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Peptide-Based Drug Design

  • Book
  • © 2008

Overview

Editors:
  1. Laszlo Otvos

    1. Center for Biotechnology, Temple University, Philadelphia

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  • Presents full coverage of peptide-based drug development arranged in a sequential order as the leads proceed through the preclinical pipeline
  • Describes innovative and unusual technologies
  • Special focus on peptide drugs in infectious diseases
  • Includes contributions from international leaders in their respective fields
  • Provides a balance of scientific rigor, potential reproducibility and drug development economics

Part of the book series: Methods in Molecular Biology (MIMB, volume 494)

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About this book

Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular Biology™ series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls.

Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.

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Table of contents (16 protocols)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Peptide-Based Drug Design: Here and Now

    • Laszlo Otvos Jr.
    Pages 1-8

  3. Strategies for the Discovery, Isolation, and Characterization of Natural Bioactive Peptides from the Immune System of Invertebrates

    • Philippe Bulet
    Pages 9-29

  4. Sequence Analysis of Antimicrobial Peptides by Tandem Mass Spectrometry

    • Christin Stegemann, Ralf Hoffmann
    Pages 31-46

  5. The Spot Technique: Synthesis and Screening of Peptide Macroarrays on Cellulose Membranes

    • Dirk F.H. Winkler, William D. Campbell
    Pages 47-70

  6. Analysis of Aβ Interactions Using ProteinChip Technology

    • Eleni Giannakis, Lin-Wai Hung, Keyla Perez Camacaro, David P. Smith, Kevin J. Barnham, John D. Wade
    Pages 71-86

  7. NMR in Peptide Drug Development

    • Jan-Christoph Westermann, David J. Craik
    Pages 87-113

  8. Molecular Dynamics Simulations of Peptides

    • Jeffrey Copps, Richard F. Murphy, Sandor Lovas
    Pages 115-126

  9. Short Linear Cationic Antimicrobial Peptides: Screening, Optimizing, and Prediction

    • Kai Hilpert, Christopher D. Fjell, Artem Cherkasov
    Pages 127-159

  10. Investigating the Mode of Action of Proline-Rich Antimicrobial Peptides Using a Genetic Approach: A Tool to Identify New Bacterial Targets Amenable to the Design of Novel Antibiotics

    • Marco Scocchi, Maura Mattiuzzo, Monica Benincasa, Nikolinka Antcheva, Alessandro Tossi, Renato Gennaro
    Pages 161-176

  11. Serum Stability of Peptides

    • Håvard Jenssen, Stein Ivar Aspmo
    Pages 177-186

  12. Preparation of Glycosylated Amino Acids Suitable for Fmoc Solid-Phase Assembly

    • Mare Cudic, Gayle D. Burstein
    Pages 187-208

  13. Synthesis of O-Phosphopeptides on Solid Phase

    • David Singer, Ralf Hoffmann
    Pages 209-222

  14. Peptidomimetics: Fmoc Solid-Phase Pseudopeptide Synthesis

    • Predrag Cudic, Maciej Stawikowski
    Pages 223-246

  15. Synthesis of Toll-Like Receptor-2 Targeting Lipopeptides as Self-Adjuvanting Vaccines

    • Brendon Y. Chua, Weiguang Zeng, David C. Jackson
    Pages 247-261

  16. Synthesis of a Multivalent, Multiepitope Vaccine Construct

    • Laszlo Otvos Jr
    Pages 263-273

  17. Cysteine-Containing Fusion Tag for Site-Specific Conjugation of Therapeutic and Imaging Agents to Targeting Proteins

    • Marina V. Backer, Zoia Levashova, Richard Levenson, Francis G. Blankenberg, Joseph M. Backer
    Pages 275-294

  18. Back Matter

    Pages 295-303
    Download chapter PDF
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Editors and Affiliations

  • Center for Biotechnology, Temple University, Philadelphia

    Laszlo Otvos

Bibliographic Information

  • Book Title: Peptide-Based Drug Design

  • Editors: Laszlo Otvos

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-59745-419-3

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-58829-990-1Published: 09 October 2008

  • Softcover ISBN: 978-1-61737-869-0Published: 19 November 2010

  • eBook ISBN: 978-1-59745-419-3Published: 26 August 2008

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 303

  • Topics: Pharmacology/Toxicology, Medicinal Chemistry

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