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Sigma Factors of RNA Polymerase in Corynebacterium glutamicum

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Corynebacterium glutamicum

Part of the book series: Microbiology Monographs ((MICROMONO,volume 23))

Abstract

Corynebacterium glutamicum is an important biotechnological organism as well as a model organism for other corynebacteria including pathogenic species. C. glutamicum also seems suitable as a model organism for corynebacteria in respect of studies of regulatory networks controlled by sigma factors of RNA polymerase, because its sigma factors represent a common subset, which was found in most Corynebacterium species. The C. glutamicum genome encodes seven σ factors: A primary σA, a primary-like σB and five σ factors of the extracytoplasmic function (ECF) group (σC, σD, σE, σH and σM) that are involved in various stress responses. Activities of σD, σE and σH are controlled by the cognate anti-sigma factors.

Activities of ECF sigma factors in response to heat, cold, cell surface and oxidative stresses, DNA damage, growth phases, nutritional limitations and chemostresses caused by various harmful substances often overlap. Most of the consensus sequences of different promoter classes recognized by individual sigma factors have been defined. C. glutamicum sigma factors σA and σB initiate transcription from nearly identical promoters and their recognition specificity probably depends largely on physiological conditions. Comparison of consensus sequences of promoters recognized by ECF sigma factors indicates that they are mutually similar to various extent and recognition specificities of these sigma factors may also overlap.

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Acknowledgements

This work was supported by Grant 17-06991S from the Czech Science Foundation, Mobility Grant DAAD-18-11 from Czech Academy of Sciences (CAS) and Deutscher Akademischer. Austauschdienst and Institutional Research Project RVO61388971 from the Institute of Microbiology of the CAS.

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  1. Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic

    Miroslav Pátek, Hana Dostálová & Jan Nešvera

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  1. Miroslav Pátek
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Correspondence to Miroslav Pátek .

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  1. Molecular Microbiology and Biotechnology, Research Institute of Innovative Technology, Kyoto, Japan

    Masayuki Inui

  2. Molecular Microbiology and Biotechnology, Research Institute of Innovative Technology, Kyoto, Japan

    Koichi Toyoda

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Pátek, M., Dostálová, H., Nešvera, J. (2020). Sigma Factors of RNA Polymerase in Corynebacterium glutamicum . In: Inui, M., Toyoda, K. (eds) Corynebacterium glutamicum. Microbiology Monographs, vol 23. Springer, Cham. https://doi.org/10.1007/978-3-030-39267-3_4

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