and Adolescent Psychopharmacology, 1(1), 1–19.

    Article  Google Scholar 

  • Awad, R., Levac, D., et al. (2007). Effects of traditionally used anxiolytic botanicals on enzymes of the γ-aminobutyric acid (GABA) system. Canadian Journal of Physiology & Pharmacology, 85(9), 933–942.

    Article  CAS  Google Scholar 

  • Ballard, C. G., O’Brien, J. T., Reichelt, K., et al. (2002). Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: The results of a double-blind, placebo-controlled trial with Melissa. Journal of Clinical Psychiatry, 63(7), 553–558.

    Article  PubMed  Google Scholar 

  • Barberger-Gateau, P., Raffaitin, C., Letenneur, L., et al. (2007). Dietary patterns and risk of dementia: The Three-City cohort study. Neurology, 69(20), 1921–1930.

    Article  CAS  PubMed  Google Scholar 

  • Beauregard, M., & Levesque, J. (2006). Functional magnetic resonance imaging investigation of the effects of neurofeedback training on the neural bases of selective attention and response inhibition in children with attention-deficit/hyperactivity disorder. Applied Psychophysiology and Biofeedback, 31(1), 3–20.

    Article  PubMed  Google Scholar 

  • Bell, I. R., Morrow, F. D., Read, M., et al. (1992). Low thyroxine levels in female psychiatric inpatients with riboflavin deficiency: Implications for folate-dependent methylation. Acta Psychiatrica Scandinavica, 85, 360–363.

    Article  CAS  PubMed  Google Scholar 

  • Bellon, A. (2006). Searching for new options for treating insomnia: Are melatonin and ramelteon beneficial? Journal of Psychiatric Practice, 12, 229–243.

    Article  PubMed  Google Scholar 

  • Bender, K. J. (2000). Investigating inositol in psychiatry. Psychiatric Times, 41–46.

    Google Scholar 

  • Benjamin, J., Agam, G., Levine, J., et al. (1995a). Inositol treatment in psychiatry. Psychopharmacology Bulletin, 31, 167–175.

    CAS  PubMed  Google Scholar 

  • Benjamin, J., Levine, J., Fux, M., et al. (1995b). Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. American Journal of Psychiatry, 152, 1084–1086.

    Article  CAS  PubMed  Google Scholar 

  • Benke, D., Barberis, A., Kopp, S., et al. (2009). GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology, 56(1), 174–181.

    Article  CAS  PubMed  Google Scholar 

  • Benson, H., Malhotra, M. S., Goldman, R. F., et al. (1990). Three case reports of the metabolic and electroencephalographic changes during advanced Buddhist meditation techniques. Behavioral Medicine, 16, 90–95.

    Article  CAS  PubMed  Google Scholar 

  • Bent, S., Padula, A., Moore, D., et al. (2006). Valerian for sleep: A systematic review and meta-analysis. American Journal of Medicine, 119(12), 1005–1012.

    Article  PubMed  Google Scholar 

  • Benton, D., Haller, J., & Fordy, J. (1995). Vitamin supplementation for 1 year improves mood. Neuropsychobiology, 32, 98–105.

    Article  CAS  PubMed  Google Scholar 

  • Berger, G. E., Proffitt, T. M., McConchie, M., et al. (2007). Ethyl-eicosapentaenoic acid in first-episode psychosis: A randomized, placebo-controlled trial. Journal of Clinical Psychiatry, 68(12), 1867–1875.

    Article  CAS  PubMed  Google Scholar 

  • Berk, M., Copolov, D., Dean, O., et al. (2008). N-Acetylcysteine as a glutathione precursor for schizophrenia – A double-blind, randomized, placebo-controlled trial. Biological Psychiatry, 64(5), 361–368.

    Article  CAS  PubMed  Google Scholar 

  • Berk, M., Munib, A., Dean, O., et al. (2011). Qualitative methods in early-phase drug trials: Broadening the scope of data and methods from an RCT of N-acetylcysteine in schizophrenia. Journal of Clinical Psychiatry, 72(7), 909–913.

    Article  CAS  PubMed  Google Scholar 

  • Bersani, G., & Garavini, A. (2000). Melatonin add-on in manic patients with treatment resistant insomnia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 24, 185–191.

    Article  CAS  PubMed  Google Scholar 

  • Bhargav, H. (2020). Tele-yoga for stress management: Need of the hour during the COVID-19 pandemic and beyond? Asian Journal of Psychiatry, 54, 1–3.

    Google Scholar 

  • Bhargav, H., George, S., Varambally, S., & Gangadhar, B. N. (2021a). Yoga and psychiatric disorders: A review of biomarker evidence. International Review of Psychiatry, 33(1–2), 162–169.

    Article  PubMed  Google Scholar 

  • Bhargav, P. H., Reddy, P. V., Govindaraj, R., et al. (2021b). Impact of a course of add-on supervised yoga on cortical inhibition in major depressive disorder: A randomized controlled trial. The Canadian Journal of Psychiatry, 66(2), 179–181.

    Article  PubMed  Google Scholar 

  • Bhatia, T., Agarwal, A., Shah, G., et al. (2012). Adjunctive cognitive remediation for schizophrenia using yoga: An open, non-randomized trial. Acta Neuropsychiatrica, 24, 91–100.

    Article  PubMed  Google Scholar 

  • Biederman, J., & Faraone, S. V. (2005). Attention-deficit hyperactivity disorder. The Lancet, 366(9481), 237–248.

    Article  Google Scholar 

  • Bilici, M., Yildirim, F., Kandil, S., et al. (2004). Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 28, 181–190.

    Article  CAS  PubMed  Google Scholar 

  • Birch, E. E., Garfield, S., Hoffman, D. R., et al. (2000). A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Developmental Medicine and Child Neurology, 42, 174–181.

    Article  CAS  PubMed  Google Scholar 

  • Birdsall, T. C. (1998). 5-Hydroxytryptophan: A clinically effective serotonin precursor. Alternative Medicine Review, 3(4), 271–280.

    CAS  PubMed  Google Scholar 

  • Bloch, M. H., & Qawasmi, A. (2011). Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: Systematic review and meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 50(10), 991–1000.

    Article  PubMed  PubMed Central  Google Scholar 

  • Blumenthal, M. (2017). Issues in phytomedicine related to psychiatric practice. In P. L. Gerbarg, R. P. Brown, & P. R. Muskin (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 105–112). American Psychiatric Association Publishing.

    Google Scholar 

  • Bottiglieri, T. (2013). Folate, vitamin B12, and S-adenosylmethionine. Psychiatric Clinics of North America, 36(1), 1–14.

    Article  PubMed  Google Scholar 

  • Bottiglieri, T., Gerbarg, P. L., & Brown, R. P. (2017). S-Adenosylmethionine. In P. L. Gerbarg, R. P. Brown, & P. R. Muskin (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 41–52). American Psychiatric Association Publishing.

    Google Scholar 

  • Bourre, J. M. (2005). Dietary omega-3 fatty acids and psychiatry: Mood, behaviour, stress, depression, dementia and aging. Journal of Nutrition, Health and Aging, 9, 31–38.

    CAS  Google Scholar 

  • Bourre, J. M. (2006). Effects of nutrients (in food) on the structure and function of the nervous system: Update on dietary requirements for brain. Part 2. Macronutrients. Journal of Nutrition Health and Aging, 10, 386–399.

    CAS  Google Scholar 

  • Boutron, I., Altman, D. G., Moher, D., for the CONSORT NPT Group, et al. (2017). CONSORT statement for randomized trials of nonpharmacologic treatments: A 2017 update and a CONSORT extension for nonpharmacologic trial. Annals of Internal Medicine, 167, 40–47.

    Article  PubMed  Google Scholar 

  • Brown, R. P., & Garbarg, P. L. (2004). The Rhodiola revolution. Rodale Press.

    Google Scholar 

  • Brown, R. P., & Gerbarg, P. L. (2005). Sudarshan Kriya yoga breathing in the treatment of stress, anxiety, and depression: Part I–Neurophysiological model. Journal of Complementary and Alternative Medicine, 11, 189–201.

    Article  Google Scholar 

  • Brown, R. P., & Gerbarg, P. L. (2009). Yoga breathing, meditation, and longevity. Annals of the New York Academy of Sciences, 1172, 54–62.

    Article  PubMed  Google Scholar 

  • Brown, R. P., & Gerbarg, P. L. (2011). Complementary and integrative treatments in brain injury. In J. M. Silver, T. W. McAllister, & S. C. Yudofsky (Eds.), Textbook of traumatic brain injury (2nd ed., pp. 599–622). American Psychiatric Publishing.

    Google Scholar 

  • Brown, R. P., & Gerbarg, P. L. (2012a). Non-drug treatments for ADHD: New options for kids, adults, and clinicians. W.W. Norton.

    Google Scholar 

  • Brown, R. P., & Gerbarg, P. L. (2012b). The healing power of the breath: Simple techniques to reduce stress and anxiety, enhance concentration, and balance your emotions. Shambhala Publications.

    Google Scholar 

  • Brown, R. P., & Gerbarg, P. L. (2017). Breathing techniques in psychiatric treatment. In P. L. Gerbarg, R. P. Brown, & P. R. Muskin (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 241–250). American Psychiatric Association Publishing.

    Google Scholar 

  • Brown, R. P., Gerbarg, P. L., & Bottiglieri, T. (2000). S-adenosylmethionine (SAMe) in the clinical practice of psychiatry, neurology, and internal medicine. Clinical Practice of Alternative Medicine, 1(4), 230–241.

    Google Scholar 

  • Brown, R. P., Gerbarg, P. L., & Ramazanov, Z. (2002). A phythomedicinal review of Rhodiola rosea. HerbalGram, 56, 40–62.

    Google Scholar 

  • Brown, R. P., Gerbarg, P. L., & Muskin, P. R. (2009). How to use herbs, nutrients, and yoga in mental health care. W.W. Norton.

    Google Scholar 

  • Brown, R. P., Gerbarg, P. L., & Muench, F. (2013). Breathing practices for treatment of psychiatric and stress-related medical conditions. Psychiatric Clinics of North America, 36(1), 121–140.

    Article  PubMed  Google Scholar 

  • Burns, N. R., Bryan, J., & Nettelbeck, T. (2006). Ginkgo biloba: No robust effect on cognitive abilities or mood in healthy young or older adults. Human Psychopharmacology, 21, 27–37.

    Article  PubMed  Google Scholar 

  • Businaro, R., Vauzour, D., Sarris, J., et al. (2021). Therapeutic opportunities for food supplements in neurodegenerative diseases and depression. Frontiers in Nutrition: Section Nutrition and Brain Health. (accepted).

    Google Scholar 

  • Bussing, R., Zima, B. T., et al. (2002). Use of complementary and alternative medicine for symptoms of attention-deficit hyperactivity disorder. Psychiatric Services, 53(9), 1096–1102.

