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Brain Innate Immune System and Its Modulation by Diet: The Role of Polyunsaturated Fatty Acids

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Dietary Components and Immune Function

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Key Points

The innate immune system of the brain is composed of microglial cells and astrocytes, which, once activated, produce proinflammatory cytokines. Proinflammatory cytokines act in the brain through specific receptors produced by brain cells and trigger behavioral modifications (sickness behavior) and cognitive and mood disorders. Aging-related neuroinflammatory processes are involved in neurodegenerative diseases. Polyunsaturated fatty acids (PUFAs) are essential nutrients provided by the diet that strongly regulate neuroinflammation and associated behavioral changes.

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Supported by INRA and Conseil Général d’Aquitaine.

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  1. Psychoneuroimmunology, Nutrition and Genetic (PsyNuGen), INRA 1286, CNRS, 5226, Université Bordeaux 2, 146 Rue Leo Saignat, Bordeaux Cedex, 33076, France

    Sophie Layé PHD & Anais Duffaud PHD

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  1. Sophie Layé PHD
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  2. Anais Duffaud PHD
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Correspondence to Sophie Layé PHD .

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  1. Health Sciences Center, Department of Health Promotion Sciences, University of Arizona, 1295 N. Martin Ave. 1295, Tucson, 85724-5155, USA

    Ronald Ross Watson

  2. Mel & Enid Zuckerman College of, Public Health, University of Arizona, Tucson, 85724-5163, USA

    Sherma Zibadi

  3. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

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Layé, S., Duffaud, A. (2010). Brain Innate Immune System and Its Modulation by Diet: The Role of Polyunsaturated Fatty Acids. In: Watson, R., Zibadi, S., Preedy, V. (eds) Dietary Components and Immune Function. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-061-8_11

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