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Emerging Trends in Cell and Gene Therapy pp 347–371Cite as

Pluripotent Stem Cells for Neural Regeneration

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Abstract

Neurodegenerative disorders remain challenging to treat using traditional pharmacological or neurosurgical approaches. In contrast, cell therapy is a promising strategy for ameliorating irreparable brain tissue damage during the process of neurogenesis. Currently, more efficient methodologies for isolating neural stem cells from a plethora of sources including hematopoietic stem cells and mesenchymal stem cells are continually being developed. The availability of neural stem cells would ensure that damaged neural tissues can be regenerated and fast-track translation from bed to bedside. In this chapter, we discuss various sources of neural stem cells, strategies for their isolation and characterization, and application of stem cells in the treatment of neurological disorders. Historically, clinical application of cell therapy for treating neurological diseases has been hindered due to numerous technical difficulties. Therefore, these barriers and potential ways of addressing them are also discussed.

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Authors and Affiliations

  1. PAN Research Foundation, Hyderabad, AP, India

    Syed Ameer Basha Paspala & Sandeep Vishwakarma

  2. Department of Neurology, CARE, The Institute of Medical Sciences, Hyderabad, AP, India

    Syed Ameer Basha Paspala

  3. Habeebullah’s Memorial Centre for Stem Cell Sciences, Centre for Liver Research and Diagnostics, Hyderabad, AP, India

    Aleem Ahmed Khan & T. V. Ramakrishna Murthy

  4. Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, AP, India

    Sandeep Vishwakarma

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  1. Syed Ameer Basha Paspala
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  4. T. V. Ramakrishna Murthy
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Correspondence to Syed Ameer Basha Paspala .

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  1. Pharmaceutical Sciences, Douglas Hall 206, Chicago State University, S. King Drive 9501, Chicago, 60628, Illinois, USA

    Michael K. Danquah

  2. Health Science Center, Dept. Pharmaceutical &, University of Tennessee, S. Manassas 19, Memphis, 38103, Tennessee, USA

    Ram I. Mahato

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Paspala, S.A.B., Khan, A.A., Vishwakarma, S., Murthy, T.V.R. (2013). Pluripotent Stem Cells for Neural Regeneration. In: Danquah, M., Mahato, R. (eds) Emerging Trends in Cell and Gene Therapy. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-417-3_16

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