    Article  PubMed  Google Scholar 

  • Cabyoglu, M. T., Ergene, N., et al. (2006). The mechanism of acupuncture and clinical applications. International Journal of Neuroscience, 116(2), 115–125.

    Article  PubMed  Google Scholar 

  • Caffarra, C., & Santamaria, V. (1987). The effects of phosphatidylserine in patients with mild cognitive decline: An open trial. Clinical Trials Journal, 24, 109–111.

    Google Scholar 

  • Cakici, N., Van Beveren, N., Judge-Hundal, G., et al. (2019). An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: A meta-analysis. Psychological Medicine, 49(14), 2307–2319.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cardoso, B. R., Cominetti, C., & Cozzolino, S. M. F. (2013). Importance and management of micronutrient deficiencies in patients with Alzheimer disease. Clinical Interventions in Aging, 8, 531–542.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carter, J., Gerbarg, P. L., Brown, R. P., et al. (2013). Multi-component yoga breath program for Vietnam veteran post-traumatic stress disorder: Randomized controlled trial. Journal of Traumatic Stress Disorders & Treatment, 2(3), 1–10.

    Article  Google Scholar 

  • Chalon, S. (2006). Omega-3 fatty acids and monoamine neurotransmission. Prostaglandins, Leukottrienes, and Essential Fatty Acids, 75(4–5), 259–269.

    Article  CAS  Google Scholar 

  • Chan, E., Rappaport, L. A., et al. (2003). Complementary and alternative therapies in childhood attention and hyperactivity problems. Journal of Developmental and Behavioral Pediatrics, 24(1), 4–8.

    Article  PubMed  Google Scholar 

  • Chang, J. P. C., Su, K.-P., Mondelli, V., et al. (2018). Omega-3 polyunsaturated fatty acids in youths with attention deficit hyperactivity disorder: A systematic review and meta-analysis of clinical trials and biological studies. Neuropsychopharmacology, 43(3), 534–545.

    Article  CAS  PubMed  Google Scholar 

  • Chen, E. Y., & Hui, C. L. (2012). HT1001, a proprietary North American ginseng extract, improves working memory in schizophrenia: A double-blind, placebo-controlled study. Phytotherapy Research, 26(8), 1166–1172.

    Article  PubMed  Google Scholar 

  • Chen, K. W., Berger, C. C., Manheimer, E., et al. (2012). Meditative therapies for reducing anxiety: A systematic review and meta-analysis of randomized controlled trials. Depression and Anxiety, 29(7), 545–562.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chen, W. G., Schloesser, D., Arensdorf, A. M., et al. (2021). The emerging science of interoception: Sensing, integrating, interpreting, and regulating signals within the self. Trends in Neuroscience, 44(1), 3–16.

    Article  CAS  Google Scholar 

  • Chengappa, K. N. R., Brar, J. S., Gannon, J. M., et al. (2018). Adjunctive use of a standardized extract of Withania somnifera (Ashwagandha) to treat symptom exacerbation in schizophrenia: A randomized, double-blind, placebo-controlled study. Journal of Clinical Psychiatry, 79(5), 17m11826.

    PubMed  Google Scholar 

  • Clough, A. R., Bailie, R. S., & Currie, B. (2003). Liver function test abnormalities in users of aqueous kava extracts. Journal of Toxicology. Clinical Toxicology, 41, 821–829.

    Article  PubMed  Google Scholar 

  • Conquer, J. A., Tierney, M. C., Zecevic, J., et al. (2000). Fatty acid analysis of blood plasma of patients with Alzheimer’s disease, other types of dementia, and cognitive impairment. Lipids, 35, 1305–1312.

    Article  CAS  PubMed  Google Scholar 

  • ConsumerLab.com. (2013). Product review: St. John’s Wort supplements review. https://www.consumerlab.com/reviews/St_Johns_Wort/stjohnswort/. Accessed 13 Jan 2014.

  • Coppen, A., & Bailey, J. (2000). Enhancement of the antidepressant action of fluoxetine by folic acid: A randomised, placebo-controlled trial. Journal of Affective Disorders, 60, 121–130.

    Article  CAS  PubMed  Google Scholar 

  • Cott, J. M. (2002). Herb-drug interactions: Focus on pharmacokinetics. CNS Spectrums, 6, 827–832.

    Article  Google Scholar 

  • Coulter, D. (2007). Assessment of the risk of hepatotoxicity with kava products. WHO Appointed Committee. World Health Organization.

    Google Scholar 

  • Craig, A. D. (2008). Interoception and emotion. In M. Lewis, J. M. Haviland-Jones, & L. F. Barrett (Eds.), Handbook of emotions (3rd ed., pp. 272–288). Guilford Press.

    Google Scholar 

  • Crook, T., Petrie, W., Wells, C., et al. (1992). Effects of phosphatidylserine in Alzheimer’s disease. Psychopharmacology Bulletin, 28, 61–66.

    CAS  PubMed  Google Scholar 

  • Czyrak, A., Rogoz, Z., Skuza, G., et al. (1992). Antidepressant activity of S-adenosyl-l-methionine in mice and rats. Journal of Basic and Clinical Physiology and Pharmacology, 3, 1–17.

    Article  CAS  PubMed  Google Scholar 

  • Darbinyan, V. A., Aslanyan, G., Embroyan, E., et al. (2007). SHR-5 and the treatment of depression. Nordic Journal of Psychiatry, 61, 5.

    Google Scholar 

  • Davidson, R. J., Kabat-Zinn, J., Schumacher, J., et al. (2003). Alterations in brain and immune function produced by mindfulness meditation. Psychosomatic Medicine, 65(4), 564–570.

    Article  PubMed  Google Scholar 

  • Dean, O. M., Bush, A., et al. (2012). Translating the Rosetta Stone of N-acetylcysteine. Biological Psychiatry, 71(11), 935–936.

    Article  PubMed  Google Scholar 

  • Descilo, T., Vedamurthachar, A., Gerbarg, P. L., et al. (2010). Effects of a yoga-breath intervention alone and in combination with an exposure therapy for PTSD and depression in survivors of the 2004 Southeast Asia tsunami. Acta Psychiatrica Scandinavica, 121(4), 289–300.

    Article  CAS  PubMed  Google Scholar 

  • Di Rocco, A., Rogers, J. D., Brown, R., et al. (2000). S-Adenosyl-methionine improves depression in patients with Parkinson’s disease in an open-label clinical trial. Movement Disorders, 15(6), 1225–1229.

    Article  PubMed  Google Scholar 

  • Diamond, B. J., & Bailey, M. R. (2013). Ginkgo biloba indications, mechanisms, and safety. Psychiatric Clinics of North America, 36(1), 73–83.

    Article  PubMed  Google Scholar 

  • Dodd, S., Maes, M., Anderson, G., et al. (2013). Putative neuroprotective agents in neuropsychiatric disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 42, 135–145.

    Article  CAS  PubMed  Google Scholar 

  • Donath, F., Quispe, S., Diefenbach, K., et al. (2000). Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry, 33, 47–53.

    Article  CAS  PubMed  Google Scholar 

  • Dowling, G. A., Mastick, J., Colling, E., et al. (2005). Melatonin for sleep disturbances in Parkinson’s disease. Sleep Medicine, 6, 459–466.

    Article  PubMed  Google Scholar 

  • Dubichev, A. G., Kurkin, B. A., Zapesochnaya, G. G., et al. (1991). Study of Rhodiola rosea root chemical composition using HPLC. Chemico-Pharmaceutical Journal, 2, 188–193.

    Google Scholar 

  • Duraiswamy, G., Thirthalli, J., Nagendra, H. R., et al. (2007). Yoga therapy as an add-on treatment in the management of patients with schizophrenia: A randomized controlled trial. Acta Psychiatrica Scandinavica, 116, 226–232.

    Article  CAS  PubMed  Google Scholar 

  • Ernst, E. (2002). The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John’s wort, ginseng, Echinacea, saw palmetto, and kava. Annals of Internal Medicine, 136, 42–53.

    Article  PubMed  Google Scholar 

  • Errington-Evans, N. (2012). Acupuncture for anxiety. CNS Neuroscience and Therapeutics, 18(4), 277–284.

    Article  PubMed  Google Scholar 

  • Farah, A. (2009). The role of L-methylfolate in depressive disorders. CNS Spectrums, 14(1 Suppl 2), 2–7.

    Article  PubMed  Google Scholar 

  • Fava, M., Rosenbaum, J. F., Birnbaum, R., et al. (1992). The thyrotropin response to thyrotropin-releasing hormone as a predictor of response to treatment in depressed outpatients. Acta Psychiatrica Scandinavica, 86, 42–45.

    Article  CAS  PubMed  Google Scholar 

  • Fava, M., Borus, J. S., Alpert, J. E., et al. (1997). Folate, vitamin B12, and homocysteine in major depressive disorder. American Journal of Psychiatry, 154(3), 426–428.

    Article  CAS  PubMed  Google Scholar 

  • FDA. (2002). Kava-containing dietary supplements may be associated with severe liver injury. US Food and Drug Administration Center for Food Safety and Applied Nutrition. http://www.fda.gov/food/resourcesforyou/consumers/ucm085482.htm. Accessed 13 Jan 2014.

  • Fehmi, L. G., Edward, E. T., & Shor, S. B. (2017). Open focus training for stress, pain, and psychosomatic illness. In P. L. Gerbarg, R. P. Brown, & P. R. Muskin (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 293–304). American Psychiatric Association Publishing.

    Google Scholar 

  • Fernández-San-Martín, M. I., Masa-Font, R., Palacios-Soler, L., et al. (2010). Effectiveness of valerian on insomnia: A meta-analysis of randomized placebo-controlled trials. Sleep Medicine, 11(6), 505–511.

    Article  PubMed  Google Scholar 

  • Feuerstein, G. (1998). The yoga tradition: Its history, literature, philosophy and practice. Hohm Press.

    Google Scholar 

  • Firth, J., Teasdale, S. B., Allott, K., et al. (2019). The efficacy and safety of nutrient supplements in the treatment of mental illness: A meta-synthesis and appraisal of 33 meta-analyses of randomized controlled trials. World Psychiatry, 18(3), 308–324.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fonkoue, I. T., Hu, Y., Jones, T., et al. (2020). Eight weeks of device-guided slow breathing decreases sympathetic nervous reactivity to stress in posttraumatic stress disorder. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 319(4), R466–R475.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Freund-Levi, Y., Eriksdotter-Jonhagen, M., Cederholm, T., et al. (2006). Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: A randomized double-blind trial. Archives of Neurology, 63, 1402–1408.

    Article  PubMed  Google Scholar 

  • Fusar-Poli, P., & Berger, G. (2012). Eicosapentaenoic acid interventions in schizophrenia: Meta-analysis of randomized, placebo-controlled studies. Journal of Clinical Psychopharmacology, 32(2), 179–185.

