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Surgery for Malignant Tumors of the Minor Salivary Glands

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Salivary Gland Cancer

Abstract

Malignant tumors of minor salivary glands (MiSGMTs) are rare, the majority of them being located in the oral cavity and oropharynx. Adenoid cystic carcinoma (AdCC) is the most frequently encountered histologic type followed by mucoepidermoid carcinoma (MEC); however, many other malignant salivary tumor types have also been described. Presenting complaints of MiSGMT depend on the anatomic site of origin. A painless submucosal swelling is the most frequent finding, possibly associated with obstructive symptoms when the tumor is located in the sinonasal cavities, pharynx, larynx, or trachea; pain or nerve impairment may also be reported.

Indications and treatment strategies in MiSGMT do not significantly differ from those of other epithelial malignancies, with the exception of AdCC, that has peculiar biological features. Surgery followed by adjuvant radiotherapy is considered the mainstay of treatment for most of MiSGMTs. The goal of surgery is to achieve radical resection with clear margins: however, there are specific problems, related to histology and site of origin, to be considered when planning intervention. Once the tumor is staged and graded, adjuvant radiotherapy is recommended for most patients. In view of peculiarities of the different subsites in terms of surgical technique and requirements, a separate discussion will be provided. Furthermore, all the main pathways of spread typically involved in AdCC will be reviewed.

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Authors and Affiliations

  1. Department of Otorhinolaryngology – Head and Neck Surgery, University of Brescia, Brescia, Italy

    Davide Lombardi, Davide Lancini, Vittorio Rampinelli & Piero Nicolai

  2. Department of Otorhinolaryngology, General Hospital of Bolzano, Bolzano, Italy

    Remo Accorona

  3. Section of Pathology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

    Anna Bozzola

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  1. Davide Lombardi
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  2. Remo Accorona
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Correspondence to Davide Lombardi .

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Editors and Affiliations

  1. Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Milan, Italy

    Lisa Licitra

  2. Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Milan, Italy

    Laura D. Locati

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Lombardi, D., Accorona, R., Lancini, D., Rampinelli, V., Bozzola, A., Nicolai, P. (2019). Surgery for Malignant Tumors of the Minor Salivary Glands. In: Licitra, L., Locati, L. (eds) Salivary Gland Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-02958-6_7

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  • DOI: https://doi.org/10.1007/978-3-030-02958-6_7

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-030-02958-6

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