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Magnetic/Superparamagnetic Hyperthermia as an Effective Noninvasive Alternative Method for Therapy of Malignant Tumors

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Abstract

Superparamagnetic hyperthermia (SPMHT) is noninvasive, nontoxic, and with increased efficiency in destroying malignant tumors compared with magnetic hyperthermia (MHT), and conventional chemo- and radiotherapy (RT) currently used in medical clinics in this issue. Nowadays SPMHT appears as the most promising alternative method in future therapy of cancer. In this chapter, SPMHT/MHT with bioencapsulated/biofunctionalized ferrimagnetic nanoparticles, best suited for this therapy, and the recent significant results obtained in vitro and in vivo on different animal models and for different types of cancers with high incidence among the people, with the greatest potential for application in clinical trials, will be presented. Moreover, the new concept of nanotheranostic as a result of advanced nanobiotechnology for increasing the efficiency in cancer therapy to 100% and nontoxicity on the heath tissues also will be presented.

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Abbreviations

2-DG:

2-Deoxyglucose

5-FU:

5-Fluorouracil (anticancer drug)

ADR:

Drug-resistive cancer cells

AMF:

Alternating magnetic field

ATA:

Aminoterephthalic acid

Bio-FiMNPs:

Biocompatible ferrimagnetic nanoparticles

Bio-MNPs:

Biocompatible magnetic nanoparticles

Bio-SPMNPs:

Biocompatible superparamagnetic nanoparticles

CDs:

Cyclodextrins

CMC:

Carboxymethyl cellulose

CT:

Computed tomography

Cy7:

Cyanine7 (lipophilic fluorescent dye)

DOX:

Doxorubicin (anticancer drug)

FiM:

Ferrimagnetic

FiMNPs:

Ferrimagnetic nanoparticles

FIMO:

Ferromagnetic iron-manganese oxide

FITC:

Fluorescent nanoparticles for imaging

FMI:

Fluorescence molecular imaging

HAP:

Hydroxyapatite

HER:

Herceptin

HPMC:

Hydroxyl-propyl methyl cellulose

IONPs:

Iron oxide nanoparticles

IR:

Infrared

Ls:

Liposome

MagTSLs:

Thermo-sensitive magnetoliposomes

MCL:

Magnetic cationic liposomes

MFHT:

Magnetic fluid hyperthermia

mHAP:

Magnetic hydroxyapatite

MHT:

Magnetic hyperthermia

MNCs:

Micellar magnetic nanoclusters

MNPs:

Magnetic nanoparticles

MRI:

Magnetic resonance imaging

MTB:

Magnetic tactic bacteria

MTT:

MTT assay

MTX:

Methotrexate

NFs:

Nano-flowers

NIR:

Near-infrared

NMHT:

Nano-magnetic hyperthermia

NPs:

Nanoparticles

NPTT:

Nano-photothermal therapy

OA:

Oleic acid

PAI:

Photoacoustic imaging

PBS:

Phosphate buffer solution

PDT:

Photodynamic therapy

PEG:

Polyethylene glycol

PES:

Poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate)

PET:

Positron emission tomography

PM:

Polymeric micelle

PSA:

Prostate-specific antigen

PVA:

Polyvinyl alcohol

ROS:

Reactive oxygen specie

RT:

Radiotherapy

SAR:

Specific absorption rate

SERS:

Surface-enhanced Raman scattering

SPECT:

Single-photon emission computed tomography

SPIONs:

Superparamagnetic iron oxide nanoparticles

SPM:

Superparamagnetic relaxation

SPMHT:

Superparamagnetic hyperthermia

SPMNPs:

Superparamagnetic nanoparticles

TA:

Terephthalic acid

US:

Ultrasound

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Authors and Affiliations

  1. Department of Physics, West University of Timisoara, Timisoara, Romania

    Costica Caizer

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Correspondence to Costica Caizer .

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  1. Department of Biotechnology, Nanobiotechnology Laboratory, Amravati, Maharashtra, India, Department of Chemistry, Federal University of Piauí, Teresina, Piauí, Brazil

    Mahendra Rai

  2. Department of DMLS, University of Lahore, Islamabad, Pakistan

    Bushra Jamil

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Caizer, C. (2019). Magnetic/Superparamagnetic Hyperthermia as an Effective Noninvasive Alternative Method for Therapy of Malignant Tumors. In: Rai, M., Jamil, B. (eds) Nanotheranostics. Springer, Cham. https://doi.org/10.1007/978-3-030-29768-8_14

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