    Article  CAS  PubMed  Google Scholar 

  • Fux, M., Levine, J., Aviv, A., et al. (1996). Inositol treatment of obsessive-compulsive disorder. American Journal of Psychiatry, 153(9), 1219–1221.

    Article  CAS  PubMed  Google Scholar 

  • Gannon, J. M., Brar, J., Rai, A., et al. (2019). Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial. Annals of Clinical Psychiatry, 31(2), 123–129.

    PubMed  Google Scholar 

  • Gelenberg, A. J. (2000). St. John’s wort update. Biological Therapies in Psychiatry, 23, 22–24.

    Google Scholar 

  • Gerbarg, P. L., & Brown, R. P. (2013). Phytomedicines for prevention and treatment of mental health disorders. Psychiatric Clinics of North America, 36(1), 37–48.

    Article  PubMed  Google Scholar 

  • Gerbarg, P. L., & Brown, R. P. (2016a). Pause menopause with Rhodiola rosea, a natural selective estrogen receptor modulator. Phytomedicine, 23(9), 763–769.

    Article  PubMed  Google Scholar 

  • Gerbarg, P. L., & Brown, R. P. (2016b). Neurobiology and neurophysiology of breath practices in psychiatric care. Psychiatric Times, 33(11), 22–25.

    Google Scholar 

  • Gerbarg, P. L., & Brown, R. P. (2021). Non-western interventions for stress reduction and resilience. British Journal of Psychiatric Advances, 27(3), 198–200.

    Google Scholar 

  • Gerbarg, P. L., Wallace, G., & Brown, R. P. (2011). Mass disasters and mind-body solutions: Evidence and field insights. International Journal of Yoga Therapy, 21, 97–107.

    Article  Google Scholar 

  • Gerbarg, P. L., Brown, R. P., & Muskin, P. R. (2017a). Complementary and integrative medicine, DSM-5, and clinical decision making. In P. L. Gerbarg, R. P. Brown, & P. R. Muskin (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 9–20). American Psychiatric Association Publishing.

    Google Scholar 

  • Gerbarg, P. L., Muskin, P. R., & Brown, R. P. (Eds.). (2017b). Complementary and integrative treatments in psychiatric practice. American Psychiatric Association Publishing.

    Google Scholar 

  • Gerbarg, P. L. & Brown, R. P. (2017c). Integrating Rhodiola rosea into Clinical Practice. In P. L. Gerbarg, R. P. Brown, & P. R. Muskin (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 135–141). American Psychiatric Association Publishing.

    Google Scholar 

  • Gerbarg, P. L., Brown, R. P., Streeter, C. C., et al. (2019). Breath practices for survivor and caregiver stress, depression, and post-traumatic stress disorder: Connection, co-regulation, compassion. Integrative and Complementary Medicine OBM, 4(3), 1–24.

    Article  Google Scholar 

  • Gerbarg, P. L., Brown, R. P., Mansur, S., & Steidle, K. (2021). Survivors of mass disasters: Breath-based mind-body interventions and global platforms. In S. Okpaku (Ed.), Innovations in global mental health (pp. 1557–1579). Switzerland AG, Springer Nature.

    Google Scholar 

  • Gooneratne, N. S. (2008). Complementary and alternative medicine for sleep disturbances in older adults. Clinics in Geriatric Medicine, 24(1), 121–138.

    Article  PubMed  PubMed Central  Google Scholar 

  • Govindaraj, R., Varambally, S., Rao, N. P., et al. (2020). Does Yoga have a role in schizophrenia management? Current Psychiatry Reports, 22(12), 78.

    Article  PubMed  Google Scholar 

  • Granath, J., Ingvarsson, S., von Thiele, U., et al. (2006). Stress management: A randomized study of cognitive behavioural therapy and yoga. Cognitive Behaviour Therapy, 35, 3–10.

    Article  PubMed  Google Scholar 

  • Grant, J. E., Odlaug, B. L., et al. (2009). N-Acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: A double-blind, placebo-controlled study. Archives of General Psychiatry, 66(7), 756–763.

    Article  CAS  PubMed  Google Scholar 

  • Grima, N. A., Pase, M. P., et al. (2012). The effects of multivitamins on cognitive performance: A systematic review and meta-analysis. Journal of Alzheimer’s Disease, 29(3), 561–569.

    Article  CAS  PubMed  Google Scholar 

  • Guu, T. W., Mischoulon, D., Sarris, J., et al. (2020). A multi-national, multi-disciplinary Delphi consensus study on using omega-3 polyunsaturated fatty acids (n-3 PUFAs) for the treatment of major depressive disorder. Journal of Affective Disorders, 265, 233–238.

    Article  PubMed  Google Scholar 

  • Haffner, J., Roos, J., Goldstein, N., et al. (2006). The effectiveness of body oriented methods of therapy in the treatment of attention-deficit hyperactivity disorder (ADHD): Results of a controlled pilot study. Zeitschrift für Kinder-und Jugendpsychiatrie und Psychotherapie, 34, 37–47. (in German).

    Article  PubMed  Google Scholar 

  • Hebert, R., Lehmann, D., Tan, G., et al. (2005). Enhanced EEG alpha time domain phase synchrony during transcendental meditation: Implications for cortical integration theory. Signal Processing, 85(11), 2213–2232.

    Article  Google Scholar 

  • Helgason, C., & Sarris, J. (2013). Mind-body medicine for schizophrenia and psychotic disorders. Clinical Schizophrenia and Related Psychoses, 7(3), 138–148.

    Article  PubMed  Google Scholar 

  • Heresco-Levy, U., Javitt, D., Ermilov, M., et al. (1999). Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Archives of General Psychiatry, 56, 29–36.

    Article  CAS  PubMed  Google Scholar 

  • Herrera-Arellano, A., Jiménez-Ferrer, E., et al. (2007). Efficacy and tolerability of a standardized herbal product from Galphimia glauca on generalized anxiety disorder. A randomized, double-blind clinical trial controlled with lorazepam. Planta Medica, 73(8), 713–717.

    Article  CAS  PubMed  Google Scholar 

  • Herrera-Arellano, A., Jiménez-Ferrer, J. E., et al. (2012). Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Medica, 78(14), 1529–1535.

    Article  CAS  PubMed  Google Scholar 

  • Herrero, J. L., Khuvis, S., & Mehta, A. D. (2017). Breathing above the brainstem: Volitional control and attentional modulation in humans. Journal of Neurophysiology, 119(1), 145–159.

    Article  PubMed  PubMed Central  Google Scholar 

  • Herrschaft, H., Nacu, A., & Likhachev, S. (2012). Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: A randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg. Journal of Psychiatric Research, 46(6), 716–723.

    Article  PubMed  Google Scholar 

  • Hibbeln, J. R. (1998). Fish consumption and major depression. The Lancet, 351(9110), 1213.

    Article  CAS  Google Scholar 

  • Hirayama, S., Hamazaki, T., et al. (2004). Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder – A placebo-controlled double-blind study. European Journal of Clinical Nutrition, 58(3), 467–473.

    Article  CAS  PubMed  Google Scholar 

  • Hirayama, S., Terasawa, K., Rabeler, R., et al. (2013). The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: A randomised, double-blind, placebo-controlled clinical trial. Journal of Human Nutrition and Dietetics Suppl. 2:284–291.

    Google Scholar 

  • Holtmann, M., & Stadler, C. (2006). Electroencephalographic biofeedback for the treatment of attention-deficit hyperactivity disorder in childhood and adolescence. Expert Review of Neurotherapeutics, 6, 533–540.

    Article  PubMed  Google Scholar 

  • Hopper, J. W., Frewen, P. A., van der Kolk, B. A., et al. (2007). Neural correlates of reexperiencing, avoidance, and dissociation in PTSD: Symptom dimensions and emotion dysregulation in responses to script-driven trauma imagery. Journal of Traumatic Stress, 20(5), 713–725.

    Article  PubMed  Google Scholar 

  • Hosseinzadeh, H., & Noraei, N. B. (2009). Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phytotherapy Research, 23(6), 768–774.

    Article  CAS  PubMed  Google Scholar 

  • Hourani, L. L., Davila, M. I., Morgan, J., et al. (2019). Mental health, stress, and resilience correlates of heart rate variability among military reservists, guardsmen, and first responders. Physiology and Behavior, 1(214), 112734.

    Google Scholar 

  • Howes, M. J., & Perry, E. (2011). The role of phytochemicals in the treatment and prevention of dementia. Drugs and Aging, 28(6), 439–468.

    Article  CAS  PubMed  Google Scholar 

  • Hsu, S.-M., Tseng, C.-H., Hsieh, C.-H., et al. (2020). Slow-paced inspiration regularizes alpha phase dynamics in the human brain. Journal of Neurophysiology, 123(1), 289–299.

    Article  PubMed  Google Scholar 

  • Hypericum Depression Trial Study Group. (2002). Effect of Hypericum perforatum (St. John’s wort) in major depressive disorder: A randomized controlled trial. JAMA, 287(14), 1807–1814.

    Article  Google Scholar 

  • Iwasaki, K., Satoh-Nakagawa, T., & Maruyama, M. (2005). A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. The Journal of Clinical Psychiatry, 66(2), 248–252.

    Article  PubMed  Google Scholar 

  • Izzo, A. A. (2004). Drug interactions with St. John’s wort (Hypericum perforatum): A review of the clinical evidence. International Journal of Clinical Pharmacology and Therapeutics, 42(3), 139–148.

    Article  CAS  PubMed  Google Scholar 

  • Jacobs, B. P., Bent, S., Tice, J. A., et al. (2005). An Internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. Medicine (Baltimore), 84, 197–207.

    Article  PubMed  Google Scholar 

  • Jayaram, N., Varambally, S., Behere, R. V., et al. (2013). Effect of yoga therapy on plasma oxytocin and facial emotion recognition deficits in patients of schizophrenia. Indian Journal of Psychiatry, 55(Suppl 3), S409–S413.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jensen, P. S., & Kenny, D. T. (2004). The effects of yoga on the attention and behavior of boys with attention-deficit/hyperactivity disorder (ADHD). Journal of Attention Disorders, 7, 205–216.

    Article  PubMed  Google Scholar 

  • Jensen, C. L., Chen, H., Fraley, J. K., et al. (1996). Biochemical effects of dietary linoleic/alpha-linolenic acid ratio in term infants. Lipids, 31, 107–113.

    Article  CAS  PubMed  Google Scholar 

  • Jiménez-Ferrer, E., Herrera-Ruiz, M., et al. (2011). Interaction of the natural anxiolytic galphimine-B with serotonergic drugs on dorsal hippocampus in rats. Journal of Ethnopharmacology, 137(1), 724–729.

