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Hematological Malignancies

  • Book
  • © 2013

Overview

Editors:
  1. Magdalena Czader

    1. School of Medicine, Dept. Pathology & Laboratory Medicine, Indiana University, Indianapolis, USA

    View editor publications

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  • Features tips on trouble shooting and avoiding known pitfalls
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 999)

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About this book

Increased knowledge on the pathogenesis of hematologic diseases has been translated into diagnostic and prognostic applications.   Hematopathology and laboratory hematology were among the first disciplines to embrace molecular diagnostics.  Hematological Malignancies:Methods and Protocols, explores molecular-based assays frequently used in the routine diagnostic hematopathology and laboratory hematology.  Many of these protocols were initially developed as research applications and were further refined as they transitioned to the diagnostic laboratory. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

 Authoritative and practical, Hematological Malignancies: Methods and Protocols aids scientist in the continuing study of tests essential for contemporary laboratory diagnostics of hematological neoplasms.

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Table of contents (21 protocols)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Quantitative BCR-ABL1 RQ-PCR Fusion Transcript Monitoring in Chronic Myelogenous Leukemia

    • Franklin R. Moore, Carole B. Rempfer, Richard D. Press
    Pages 1-23

  3. Detection of BCR-ABL1 Kinase Domain Mutations Causing Imatinib Resistance in Chronic Myelogenous Leukemia

    • Franklin R. Moore, Fei Yang, Richard D. Press
    Pages 25-39

  4. Laboratory Detection of JAK2 V617F in Human Myeloproliferative Neoplasms

    • Jonathan S. Kui, Rosanny Espinal-Witter, Y. Lynn Wang
    Pages 41-57

  5. c-kit Mutational Analysis in Paraffin Material

    • Karl Sotlar
    Pages 59-78

  6. Detection of Recurrent Cytogenetic Abnormalities in Acute Lymphoblastic and Myeloid Leukemias Using Fluorescence In Situ Hybridization

    • Gail H. Vance
    Pages 79-91

  7. Liquid Bead Array Technology in the Detection of Common Translocations in Acute and Chronic Leukemias

    • Rodney E. Shackelford, Keith D. Jackson, Michael J. Hafez, Christopher D. Gocke
    Pages 93-103

  8. Molecular Genetic Tests for FLT3, NPM1, and CEBPA in Acute Myeloid Leukemia

    • Qing Zhang, Shaochun Bai, Gail H. Vance
    Pages 105-121

  9. Flow Cytometric Monitoring of Residual Disease in Acute Leukemia

    • Brent L. Wood
    Pages 123-136

  10. Chimerism Analysis Following Hematopoietic Stem Cell Transplantation

    • Kathleen M. Murphy
    Pages 137-149

  11. Detection of Clonal Immunoglobulin Heavy Chain Gene Rearrangements by the Polymerase Chain Reaction and Capillary Gel Electrophoresis

    • Hongxin Fan, Ryan S. Robetorye
    Pages 151-167

  12. Detection of Clonal T-Cell Receptor Beta and Gamma Chain Gene Rearrangement by Polymerase Chain Reaction and Capillary Gel Electrophoresis

    • Hongxin Fan, Ryan S. Robetorye
    Pages 169-188

  13. Detection of Genetic Translocations in Lymphoma Using Fluorescence In Situ Hybridization

    • Kaaren K. Reichard, Sheldon Robinett
    Pages 189-202

  14. Molecular Detection of t(14;18)(q32;q21) in Follicular Lymphoma

    • C. Cameron Yin, Rajyalakshmi Luthra
    Pages 203-209

  15. Molecular Detection of t(11;14)(q13;q32) in Mantle Cell Lymphoma

    • C. Cameron Yin, Rajyalakshmi Luthra
    Pages 211-216

  16. Detection of t(2;5)(p23;q35) in Anaplastic Large-Cell Lymphoma by Long-Range Nested Polymerase Chain Reaction Assay

    • C. Cameron Yin, Rajyalakshmi Luthra
    Pages 217-222

  17. EBER In Situ Hybridization for Epstein–Barr Virus

    • Lawrence M. Weiss, Yuan-Yuan Chen
    Pages 223-230

  18. Epstein–Barr Virus (EBV) Load Determination Using Real-Time Quantitative Polymerase Chain Reaction

    • Hongxin Fan, Ryan S. Robetorye
    Pages 231-243

  19. Molecular and Immunohistochemical Detection of Kaposi Sarcoma Herpesvirus/Human Herpesvirus-8

    • Amy Chadburn, Janet Wilson, Y. Lynn Wang
    Pages 245-256

  20. Detection of Cytomegalovirus Infection by Quantitative Polymerase Chain Reaction

    • Magdalena Czader, Kristin Post, Liang Cheng
    Pages 257-271
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Editors and Affiliations

  • School of Medicine, Dept. Pathology & Laboratory Medicine, Indiana University, Indianapolis, USA

    Magdalena Czader

Bibliographic Information

  • Book Title: Hematological Malignancies

  • Editors: Magdalena Czader

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-62703-357-2

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, New York 2013

  • Hardcover ISBN: 978-1-62703-356-5Published: 11 May 2013

  • Softcover ISBN: 978-1-4939-5726-2Published: 23 August 2016

  • eBook ISBN: 978-1-62703-357-2Published: 13 May 2013

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: X, 304

  • Number of Illustrations: 15 b/w illustrations, 32 illustrations in colour

  • Topics: Molecular Medicine, Hematology

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