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Signaling Networks in Mesenchymal Stem Cells

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Regulatory Networks in Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Mechanisms governing the differentiation of mesenchymal stem cells (MSC) are poorly understood. Functional network analysis based on gene expression data is a powerful tool to study signaling mechanisms in cells. Such studies have yielded useful information in other stem cell systems like embryonic and hematopoietic stem cells. Studies dealing with single pathways or genes active in MSC form the building blocks for network analyses of MSC. This chapter describes how functional network analysis is useful in identifying signaling pathways that are active in MSC and how a core MSC network identifies known MSC pathways while predicting new pathways that are important in MSC differentiation.

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Author information

Authors and Affiliations

  1. Genome & Gene Expression Data Analysis Group, Bioinformatics Institute, A* STAR Singapore, 30 Biopolis St., 138671, Matrix #07-01, Singapore

    Vivek M. Tanavde

  2. Biomolecular Function Discovery Group, Bioinformatics Institute, Singapore

    Lailing Liew

  3. Genome & Gene Expression Data Analysis Group, Bioinformatics Institute, Singapore

    Jiahao Lim & Felicia Ng

Authors
  1. Vivek M. Tanavde
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  2. Lailing Liew
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  3. Jiahao Lim
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  4. Felicia Ng
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Corresponding author

Correspondence to Vivek M. Tanavde .

Editor information

Editors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Vinagolu K. Rajasekhar MSc, MPhil, PhD

  2. Invitrogen Corporation, Frederick, MD, USA

    Mohan C. Vemuri Ph.D.

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC, a part of Springer Science+Business Media, LLC

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Tanavde, V.M., Liew, L., Lim, J., Ng, F. (2009). Signaling Networks in Mesenchymal Stem Cells. In: Rajasekhar, V.K., Vemuri, M.C. (eds) Regulatory Networks in Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-60327-227-8_28

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