    Article  PubMed  Google Scholar 

  • Kabat-Zinn, J., Massion, A. O., Kristeller, J., et al. (1992). Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders. American Journal of Psychiatry, 149(7), 936–943.

    Article  CAS  PubMed  Google Scholar 

  • Kalyani, B. G., Venkatasubramanian, G., Arasappa, R., et al. (2011). Neurohemodynamic correlates of ‘OM’ chanting: A pilot functional magnetic resonance imaging study. International Journal of Yoga, 4(1), 3–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Katsumoto, E., Ishida, T., Kinoshita, K., et al. (2021). Yokukansankachimpihange is useful to treat behavioral/psychological symptoms of dementia. Frontiers in Nutrition, 7, 529390.

    Article  PubMed  PubMed Central  Google Scholar 

  • Katzman, M. A., Vermani, M., Gerbarg, P. L., et al. (2012). A multicomponent yoga-based, breath intervention program as an adjunctive treatment in patients suffering from Generalized Anxiety Disorder (GAD) with or without comorbidities. International Journal of Yoga, 5(1), 57–65.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kayumov, L., Brown, G., Jindal, R., et al. (2001). A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome. Psychosomatic Medicine, 63, 40–48.

    Article  CAS  PubMed  Google Scholar 

  • Keefe, J. R., Mao, J. J., Soeller, I., et al. (2016). Short-term open-label chamomile (Matricaria chamomilla L) therapy of moderate to severe generalized anxiety disorder. Phytomedicine, 23, 1699–1705.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kennedy, D. O., & Scholey, A. B. (2006). The psychopharmacology of European herbs with cognition-enhancing properties. Current Pharmacuetical Design, 12(35), 4613–4623.

    Article  CAS  Google Scholar 

  • Kennedy, D. O., Wake, G., Savelev, S., et al. (2003). Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology, 28, 1871–1881.

    Article  CAS  PubMed  Google Scholar 

  • Kennedy, D. O., Little, W., & Scholey, A. B. (2004). Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (lemon balm). Psychosomatic Medicine, 66, 607–613.

    Article  PubMed  Google Scholar 

  • Kennedy, D. O., Pace, S., Haskell, C., et al. (2006). Effects of cholinesterase inhibiting sage (Salvia officinalis) in mood, anxiety and performance on a psychological stressor battery. Neuropsychopharmacology, 31(4), 845–852.

    Article  CAS  PubMed  Google Scholar 

  • Kennedy, D. O., Dodd, F. L., Robertson, B. C., et al. (2011). Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults. Journal of Psychopharmacology, 25(8), 1088–1100.

    Article  CAS  PubMed  Google Scholar 

  • Kenny, E., Muskin, P. R., Brown, R., et al. (2001). What the general psychiatrist should know about herbal medicine. Current Psychiatry Reports, 3, 226–234.

    Article  CAS  PubMed  Google Scholar 

  • Kidd, P. M. (2000). Attention deficit/hyperactivity disorder (ADHD) in children: Rationale for its integrative management. Alternative Medicine Review, 5, 402–428.

    CAS  PubMed  Google Scholar 

  • Kim, H. J., Kim, P., & Shin, C. Y. (2013). A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system. Journal of Ginseng Research, 37(1), 8–29.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Knüppel, L., & Linde, K. (2004). Adverse effects of St. John’s wort: A systematic review. Journal of Clinical Psychiatry, 65, 1470–1479.

    Article  PubMed  Google Scholar 

  • Ko, R. J. (1998). Adulterants in Asian patent medicines. New England Journal of Medicine, 339, 847.

    Article  CAS  PubMed  Google Scholar 

  • Konofal, E., Lecendreux, M., et al. (2008). Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatric Neurology, 38(1), 20–26.

    Article  PubMed  Google Scholar 

  • Kraft, M., Spahn, T. W., Menzel, J., et al. (2001). Fulminant liver failure after administration of the herbal antidepressant kava-kava. Deutsche Medizinische Wochenschrift, 126, 970–972. (in German).

    Article  CAS  PubMed  Google Scholar 

  • Kris-Etherton, P. M., Harris, W. S., Appel, L. J., & for the Nutrition Committee. (2002). Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation, 106, 2747–2757.

    Article  PubMed  Google Scholar 

  • Kwon, C.-Y., & Lee, B. (2021). Herbal medicine for behavioral and psychological symptoms of dementia: A systematic review and meta-analysis. Frontiers in Pharmacology, 12, 713287.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kyle, D. J., Schaefer, E., & Patton, G. (1998). Low serum docosahexanoic acid is a significant risk factor for Alzheimer’s dementia. Presented at the 3rd ISSFAL Congress, 1–5 June 1998, Lyon.

    Google Scholar 

  • Lake, J., Helgason, C., & Sarris, J. (2012). Integrative mental health (IMH): Paradigm, research, and clinical practice. Explore (New York, N.Y.), 8(1), 50–57.

    Article  PubMed  Google Scholar 

  • LaPorte, E., Sarris, J., et al. (2011). Neurocognitive effects of kava (Piper methysticum): A systematic review. Human Psychopharmacology, 26(2), 102–111.

    Article  CAS  PubMed  Google Scholar 

  • Larsen, S. (2006). The healing power of neurofeedback. The Healing Press.

    Google Scholar 

  • Lautenschlager, N. T., Ihl, R., et al. (2012). Ginkgo biloba extract EGb 761® in the context of current developments in the diagnosis and treatment of age-related cognitive decline and Alzheimer’s disease: A research perspective. International Psychogeriatrics, 24(Suppl 1), S46–S50.

    Google Scholar 

  • Lavretsky, H., & Feldman, J. L. (2021). Precision medicine for breath-focused mind-body therapies for stress and anxiety: Are we ready yet? Global Advances in Health and Medicine, 10, 1–4.

    Article  Google Scholar 

  • Lazar, S. W., Kerr, C. E., Wasserman, R. H., et al. (2005). Meditation experience is associated with increased cortical thickness. Neuroreport, 16, 1893–1897.

    Article  PubMed  PubMed Central  Google Scholar 

  • Le Bars, P. L., Velasco, F. M., Ferguson, J. M., et al. (2002). Influence of the severity of cognitive impairment on the effect of the Gnkgo biloba extract EGb 761 in Alzheimer’s disease. Neuropsychobiology, 45, 19–26.

    Article  PubMed  Google Scholar 

  • Lee, M. S., Kim, M. K., & Lee, Y. H. (2005a). Effects of Qi-therapy (external Qigong) on cardiac autonomic tone: A randomized placebo-controlled study. International Journal of Neuroscience, 115(9), 1345–1350.

    Article  PubMed  Google Scholar 

  • Lee, M. S., Rim, Y. H., Jeong, D. M., et al. (2005b). Nonlinear analysis of heart rate variability during Qi therapy (external Qigong). American Journal of Chinese Medicine, 33(4), 579–588.

    Article  PubMed  Google Scholar 

  • Lehmann, D., Faber, P. L., Achermann, P., et al. (2001). Brain sources of EEG gamma frequency during volitionally meditation-induced, altered states of consciousness, and experience of the self. Psychiatry Research, 108, 111–121.

    Article  CAS  PubMed  Google Scholar 

  • Lehrer, P., Karavidas, M. K., Lu, S. E., et al. (2010). Voluntarily produced increases in heart rate variability modulate autonomic effects of endotoxin induced systemic inflammation: An exploratory study. Applied Psychophysiology Biofeedback, 35(4), 303–315.

    Article  PubMed  Google Scholar 

  • Lerner, V., Kanevsky, M., Dwolatzky, T., et al. (2006). Vitamin B12 and folate serum levels in newly admitted psychiatric patients. Clinical Nutrition, 25, 60–67.

    Article  CAS  PubMed  Google Scholar 

  • Li, J. Y., Zhang, Y. F., Smith, G. S., et al. (2011a). Quality of reporting of randomized clinical trials in tai chi interventions – A systematic review. Evidence-based Complementary and Alternative Medicine, 2011, 383245.

    Article  PubMed  PubMed Central  Google Scholar 

  • Li, J. J., Li, Z. W., Wang, S. Z., et al. (2011b). Ningdong granule: A complementary and alternative therapy in the treatment of attentiondeficit/hyperactivity disorder. Psychopharmacology, 216(4), 501–509.

    Article  CAS  PubMed  Google Scholar 

  • Linde, K., Ramirez, G., Mulrow, D. F., et al. (1996). St. John’s wort for depression – An overview and meta-analysis of randomized clinical trials. BMJ, 313(7052), 253–258.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Linde, K., Berner, M., et al. (2008). St John’s wort for major depression. Cochrane Database of Systematic Reviews, (4), CD000448.

    Google Scholar 

  • Lutz, A., Greischar, L. L., Rawlings, N. B., et al. (2004). Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. Proceedings of the National Academy of Sciences of The United States of America, 101, 16369–16373.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lyon, M. R., Cline, J. C., Totosy de Zepetnek, J., et al. (2001). Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: A pilot study. Journal of Psychiatry and Neuroscience, 26, 221–228.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Maciocia, G. (1994). The practice of Chinese medicine: The treatment of diseases with acupuncture and Chinese herbs. Churchill Livingstone.

    Google Scholar 

  • Manjunath, N. K., & Telles, S. (2005). Influence of Yoga and Ayurveda on self rated sleep in a geriatric population. Indian Journal of Medical Research, 121, 683–690.

    CAS  PubMed  Google Scholar 

  • Mao, J. J., Xie, S. X., Keefe, J. R., et al. (2016). Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial. Phytomedicine, 23(14), 1735–1742.

    Google Scholar 

  • Marchand, W. R. (2013). Mindfulness meditation practices as adjunctive treatments for psychiatric disorders. Psychiatric Clinics of North America, 36(1), 141–152.

    Article  PubMed  Google Scholar 

  • Marx, W., Lane, M., Rocks, T., et al. (2019). Effect of saffron supplementation on symptoms of depression and anxiety: A systematic review and meta-analysis. Nutrition Review, 28, nuz023.

    Google Scholar 

  • Mason, H., Gerbarg, P. L., & Brown, R. P. (2021). Psychophysiology: Healing effects of voluntarily regulated breathing practices. In S. Telles & R. K. Gupt (Eds.), Handbook of research on evidence-based perspectives on the psychophysiology of yoga and its applications (pp. 24–48). IGI Global.

    Chapter  Google Scholar 

  • Massoumi, L. (2017). The growth of complementary and integrative medicine. In P. L. In Gerbarg, R. P. Brown, & P. R. Muskin (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 1–3). American Psychiatric Association Publishing.

    Google Scholar 

  • Mathews, J. D., Riley, M. D., Fejo, L., et al. (1988). Effects of the heavy usage of kava on physical health: Summary of a pilot survey in an aboriginal community. Medical Journal of Australia, 148, 548–555.

    Article  CAS  PubMed  Google Scholar 

  • Mathews, J. M., Etheridge, A. S., Black, S. R., et al. (2002). Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metabolism and Disposition, 30, 1153–1157.

