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Best Practice Guidelines for Sperm DNA Fragmentation Testing

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Male Infertility

Abstract

The field of male infertility has witnessed many advancements in the past few decades that have refined our understanding of the sperm contribution to conception. The extent of sperm DNA fragmentation is currently believed to play a key role on fertilization and embryogenesis making it an important test of sperm function. This belief has triggered many scientists to explore SDF testing in clinical practice. Many tests can assess DNA damage directly through dyes and probes or indirectly though measuring the denaturation of DNA. Regardless of the method used, SDF testing is gaining popularity and is extensively investigated to evaluate its value in the management of male infertility. Recent publication of clinical practice guidelines on the utility of SDF testing has provided a strong evidence-based approach to the utilization of this test by fertility specialists. This chapter aims at exploring the evidence highlighting the significance of SDF testing in clinical practice.

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Authors and Affiliations

  1. Department of Urology, Hamad Medical Corporation, Weill Cornell Medicine Qatar, Doha, Qatar

    Ahmad Majzoub

  2. American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA

    Ashok Agarwal

  3. Department of Surgery, Union Hospital, Tai Wai, Hong Kong

    Chak-Lam Cho

  4. ANDROFERT and State University of Campinas (UNICAMP), Campinas, Brazil

    Sandro C. Esteves

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  1. Ahmad Majzoub
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  2. Ashok Agarwal
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  3. Chak-Lam Cho
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  4. Sandro C. Esteves
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Editors and Affiliations

  1. PUR Clinic, University of Central Florida (UCF), Clermont, FL, USA

    Sijo J. Parekattil

  2. ANDROFERT and State University of Campinas (UNICAMP), Campinas, Brazil

    Sandro C. Esteves

  3. Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA

    Ashok Agarwal

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Majzoub, A., Agarwal, A., Cho, CL., Esteves, S.C. (2020). Best Practice Guidelines for Sperm DNA Fragmentation Testing. In: Parekattil, S., Esteves, S., Agarwal, A. (eds) Male Infertility. Springer, Cham. https://doi.org/10.1007/978-3-030-32300-4_63

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