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HPV-Associated Oropharyngeal Cancer in the HIV/AIDS Patient

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Book cover HIV/AIDS-Associated Viral Oncogenesis

Part of the book series: Cancer Treatment and Research ((CTAR,volume 177))

Abstract

Since their discovery as the etiologic agents of cervical cancer in the mid-1970s, human papillomaviruses (HPVs) have been linked with a growing number of epithelial-derived tumors, including head and neck squamous cell carcinomas. HPV demonstrates a particular predilection for causing tumors of the oropharynx, with the majority of cases involving infection with high-oncogenic risk HPV-16. People living with HIV are at increased risk of infection with HPV- and HPV-related oral complications even with adequate control of their HIV infection with antiretroviral therapy. In this chapter, we discuss the molecular mechanisms that underlie HPV-mediated oncogenesis in the oropharynx. We also describe the progress that has been made in understanding the epidemiology of oral HPV infection and the determinants of oral HPV-related pathology. Finally, we examine what can be done to treat and prevent oral HPV infection, benign lesions, and cancer, particularly in the context of the HIV-positive patient.

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Authors and Affiliations

  1. Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, 1901 Perdido St. Medical Education Building, Room 6243, New Orleans, LA, 70112, USA

    Jennifer E. Cameron

  2. Department of Medicine, Section of Infectious Diseases, 1542 Tulane Avenue, Box T4M-1, New Orleans, LA, USA

    Michael Hagensee

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  1. Penn State Cancer Institute, Penn State University, Hershey, PA, USA

    Craig Meyers

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Table 6.1 List of abbreviations used in this chapter
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Cameron, J.E., Hagensee, M. (2019). HPV-Associated Oropharyngeal Cancer in the HIV/AIDS Patient. In: Meyers, C. (eds) HIV/AIDS-Associated Viral Oncogenesis. Cancer Treatment and Research, vol 177. Springer, Cham. https://doi.org/10.1007/978-3-030-03502-0_6

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