    Article  CAS  PubMed  Google Scholar 

  • Mendelson, S. D. (2020). Herbal treatment of major depression. CRC Press Taylor & Francis Group.

    Google Scholar 

  • Meng, X.-Z., Wu, F., Wei, P.-K., et al. (2012). A Chinese herbal formula to improve general psychological status in posttraumatic stress disorder: A randomized placebo-controlled trial on Sichuan earthquake survivors. Evidence-based Complementary and Alternative Medicine, 2012, 691258.

    Article  PubMed  Google Scholar 

  • Meseguer, E., Taboada, R., Sanchez, V., et al. (2002). Life-threatening parkinsonism induced by kava-kava. Movement Disorders, 17(1), 195–196.

    Article  PubMed  Google Scholar 

  • Miller, L. G. (1998). Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions. Archives of Internal Medicine, 158, 2200–2211.

    Article  CAS  PubMed  Google Scholar 

  • Miller, J. J., Fletcher, K., & Kabat-Zinn, J. (1995). Three-year follow-up and clinical implications of a mindfulness-based stress reduction intervention in the treatment of anxiety disorders. General Hospital Psychiatry, 17, 192–200.

    Article  CAS  PubMed  Google Scholar 

  • Mischoulon, D., Price, L. H., Carpenter, L. L., et al. (2014). A double-blind, randomized, placebo-controlled clinical trial of S-adenosyl-l-methionine (SAMe) versus escitalopram in major depressive disorder. Journal of Clinical Psychiatry, 75(4), 370–376.

    Article  CAS  PubMed  Google Scholar 

  • Miyake, Y., Sasaki, S., Tanaka, K., et al. (2006). Dietary folate and vitamins B12, B6, and B2 intake and the risk of postpartum depression in Japan: The Osaka Maternal and Child Health Study. Journal of Affective Disorders, 96, 133–138.

    Article  CAS  PubMed  Google Scholar 

  • Miyaoka, T., Furuya, M., Horiguchi, J., et al. (2015a). Efficacy and safety of yokukansan in treatment-resistant schizophrenia: A randomized, double-blind, placebo-controlled trial (a Positive and Negative Syndrome Scale, five-factor analysis). Psychopharmacology, 232(1), 155–164.

    Article  CAS  PubMed  Google Scholar 

  • Miyaoka, T., Furuya, M., Horiguchi, J., et al. (2015b). Efficacy and safety of yokukansan in treatment-resistant schizophrenia: A randomized, multicenter, double-blind, placebo-controlled trial. Evidence-based Complementary and Alternative Medicine, 2015, 1–11.

    Article  Google Scholar 

  • Miyasaka, L. S., Atallah, A. N., et al. (2007). Passiflora for anxiety disorder. Cochrane Database of Systematic Reviews, (1), CD004518.

    Google Scholar 

  • Modabbernia, A. (2017). Melatonin and melatonin analogues for psychiatric disorders. In P. L. Gerbarg, R. P. Brown, & P. R. Muskin (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 211–220). American Psychiatric Association Publishing.

    Google Scholar 

  • Modabbernia, A., & Akhondzadeh, S. (2013). Saffron, passionflower, valerian, and sage for mental health. Psychiatric Clinics of North America, 36(1), 85–92.

    Article  PubMed  Google Scholar 

  • Moriyama, T. S., Polanczyk, G., et al. (2012). Evidence-based information on the clinical use of neurofeedback for ADHD. Neurotherapeutics, 9(3), 588–598.

    Article  PubMed  PubMed Central  Google Scholar 

  • Morris, M. C., Evans, D. A., Bienias, J. L., et al. (2003). Dietary fats and the risk of incident Alzheimer disease. Archives of Neurology, 60, 194–200.

    Article  PubMed  Google Scholar 

  • Moshiri, E., Basti, A. A., et al. (2006). Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: A double-blind, randomized and placebo-controlled trial. Phytomedicine, 13(9–10), 607–611.

    Article  PubMed  Google Scholar 

  • Movafegh, A., Alizadeh, R., et al. (2008). Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: A double-blind, placebo-controlled study. Anesthesia and Analgesia, 106(6), 1728–1732.

    Article  PubMed  Google Scholar 

  • Muench, F., & Kumar, D. S. (2017). Using technology-based mind-body tools in clinical practice. In P. L. Gerbarg, R. P. Brown, & P. R. Muskin (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 353–366). American Psychiatric Association Publishing.

    Google Scholar 

  • Mukai, T., Kishi, T., Mats, Y., et al. (2014). A meta-analysis of inositol for depression and anxiety disorders. Human Psychopharmacology Clinical and Experimental, 29, 55–63.

    Article  CAS  PubMed  Google Scholar 

  • Muller, S. F., & Klement, S. (2006). A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children. Phytomedicine, 13, 383–387.

    Article  CAS  PubMed  Google Scholar 

  • Muller, W. E., Singer, A., Wonnemann, M., et al. (1998). Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract. Pharmacopsychiatry, 31(Suppl 1), 16–21.

    Article  CAS  PubMed  Google Scholar 

  • Murdoch, I., Perry, E. K., Court, J. A., et al. (1998). Cortical cholinergic dysfunction after human head injury. Journal of Neurotrauma, 15, 295–305.

    Article  CAS  PubMed  Google Scholar 

  • Muskin, P. R. (Ed.). (2000). Complementary and alternative medicine and psychiatry (Review of psychiatry) (Vol. 19). American Psychiatric Press.

    Google Scholar 

  • Negi, K. S., Singh, Y. D., Kushwaha, K. P., et al. (2000). Clinical evaluation of memory enhancing properties of Memory Plus in children with attention deficit hyperactivity disorder (Abstract). Indian Journal of Psychiatry, 42(Suppl 2), 4.

    Google Scholar 

  • Ng, B. Y. (1999). Qigong-induced mental disorders: A review. Australian and New Zealand Journal of Psychiatry, 33, 197–206.

    Article  CAS  PubMed  Google Scholar 

  • Ng, Q. X., Venkatanarayanan, N., & Ho, C. Y. X. (2017). Clinical use of Hypericum perforatum (St John’s wort) in depression: A meta-analysis. Journal of Affective Disorders, 210, 211–221.

    Article  CAS  PubMed  Google Scholar 

  • Nidecker, A. (1997). Probing genes, drugs, and fatty acids in dementia. Clinical Psychiatry News, December, 4.

    Google Scholar 

  • Nierenberg, A. A., Burt, T., Matthews, J., et al. (1999). Mania associated with St. John’s wort. Biological Psychiatry, 46, 1707–1708.

    Article  CAS  PubMed  Google Scholar 

  • Nierenberg, A. A., Ostacher, M. J., Calabrese, J. R., et al. (2006). Treatment-resistant bipolar depression: A STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone. American Journal of Psychiatry, 163, 210–216.

    Article  PubMed  Google Scholar 

  • Noorbala, A. A., Akhondzadeh, S., Tahmacebi-Pour, N., et al. (2005). Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: A double-blind, randomized pilot trial. Ethnopharmacology, 97(2), 281–284.

    Article  CAS  PubMed  Google Scholar 

  • Numata, T., Gunfan, S., Takayama, S., et al. (2014). Treatment of posttraumatic stress disorder using the traditional Japanese herbal medicine saikokeishikankyoto: A randomized observer-blinded controlled trial in survivors of the great East Japan earthquake and tsunami. Evidence-Based Complementary and Alternative Medicine, 2014, 683293.

    Article  PubMed  PubMed Central  Google Scholar 

  • Nyer, M., Gerbarg, P. L., Liveri, M. M., Johnston, J., Scott, T. M., Nauphal, M., Owen, L., Nielsen, G. H., Mischoulon, D., Brown, R. P., Fava, M., & Streeter, C. C. (2018). A randomized controlled dosing study of Iyengar yoga and coherent breathing for the treatment of major depressive disorder: Impact on suicidal ideation and safety findings. Complementary Therapies in Medicine, 37, 136–142.

    Article  PubMed  Google Scholar 

  • Otero-Losada, M. E., & Rubio, M. C. (1989a). Acute changes in 5-HT metabolism after S-adenosyl-l-methionine administration. General Pharmacology, 20, 403–406.

    Article  CAS  PubMed  Google Scholar 

  • Otero-Losada, M. E., & Rubio, M. C. (1989b). Acute effects of S-adenosyl-l-methionine on catecholaminergic central function. European Journal of Pharmacology, 163, 353–356.

    Article  CAS  Google Scholar 

  • Panossian, A., & Amsterdam, D. (2017). Adaptogens in psychiatric practice. In P. L. Gerbarg, R. P. Brown, & P. R. Muskin (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 113–134). American Psychiatric Association Publishing.

    Google Scholar 

  • Panossian, A., & Wagner, H. (2005). Stimulating effect of adaptogens: An overview with particular reference to their efficacy following single dose administration. Phytotherapy Research, 19, 819–838.

    Article  CAS  PubMed  Google Scholar 

  • Panossian, A., Wikman, G., et al. (2010). Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine, 17(7), 481–493.

    Article  CAS  PubMed  Google Scholar 

  • Papakostas, G. I. (2006). Treatment-resistant major depressive disorder: New developments in 2006. Psychiatric Times, 23, 17–20.

    Google Scholar 

  • Papakostas, G. I., Mischoulon, D., et al. (2010). S-Adenosylmethionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: A double-blind, randomized clinical trial. American Journal of Psychiatry, 167(8), 942–948.

    Article  PubMed  Google Scholar 

  • Paul, M. A., Brown, G., Buguet, A., et al. (2001). Melatonin and zopiclone as pharmacologic aids to facilitate crew rest. Aviation, Space, and Environmental Medicine, 72(11), 974–984.

    CAS  PubMed  Google Scholar 

  • Payne, P., & Crane-Godreau, M. A. (2013). Meditative movement for depression and anxiety. Frontiers in Psychiatry, 4(71), 1–15.

    Google Scholar 

  • Pearson, N. J., Johnson, L. L., et al. (2006). Insomnia, trouble sleeping, and complementary and alternative medicine: Analysis of the 2002 national health interview survey data. Archives of Internal Medicine, 166(16), 1775–1782.

    Article  PubMed  Google Scholar 

  • Peet, M., Brind, J., Ramchand, C. N., et al. (2001). Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. Schizophrenia Research, 49(3), 243–251.

    Article  CAS  PubMed  Google Scholar 

  • Penninx, B. W., Guralnik, J. M., Ferrucci, L., et al. (2000). Vitamin B12 deficiency and depression in physically disabled older women: Epidemiologic evidence from the Women’s Health and Aging Study. American Journal of Psychiatry, 157, 715–721.

