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Unfolded Protein Response: Cause or Consequence of Lipid and Lipoprotein Metabolism Disturbances?

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Bioactive Lipids in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1127))

Abstract

The liver plays a capital role in the control of whole body energy homeostasis through the metabolization of dietary carbohydrates and lipids. However, under excess macronutrient uptake, those pathways overcharge nucleus-to-endoplasmic reticulum (ER) traffic pathways, leading to luminal overload of unfolded proteins which activates a series of adaptive signaling pathways known as unfolded protein response (UPR). The UPR is a central network mechanism for cellular stress adaptation, however far from a global nonspecific all-or-nothing response. Such a complex signaling network is able to display considerable specificity of responses, with activation of specific signaling branches trimmed for distinct types of stimuli. This makes the UPR a fundamental mechanism underlying metabolic processes and diseases, especially those related to lipid and carbohydrate metabolism. Thus, for a better understanding of the role of UPR on the physiopathology of lipid metabolism disorders, the concepts discussed along this chapter will demonstrate how several metabolic derangements activate UPR components and, in turn, how UPR triggers several metabolic adaptations through its component signaling proteins. This dual role of UPR on lipid metabolism will certainly foment the pursuit of an answer for the question: is UPR cause or consequence of lipid and lipoprotein metabolism disturbances?

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Authors and Affiliations

  1. Laboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão, São Luís, Brazil

    Bruno Araújo Serra Pinto, Lucas Martins França & Antonio Marcus de Andrade Paes

  2. Laboratory of Vascular Biology, Heart Institute of the School of Medicine, University of São Paulo, São Paulo, Brazil

    Francisco Rafael Martins Laurindo

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  1. Bruno Araújo Serra Pinto
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  2. Lucas Martins França
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  3. Francisco Rafael Martins Laurindo
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  4. Antonio Marcus de Andrade Paes
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Correspondence to Antonio Marcus de Andrade Paes .

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  1. Departamento de Bioquímica and Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

    Andres Trostchansky

  2. Departamento de Bioquímica and Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

    Homero Rubbo

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Pinto, B.A.S., França, L.M., Laurindo, F.R.M., Paes, A.M.d.A. (2019). Unfolded Protein Response: Cause or Consequence of Lipid and Lipoprotein Metabolism Disturbances?. In: Trostchansky, A., Rubbo, H. (eds) Bioactive Lipids in Health and Disease. Advances in Experimental Medicine and Biology, vol 1127. Springer, Cham. https://doi.org/10.1007/978-3-030-11488-6_5

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