Abstract
A major goal of geroscience is to achieve the ability to predict the rate of aging using biomarkers for the purpose of extending lifespan and healthspan. Chronological aging is not a suitable marker as it does not capture the true status of age-related changes. So far, there is no biomarker or combination of biomarkers that has emerged even though some have shown promise. In this chapter, we summarize novel cellular, protein, and DNA-related biomarkers for biological aging that can be found specifically in the circulation “for the life of every living thing is in the blood”.
H. Zhang and B. Wang—Joint-first authors.
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Abbreviations
- AD:
-
Alzheimer’s disease
- APP:
-
Amyloid precursor protein
- AMAR:
-
Apparent methylomic aging rate
- AFR:
-
Ascorbate free radical
- B2M:
-
Β2 microglobulin
- BoA:
-
Biomarker of aging
- BBB:
-
Blood-brain barrier
- CR:
-
Caloric restriction
- CNS:
-
Central nervous system
- CSF:
-
Cerebrospinal fluid
- CAD:
-
Coronary artery disease
- DNA methylation:
-
DNAm
- DHA:
-
Docosahexaenoic acid
- ECs:
-
Endothelial cells
- EVs:
-
Extracellular vesicles
- FGFR:
-
Fibroblast growth factor receptor
- GDF:
-
Growth differentiation factor
- IDO:
-
Indoleamine 2,3-dioxygenase enzyme
- LTL:
-
Leukocyte telomere length
- OPCs:
-
Oligodendrocyte progenitor cells
- PBMCs:
-
Peripheral blood mononuclear cells
- ROS:
-
Reactive oxygen species
- RBCs:
-
Red blood cells
- rLTL:
-
Relative leukocyte telomere length
- rTL:
-
Relative telomere length
- SAA:
-
Serum amyloid A
- SORL1:
-
Sortilin related receptor 1
- SOD:
-
Superoxide dismutase
- TL:
-
Telomere length
- VCAM1:
-
Vascular cell adhesion molecule 1
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Zhang, H., Wang, B., Jin, K. (2019). Circulating Biomarkers of Aging. In: Moskalev, A. (eds) Biomarkers of Human Aging. Healthy Ageing and Longevity, vol 10. Springer, Cham. https://doi.org/10.1007/978-3-030-24970-0_21
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