    Article  CAS  PubMed  Google Scholar 

  • Pettegrew, J. W., Levine, J., & McClure, R. J. (2000). Acetyl-l-carnitine physical-chemical, metabolic, and therapeutic properties: Relevance for its mode of action in Alzheimer’s disease and geriatric depression. Molecular Psychiatry, 5, 616–632.

    Article  CAS  PubMed  Google Scholar 

  • Philippot, P., Gaetane, C., & Blairy, S. (2002). Respiratory feedback in the generation of emotion. Cognition and Emotion, 16, 605–607.

    Article  Google Scholar 

  • Pilkington, K., Kirkwood, G., et al. (2007). Acupuncture for anxiety and anxiety disorders –a systematic literature review. Acupuncture in Medicine, 25(1–2), 1–10.

    Article  PubMed  Google Scholar 

  • Porges, S. W., & Carter, S. S. (2017). Polyvagal theory and the social engagement system. Neurophysiological bridge between connectedness and health. In P. L. Gerbarg, O. R. Muskin, & R. P. Brown (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 221–240). American Psychiatric Association Publishing.

    Google Scholar 

  • Prasad, A. S. (2009). Zinc: Role in immunity, oxidative stress and chronic inflammation. Current Opinion in Clinical Nutrition and Metabolic Care, 12(6), 646–652.

    Article  CAS  PubMed  Google Scholar 

  • Quiñones, N., Maquet, Y. G., Vélez, D. M., et al. (2015). Efficacy of a Satyananda Yoga intervention for reintegrating adults diagnosed with posttraumatic stress disorder. International Journal of Yoga Therapy, 25(1), 89–99.

    Article  PubMed  Google Scholar 

  • Rahimi, R., Nikfar, S., et al. (2009). Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors: A meta-analysis. Progress in Neuro Psychopharmacology and Biological Psychiatry, 33(1), 118–127.

    Article  CAS  PubMed  Google Scholar 

  • Raison, C. L., Capuron, L., & Miller, A. H. (2006). Cytokines sing the blues: Inflammation and the pathogenesis of depression. Trends in Immunology, 27, 24–31.

    Article  CAS  PubMed  Google Scholar 

  • Rao, N. P., Varambally, S., & Gangadhar, B. N. (2013). Yoga school of thought and psychiatry: Therapeutic potential. Indian Journal of Psychiatry, 55(Suppl 2), S145–S149.

    Article  PubMed  PubMed Central  Google Scholar 

  • Reay, J. L., Scholey, A. D., & Kennedy, D. O. (2010). Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults. Human Psychopharmacology, 25(6), 462–471.

    Article  CAS  PubMed  Google Scholar 

  • Richardson, A. J. (2006). Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. International Review of Psychiatry, 18, 155–172.

    Article  PubMed  Google Scholar 

  • Richter, Y., Herzog, Y., Lifshitz, Y., et al. (2013). The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: A pilot study. Clinical Interventions in Aging, 8, 557–563.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Riggs, K., Spiro, A., III, Tucker, K., et al. (1996). Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. American Journal of Clinical Nutrition, 63, 306–314.

    Article  CAS  PubMed  Google Scholar 

  • Ritsner, M. S., Miodownik, C., Ratner, Y., et al. (2011). l-Theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: An 8-week, randomized, double-blind, placebo-controlled, 2-center study. Journal of Clinical Psychiatry, 72(1), 34–42.

    Article  CAS  PubMed  Google Scholar 

  • Robbins, J. (2000). A symphony in the brain: The evolution of the new brain wave biofeedback. Grove Press.

    Google Scholar 

  • Romero-Cerecero, O., Islas-Garduño, A. L., Zamilpa, A., et al. (2019). Galphimine-B standardized extract versus alprazolam in patients with generalized anxiety disorder: A ten-week, double-blind, randomized clinical trial. BioMed Research International, 2019, 1037036.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rush, A. J., Trivedi, M. H., Wisniewski, S. R., et al. (2006). Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR*D report. American Journal of Psychiatry, 163, 1905–1917.

    Article  PubMed  Google Scholar 

  • Sakurai, H., Carpenter, L. L., & Tyrka, A. R. (2020). Dose increase of S-Adenosyl-methionine and escitalopram in a randomized clinical trial for major depressive disorder. Journal of Affective Disorders, 262, 118–125.

    Article  CAS  PubMed  Google Scholar 

  • Salehi, B., Imani, R., et al. (2010). Ginkgo biloba for attention-deficit/hyperactivity disorder in children and adolescents: A double blind, randomized controlled trial. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34(1), 76–80.

    Article  CAS  PubMed  Google Scholar 

  • Salgueiro, J. B., Ardenghi, P., et al. (1997). Anxiolytic natural and synthetic flavonoid ligands of the central benzodiazepine receptor have no effect on memory tasks in rats. Pharmacology, Biochemistry, and Behavior, 58(4), 887–891.

    Article  CAS  PubMed  Google Scholar 

  • Sanchez-Villegas, A., Henriquez, P., et al. (2007). Long chain omega-3 fatty acids intake, fish consumption and mental disorders in the SUN cohort study. European Journal of Nutrition, 46(6), 337–346.

    Article  CAS  PubMed  Google Scholar 

  • Saratikov, A. S., & Krasnov, E. A. (1987a). Effect of Rhodiola rosea on the central nervous system. In A. S. Saratikov & E. A. Krasnov (Eds.), Rhodiola Rosea is a valuable medicinal plant (Golden root) (pp. 150–179). Tomsk State University Press.

    Google Scholar 

  • Saratikov, A. S., & Krasnov, E. A. (1987b). Clinical studies of Rhodiola. In A. S. Saratikov & E. A. Krasnov (Eds.), Rhodiola Rosea is a valuable medicinal plant (Golden root) (pp. 216–227). Tomsk State University Press.

    Google Scholar 

  • Sarris, J. (2012). Current challenges in appraising complementary medicine evidence. Medical Journal of Australia, 196(5), 310–311.

    Article  PubMed  Google Scholar 

  • Sarris, J. (2013a). Ginkgo. In K. Bone & S. Mills (Eds.), Principles and practice of phytotherapy (2nd ed.). Churchill Livingstone Elsevier.

    Google Scholar 

  • Sarris, J. (2013b). St John’s wort for the treatment of psychiatric disorders. Psychiatric Clinics of North America, 36(1), 65–72.

    Article  PubMed  Google Scholar 

  • Sarris, J., & Byrne, G. J. (2011). A systematic review of insomnia and complementary medicine. Sleep Medicine Reviews, 15(2), 99–106.

    Article  PubMed  Google Scholar 

  • Sarris, J., Kavanagh, D. J., Byrne, G., et al. (2009a). The Kava Anxiety Depression Spectrum Study (KADSS): A randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum. Psychopharmacology, 205(3), 399–407.

    Article  CAS  PubMed  Google Scholar 

  • Sarris, J., Kavanagh, D. J., & Byrne, G. (2009b). Adjuvant use of nutritional and herbal medicines with antidepressants, mood stabilizers and benzodiazepines. Journal of Psychiatric Research, 44(1), 32–41.

    Article  PubMed  Google Scholar 

  • Sarris, J., Schoendorfer, N., et al. (2009c). Major depressive disorder and nutritional medicine: A review of monotherapies and adjuvant treatments. Nutrition Reviews, 67(3), 125–131.

    Article  PubMed  Google Scholar 

  • Sarris, J., Kean, J., Schweitzer, I., et al. (2011a). Complementary medicines (herbal and nutritional products) in the treatment of Attention Deficit Hyperactivity Disorder (ADHD): A systematic review of the evidence. Complementary Therapies in Medicine, 19(4), 216–227.

    Article  PubMed  Google Scholar 

  • Sarris, J., LaPorte, E., & Schweitzer, I. (2011b). Kava: A comprehensive review of efficacy, safety, and psychopharmacology. Australian and New Zealand Journal of Psychiatry, 45(1), 27–35.

    Article  PubMed  Google Scholar 

  • Sarris, J., Fava, M., et al. (2012a). St. John’s wort (Hypericum perforatum) versus sertraline and placebo in major depressive disorder: Continuation data from a 26 week RCT. Pharmacopsychiatry, 45(7), 275–278.

    Article  CAS  PubMed  Google Scholar 

  • Sarris, J., Mischoulon, D., et al. (2012b). Omega-3 for bipolar disorder: Meta-analyses of use in mania and bipolar depression. Journal of Clinical Psychiatry, 73(1), 81–86.

    Article  CAS  PubMed  Google Scholar 

  • Sarris, J., Glick, R., Hoenders, R. J., et al. (2013a). Integrative mental healthcare White Paper: Establishing a new paradigm through research, education, and clinical guidelines. Advances in Integrative Medicine, 1(1), 9–16.

    Google Scholar 

  • Sarris, J., McIntyre, E., & Carnfield, D. A. (2013b). Plant-based medicines for anxiety disorders. Part 2: A systematic review of clinical studies with supporting preclinical evidence. CNS Drugs, 27(4), 301–319.

    Article  CAS  PubMed  Google Scholar 

  • Sarris, J., Nierenberg, A. A., Schweitzer, I., et al. (2013c). Conditional probability of response or nonresponse of placebo compared with antidepressants or St John’s wort in major depressive disorder. Journal of Clinical Psychopharmacology, 33(6), 827–830.

    Article  PubMed  Google Scholar 

  • Sarris, J., Stough, C., et al. (2013d). Kava in the treatment of generalized anxiety disorder: A double-blind, randomized, placebo-controlled study. Journal of Clinical Psychopharmacology, 33(5), 643–648.

    Article  PubMed  Google Scholar 

  • Sarris, J., Papakostas, G., & Vitelos, et al. (2014). S-Adenosylmethionine (SAMe) versus escitalopram and placebo in major depression: Efficacy and effects of histamine and carnitine as moderators of response. Journal of Affective Disorders, 164, 76–81.

    Article  CAS  PubMed  Google Scholar 

  • Sarris, J., Oliver, G., Camfield, D. A., et al. (2015). N-acetyl cysteine (NAC) in the treatment of obsessive-compulsive disorder: A 16-week, double-blind, randomised, placebo-controlled study. CNS Drugs, 29(9), 801–809.

    Article  CAS  PubMed  Google Scholar 

  • Sarris, J., Byrne, G. J., Stough, C., et al. (2019a). Nutraceuticals for major depressive disorder- more is not merrier: An 8-week double-blind, randomised, controlled trial. Journal of Affective Disorders, 245, 1007–1015.

    Article  PubMed  Google Scholar 

  • Sarris, J., Byrne, G. J., Bousman, C. A., et al. (2019b). Kava for generalised anxiety disorder: A 16-week double-blind, randomized, placebo-controlled study. The Australian and New Zealand Journal of Psychiatry, 54(3), 288–229.

    Article  PubMed  Google Scholar 

  • Sarris, J., Murphey, S. C., et al. (2020). S-Adenosylmethionine (SAMe) monotherapy for depression: An 8-week double-blind, randomised, controlled trial. Psychopharmacology, 237(1), 209–218.

