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Molecular Modelling of Odorant/Olfactory Receptor Complexes

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Olfactory Receptors

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1003))

Abstract

Providing a rationale that associates a chemical structure of an odorant to its induced perception has been sought for a long time. To achieve this, a detailed atomic structure of both the odorant and the olfactory receptor must be known. State-of-the-art techniques to model the 3D structure of an olfactory receptor in complex with various odorants are presented here. These range from sequence alignment with known structures to molecular dynamics simulations in a realistic environment.

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Acknowledgments

The CINES is acknowledged for providing computer time for the project cmi1024.

Author information

Authors and Affiliations

  1. Institut de Chimie de Nice, UMR CNRS, Université de Nice Sophia Antipolis, Nice, France

    Landry Charlier, Jérémie Topin, Claire A. de March & Jerome Golebiowski

  2. Division of Research, Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA

    Peter C. Lai & Chiquito J. Crasto

Authors
  1. Landry Charlier
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  2. Jérémie Topin
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  3. Claire A. de March
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  4. Peter C. Lai
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  5. Chiquito J. Crasto
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  6. Jerome Golebiowski
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Editor information

Editors and Affiliations

  1. , Department of Genetics, University of Alabama, Birmingham, 20th Street South 720, Birmingham, 35294, Alabama, USA

    Chiquito J. Crasto

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Charlier, L., Topin, J., de March, C.A., Lai, P.C., Crasto, C.J., Golebiowski, J. (2013). Molecular Modelling of Odorant/Olfactory Receptor Complexes. In: Crasto, C. (eds) Olfactory Receptors. Methods in Molecular Biology, vol 1003. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-377-0_4

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  • DOI: https://doi.org/10.1007/978-1-62703-377-0_4

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-376-3

  • Online ISBN: 978-1-62703-377-0

  • eBook Packages: Springer Protocols

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