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Cellular Cardiomyoplasty: Its Past, Present, and Future

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Cellular Cardiomyoplasty

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1036))

Abstract

Cellular cardiomyoplasty is a cell therapy using stem cells or progenitor cells for myocardial regeneration to improve cardiac function and mitigate heart failure. Since we first published cellular cardiomyoplasty in 1989, this procedure became the innovative method to treat damaged myocardium other than heart transplantation. A significant improvement in cardiac function, metabolism, and perfusion is generally observed in experimental and clinical studies, but the improvement is mild and incomplete. Although safety, feasibility, and efficacy have been well documented for the procedure, the beneficial mechanisms remain unclear and optimization of the procedure requires further study. This chapter briefly reviews the stem cells used for cellular cardiomyoplasty and their clinical outcomes with possible improvements in future studies.

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Authors and Affiliations

  1. Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA

    Elizabeth K. Lamb, Grace W. Kao & Race L. Kao

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  1. Elizabeth K. Lamb
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  2. Grace W. Kao
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  1. , Department of Surgery, East Tennessee State University, Johnson City, 37614, Tennessee, USA

    Race L. Kao

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Lamb, E.K., Kao, G.W., Kao, R.L. (2013). Cellular Cardiomyoplasty: Its Past, Present, and Future. In: Kao, R. (eds) Cellular Cardiomyoplasty. Methods in Molecular Biology, vol 1036. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-511-8_1

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  • DOI: https://doi.org/10.1007/978-1-62703-511-8_1

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