    Article  CAS  PubMed  Google Scholar 

  • Sarris, J., Wolfgang, M., Ashton, M. M., et al. (2021). Plant-based medicines (Phytoceuticals) in the treatment of psychiatric disorders: A meta-review of meta-analyses of randomized controlled trials. The Canadian Journal of Psychiatry (in press).

    Google Scholar 

  • Satyanarayana, M., Rajeswari, K. R., Rani, N. J., et al. (1992). Effect of Santhi Kriya on certain psychophysiological parameters: A preliminary study. Indian Journal of Physiology and Pharmacology, 36(2), 88–92.

    CAS  PubMed  Google Scholar 

  • Schardt, D. (2000). St. John’s worts and all. Nutrition Action Healthletter, September, 6–8.

    Google Scholar 

  • Schaumburg, H. H., & Berger, A. (1992). Alopecia and sensory polyneuropathy from thallium in a Chinese herbal medication. JAMA, 268, 3430–3431.

    Article  CAS  PubMed  Google Scholar 

  • Schefft, C., Kilarski, L. L., Bschor, T., et al. (2017). Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis. European Neuropsychopharmacology, 27(11), 1090–1109.

    Article  CAS  PubMed  Google Scholar 

  • Schellenberg, R., Sauer, S., & Dimpfel, W. (1998). Pharmacodynamic effects of two different hypericum extracts in healthy volunteers measured by quantitative EEG. Pharmacopsychiatry, 31(Suppl 1), 44–53.

    Article  CAS  PubMed  Google Scholar 

  • Schmidt, M., Betti, G., & Hensel, A. (2007). Saffron in phytotherapy: Pharmacology and clinical uses. Wiener Medizinische Wochenschrift, 157(13–14), 315–319.

    Article  PubMed  Google Scholar 

  • Scholey, A. B., Tildesley, N. T., Ballard, C. G., et al. (2008). An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology, 198(1), 127–139.

    Article  CAS  PubMed  Google Scholar 

  • Scholey, A., Ossoukhova, A., Owen, L., Ibarra, A., Pipingas, A., He, K., Roller, M., & Stough, C. (2010). Effects of American ginseng (Panax quinquefolius) on neurocognitive function: An acute, randomised, double-blind, placebo-controlled, crossover study. Psychopharmacology, 212(3), 345–356. https://doi.org/10.1007/s00213-010-1964-y. Epub 2010 Jul 31. PMID: 20676609; PMCID: PMC2952762.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schweitzer, I., Maguire, K., et al. (2009). Sexual side-effects of contemporary antidepressants: Review. Australian and New Zealand Journal of Psychiatry, 43(9), 795–808.

    Article  PubMed  Google Scholar 

  • Scuteri, D., Morrone, L. A., Rombola, L., et al. (2017). Aromatherapy and aromatic plants for the treatment of behavioural and psychological symptoms of dementia in patients with Alzheimer’s disease: Clinical evidence and possible mechanisms. Evidence-based Complementary and Alternative Medicine, 2017, 1–30.

    Article  Google Scholar 

  • Seshadri, A., Adaji, A., Orth, S. S., et al. (2020). Exercise, Yoga, and Tai Chi for treatment of major depressive disorder in outpatient settings: A systematic review and meta-analysis. Primary Care Companion Central Nervous System Disorders, 23(1), 20r02722.

    Google Scholar 

  • Shakibaei, F., Radmanesh, M., Salari, E., et al. (2015). Ginkgo biloba in the treatment attention-deficit/hyperactivity disorder in children and adolescents. A randomized, placebo-controlled trial. Complementary Therapies in Clinical Practice, 21(2), 61–67.

    Article  PubMed  Google Scholar 

  • Shamir, E., Laudon, M., Barak, Y., et al. (2000). Melatonin improves sleep quality of patients with chronic schizophrenia. Journal of Clinical Psychiatry, 61, 373–377.

    Article  CAS  PubMed  Google Scholar 

  • Sharma, A., Gerbarg, P., Bottiglieri, T., et al. (2017). S-Adenosylmethionine (SAMe) for neuropsychiatric disorders: A clinician-oriented review of research. Journal of Clinical Psychiatry, 78(6), e656–e667.

    Article  PubMed  Google Scholar 

  • Shaw, K., Turner, J., & Del Mar, C. (2002). Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysis. Australian and New Zealand Journal of Psychiatry, 36(4), 488–491.

    Article  PubMed  Google Scholar 

  • Shevtsov, V. A., Zholus, B. I., Shervarly, V. I., et al. (2003). A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine, 10(2–3), 95–105.

    Article  CAS  PubMed  Google Scholar 

  • Shimada, Y., Arai, T., Tamaoka, A., et al. (2017). Liquorice-induced hypokalaemia in patients treated with Yokukansan preparations: Identification of the risk factors in a retrospective cohort study. BMJ Open, 7, e014218.

    Article  PubMed  PubMed Central  Google Scholar 

  • Shimada, Y., Fujimioto, M., Nogami, T., et al. (2019). Adverse events associated with ethical Kampo formulations: Analysis of domestic adverse-event data reports of the Ministry of Health, Labor, and Welfare in Japan. Evidence-based Complementary and Alternative Medicine, 2019, 1–14, 1643804.

    Article  Google Scholar 

  • Shinjyo, N., Waddell, G., & Green, J. (2020). Valerian root in treating sleep problems and associated disorders-a systematic review and meta-analysis. Journal of Evidence Based Integrative Medicine, 25, 2515690X20967323.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Singh, Y. N., & Devkota, A. K. (2003). Aqueous kava extracts do not affect liver function tests in rats. Planta Medica, 69, 496–499.

    Article  CAS  PubMed  Google Scholar 

  • Singh, S. P., & Singh, V. (2011). Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia. CNS Drugs, 25(10), 859–885.

    Article  CAS  PubMed  Google Scholar 

  • Singh, S. P., Telles, S., & Balkrishna. (2017). Use of yoga in managing posttraumatic stress disorder. In P. L. Gerbarg, R. P. Brown, & P. R. Muskin (Eds.), Complementary and integrative treatments in psychiatric practice (pp. 251–260). American Psychiatric Association Publishing.

    Google Scholar 

  • Sinn, N., & Bryan, J. (2007). Effect of supplementation with polyunsaturated fatty acids and micronutrients on learning and behavior problems associated with child ADHD. Journal of Developmental and Behavioral Pediatrics, 28(2), 82–91.

    Article  PubMed  Google Scholar 

  • Small, G. W., Siddarth, P., Zhaoping, L., et al. (2018). Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: A double-blind placebo-controlled 18-month trail. American Journal of Geriatric Psychiatry, 23(3), 266–277.

    Article  Google Scholar 

  • Smith, A. D., Smith, A. M., & de Jager, C. A. (2010). Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: A randomized controlled trial. PLoS One, 5(9), e12244.

    Article  PubMed  PubMed Central  Google Scholar 

  • Smith, R. C., Boules, S., Maayan, L., et al. (2013). Effects of yoga on cognition, psychiatric symptoms, and epigenetic changes in chronic schizophrenic patients. Presented at the 14th international schizophrenia congress, Orlando, FL, 22 April 2013.

    Google Scholar 

  • Smith, C. A., Armour, M., Lee, M. S., et al. (2018). Acupuncture for depression (review). Cochrane Database of Systematic Reviews, 3(3), CD004046.

    PubMed  Google Scholar 

  • Soares-Weiser, K., Maayan, N., & Bergman, H. (2018). Vitamin E for neuroleptic-induced tardive dyskinesia. Cochrane Database of Systematic Reviews, (1), CD000209.

    Google Scholar 

  • Sonuga-Barke, E. J., Brandeis, D., Cortese, S., et al. (2013). Nonpharmacological interventions for ADHD: Systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments. American Journal of Psychiatry, 170(3), 275–289.

    Article  PubMed  Google Scholar 

  • Sorensen, H., & Sonne, J. (1996). A double-masked study of the effects of ginseng on cognitive functions. Current Therapeutic Research, 57, 959–968.

    Article  Google Scholar 

  • Stevens, L. J., Zentall, S. S., Deck, J. L., et al. (1995). Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. American Journal of Clinical Nutrition, 62, 761–768.

    Article  CAS  PubMed  Google Scholar 

  • Stevenson, J., Sonuga-Barke, E., McCann, D., et al. (2010). The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children’s ADHD symptoms. American Journal of Psychiatry, 167(9), 1108–1115.

    Article  PubMed  Google Scholar 

  • Stratyner, H. B. (2006). Multi-factorial approaches to substance use disorders and addiction. CNS Spectrums, 11, 828.

    Article  Google Scholar 

  • Streeter, C. C., Gerbarg, P. L., Saper, R. B., et al. (2012). Effects of yoga on the autonomic nervous system, gamma-aminobutyric acid, and allostasis in epilepsy, depression, and posttraumatic stress disorder. Medical Hypotheses, 78(5), 571–579.

    Article  CAS  PubMed  Google Scholar 

  • Streeter, C. C., Gerbarg, P. L., Brown, R. P., et al. (2020a). Thalamic gamma aminobutyric acid level changes in major depressive disorder after a 12-week Iyengar yoga and coherent breathing intervention. Journal of Alternative and Complementary Medicine, 26(3), 190–197.

    Article  PubMed  PubMed Central  Google Scholar 

  • Streeter, C. C., Gerbarg, P. L., Nyer, M. B., et al. (2020b). Yoga: Part of a treatment plan for uncontrolled epilepsy. Journal of Neurological Disorders and Stroke, 7(1), 1156–1162.

    Google Scholar 

  • Suhner, A., Schlagenhauf, P., Johnson, R., et al. (1998). Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiology International, 15(6), 655–666.

    Article  CAS  PubMed  Google Scholar 

  • Szegedi, A., Kohnen, R., Dienel, A., et al. (2005). Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John’s wort): Randomised controlled double blind non-inferiority trial versus paroxetine. BMJ, 330, 503.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Szewczyk, B., Kubera, M., et al. (2011). The role of zinc in neurodegenerative inflammatory pathways in depression. Progress in Neuro Psychopharmacology and Biological Psychiatry, 35(3), 693–701.

    Article  CAS  PubMed  Google Scholar 

  • Takeda, A. (2011). Zinc signaling in the hippocampus and its relation to pathogenesis of depression. Molecular Neurobiology, 44(2), 166–174.

    Article  CAS  PubMed  Google Scholar 

  • Targum, S. D., Cameron, B. R., & Ferreira, et al. (2018). An augmentation study of MSI-195 (S-adenosylmethionine) in major depressive disorder. Journal of Psychiatric Research, 107, 86–96.

    Article  PubMed  Google Scholar 

  • Telles, S., & Singh, N. (2013). Science of the mind: Ancient yoga texts and modern studies. Psychiatric Clinics of North America, 36(1), 93–108.

