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Obesity and Diabetes pp 39–67Cite as

Genetics of Obesity and Diabetes

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Part of the book series: Contemporary Diabetes ((CDI))

Abstract

Obesity and diabetes mellitus are two disease states with significant morbidity and mortality, the prevalence of which is reaching the point of an international epidemic, with continuously increasing numbers of affected individuals (1). Full elucidation of the pathogenesis of obesity and diabetes mellitus and, thus, the development of preventative and therapeutic approaches require delineation of the genetic defects associated with these disease states and clarification of the molecular mechanisms that lead from genotype to phenotype. This chapter focuses on recent advances in the field and, by presenting data from several large-scale human studies and a wide range of animal models, outlines researchers’ current knowledge on the genetics of obesity and diabetes (with an emphasis on type 2 diabetes). A good understanding of the mutations and molecular pathways involved in the development of disease could allow presymptomatic diagnosis and more accurate prognosis and could eventually reveal better therapeutic targets.

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Authors and Affiliations

  1. Department of Genetics, Children’s Hospital, Harvard Medical School, Boston, MA

    Despina Sanoudou PhD, FACMG, Cbiol, MIbiol

  2. Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Christos S. Mantzoros MD, DSc (Division of Endocrinology)

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  1. Despina Sanoudou PhD, FACMG, Cbiol, MIbiol
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  1. Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Christos S. Mantzoros MD, DSc

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Sanoudou, D., Mantzoros, C.S. (2006). Genetics of Obesity and Diabetes. In: Mantzoros, C.S. (eds) Obesity and Diabetes. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-59259-985-1_3

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