    Article  PubMed  Google Scholar 

  • Telles, S., Nagarathna, R., Nagendra, H. R., et al. (1993). Physiological changes in sports teachers following 3 months of training in yoga. Indian Journal of Medical Science, 47(10), 235–238.

    CAS  Google Scholar 

  • Teschke, R., Sarris, J., et al. (2011). Kava, the anxiolytic herb: Back to basics to prevent liver injury? British Journal of Clinical Pharmacology, 71(3), 445–448.

    Article  PubMed  PubMed Central  Google Scholar 

  • Thiele, B., Brink, I., & Ploch, M. (1994). Modulation of cytokine expression by hypericum extract. Journal of Geriatric Psychiatry and Neurology, 7(Suppl 1), S60–S62.

    Article  PubMed  Google Scholar 

  • Tildesley, N. T., Kennedy, D. O., Perry, E. K., et al. (2005). Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers. Physiology and Behavior, 83(5), 699–709.

    Article  CAS  PubMed  Google Scholar 

  • Tolahunase, M., Sager, R., Faiq, M., et al. (2018a). Yoga- and meditation-based lifestyle intervention increases neuroplasticity and reduces severity of major depressive disorder: A randomized controlled trial. Restorative Neurology and Neuroscience, 36(3), 423–442.

    Article  CAS  PubMed  Google Scholar 

  • Tolahunase, M., Sager, R., Dada, R., et al. (2018b). 5-HTTLPR and MTHFR 677C>T polymorphisms and response to a yoga-based lifestyle intervention in major depressive disorder: A randomized active-controlled trial. Indian Journal of Psychiatry, 60(4), 410–426.

    Article  PubMed  PubMed Central  Google Scholar 

  • Torrioli, M. G., Vernacotola, S., et al. (2008). A double-blind, parallel, multicenter comparison of l-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys. American Journal of Medical Genetics, Part A, 146(7), 803–812.

    Article  Google Scholar 

  • Torta, R., Zanalda, F., Rocca, P., et al. (1988). Inhibitory activity of S-adenosyl-l-methionine on serum gamma-glutamyl-transpeptidase increase induced by psychodrugs and anticonvulsants. Current Therapeutic Research, 44, 144–159.

    Google Scholar 

  • Trebatická, J., Kopasova, S., Hradecna, Z., et al. (2006). Treatment of ADHD with French maritime pine bark extract, pycnogenol. European Child and Adolescent Psychiatry, 15, 329–335.

    Article  PubMed  Google Scholar 

  • Tsang, H. W., Fung, K. M., Chan, A. S., et al. (2006). Effect of a qigong exercise programme on elderly with depression. International Journal of Geriatric Psychiatry, 21(9), 890–897.

    Article  PubMed  Google Scholar 

  • US Department of Health and Human Services Agency for Healthcare Research and Quality. (2002). S-Adenosyl-l-methionine for treatment of depression, osteoarthritis, and liver disease. Evidence report/technology assessment no. 64. https://www.ncbi.nlm.nih.gov/books/NBK11886/. Accessed 17 Feb 2022.

  • Vaisman, N., Kaysar, N., & Zaruk-Adasha, Y. (2008). Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: Effect of dietary n-3 fatty acids containing phospholipids. American Journal of Clinical Nutrition, 87(5), 1170–1180.

    Article  CAS  PubMed  Google Scholar 

  • Vancampfort, D., Stubbs, B., Van Damme, T., et al. (2021). The efficacy of meditation-based mind-body interventions for mental disorders: A meta-review of 17 meta-analyses of randomized controlled trials. Journal of Psychiatric Research, 134, 181–191.

    Article  PubMed  Google Scholar 

  • Varambally, S., Gangadhar, B. N., Thirthalli, J., et al. (2012). Therapeutic efficacy of add-on yogasana intervention in stabilized outpatient schizophrenia: Randomized controlled comparison with exercise and waitlist. Indian Journal of Psychiatry, 54, 227–232.

    Article  PubMed  PubMed Central  Google Scholar 

  • Varteresian, T., & Lavretsky, H. (2018). Complementary and integrative therapies in psychiatry. Focus, 16(1), 54–56.

    Article  PubMed  PubMed Central  Google Scholar 

  • Vaschillo, E., Vaschillo, B., & Lehrer, P. (2004). Heartbeat synchronizes with respiratory rhythm only under specific circumstances. Chest, 126, 1385–1386.

    Article  PubMed  Google Scholar 

  • Vellas, B., Coley, N., Ousset, P. J., et al. (2012). Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer’s disease (GuidAge): A randomised placebo-controlled trial. Lancet Neurology, 11(10), 851–859.

    Article  CAS  PubMed  Google Scholar 

  • Visceglia, E. (2007). Healing mind and body: Using therapeutic yoga in the treatment of schizophrenia. International Journal of Yoga Therapy, 17, 95–102.

    Article  Google Scholar 

  • Visceglia, E., & Lewis, S. (2011). Yoga therapy as an adjunctive treatment for schizophrenia: A randomized, controlled pilot study. Journal of Alternative and Complementary Medicine, 17, 601–607.

    Article  PubMed  Google Scholar 

  • Voelker, R. (1999). Herbs and anethesia. JAMA, 281, 1882.

    Article  Google Scholar 

  • Vorbach, E. U., Arnoldt, K. H., & Hubner, W. D. (1997). Efficacy and tolerability of St. John’s wort extract LI 160 versus imipramine in patients with severe depressive episodes according to ICD-10. Pharmacopsychiatry, 30(Suppl 2), 81–85.

    Article  CAS  PubMed  Google Scholar 

  • Vuong, Q. V., Bowyer, M. C., et al. (2011). l-Theanine: Properties, synthesis and isolation from tea. Journal of the Science of Food and Agriculture, 91(11), 1931–1939.

    Article  CAS  PubMed  Google Scholar 

  • Wang, S. M., Kain, Z. N., et al. (2008). Acupuncture analgesia: I. The scientific basis. Anesthesia and Analgesia, 106(2), 602–610.

    Article  PubMed  Google Scholar 

  • Wang, C., Li, K., Seo, D.-C., et al. (2020). Use of complementary and alternative medicine in children with ADHD: Results from the 2012 and 2017 National Health Interview Survey. Complementary Therapies in Medicine, 49, 102352.

    Article  PubMed  Google Scholar 

  • Weber, W., Vander Stoep, A., et al. (2008). Hypericum perforatum (St John’s wort) for attention-deficit/hyperactivity disorder in children and adolescents: A randomized controlled trial. JAMA, 299(22), 2633–2641.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • White, D. J., Camfield, D. A., Ossoukhova, A., Savage, K., Le Cozannet, R., Fança-Berthon, P., & Scholey, A. (2020). Effects of Panax quinquefolius (American ginseng) on the steady state visually evoked potential during cognitive performance. Human Psychopharmacology, 35(6), 1–6. https://doi.org/10.1002/hup.2756. Epub 2020 Sep 8. PMID: 32896022; PMCID: PMC7685123.

    Article  CAS  PubMed  Google Scholar 

  • Whitten, D., Myers, D., et al. (2006). The effect of St John’s wort extracts on CYP3A: A systematic review of prospective clinical trials. British Journal of Clinical Pharmacology, 62(5), 512–526.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Willatts, P., Forsyth, J. S., DiModugno, M. K., et al. (1998). Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age. The Lancet, 352, 688–691.

    Article  CAS  Google Scholar 

  • Williams, A. L., Katz, D., et al. (2006). Do essential fatty acids have a role in the treatment of depression? Journal of Affective Disorders, 93(1–3), 117–123.

    Article  CAS  PubMed  Google Scholar 

  • Yang, X.-Y., Yang, N.-B., & Huang, F. F. (2021). Effectiveness of acupuncture on anxiety disorder: A systematic review and meta-analysis of randomised controlled trials. Annals of General Psychiatry, 20(9), 1–14.

    Google Scholar 

  • Yary, T., & Aazami, S. (2012). Dietary intake of zinc was inversely associated with depression. Biological Trace Element Research, 145(3), 286–290.

    Article  CAS  PubMed  Google Scholar 

  • Yeung, W. F., Chung, K. F., & Leung, Y. K. (2009). Traditional needle acupuncture treatment for insomnia: A systematic review of randomized controlled trials. Sleep Medicine, 10(7), 694–704.

    Article  PubMed  Google Scholar 

  • Yolland, C. O., Phillipou, A., & Castle, D. (2020). Improvement of cognitive function in schizophrenia with N-acetylcysteine: A theoretical review. Nutrition Neuroscience, 23(2), 139–148.

    Article  CAS  Google Scholar 

  • Youdim, K. A., Martin, A., & Joseph, J. A. (2000). Essential fatty acids and the brain: Possible health implications. International Journal of Developmental Neuroscience, 18, 383–399.

    Article  CAS  PubMed  Google Scholar 

  • Zaccaro, A., Piarulli, A., Laurino, M., et al. (2018). How breath-control can change your life: A systematic review on psycho-physiological correlates of slow breathing. Frontiers in Human Neuroscience, 12, 353–369.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zanardi, R., & Smeraldi, E. (2006). A double-blind, randomised, controlled clinical trial of acetyl-l-carnitine vs. amisulpride in the treatment of dysthymia. European Neuropsychopharmacology, 16, 281–287.

    Article  CAS  PubMed  Google Scholar 

  • Zandi, P. P., Anthony, J. C., Khachaturian, A. S., et al. (2004). Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: The Cache County Study. Archives of Neurology, 61, 82–88.

    Article  PubMed  Google Scholar 

  • Zhang, X. Y., Zhou, D. F., Zhang, P. Y., et al. (2001). A double-blind, placebo-controlled trial of extract of Ginkgo biloba added to haloperidol in treatment-resistant patients with schizophrenia. Journal of Clinical Psychiatry, 62, 878–883.

    Article  CAS  PubMed  Google Scholar 

  • Zhdanova, I. V., Wurtman, R. J., Regan, M. M., et al. (2001). Melatonin treatment for age-related insomnia. Journal of Clinical Endocrinology and Metabolism, 86, 4727–4730.

    Article  CAS  PubMed  Google Scholar 

  • Zhou, Y., Hou, Y., Shen, J., et al. (2020). A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. PLoS Biology, 18(11), e3000970.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zylowska, L. (2012). The mindfulness prescription for adult ADHD. Trumpeter Books.

    Google Scholar 

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Acknowledgments

Prof Jerome Sarris is funded by an Australian National Health & Medical Research Council fellowship (NHMRC funding ID 1125000).

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Sarris, J., Gerbarg, P.L., Brown, R.P., Muskin, P.R. (2023). Integrative and Complementary Medicine in Psychiatry. In: Tasman, A., et al. Tasman’s Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-030-42825-9_145-1

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