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Epilepsy and the Ketogenic Diet pp 185–199Cite as

The Ketogenic Diet

Interactions With Brain Amino Acid Handling

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Part of the book series: Nutrition and Health ((NH))

Abstract

The energy requirements of the human brain are enormous. Cerebral oxygen consumption is 35 mL/min/kg or approx 50 mL/min in the adult brain. The rate of wholebody O2 consumption is 250 mL/min, indicating that approx 20% of oxygen utilization is directed toward the needs of the brain, which occupies only 2% of body weight. Virtually no oxygen is stored in the brain, implying that to maintain the integrity of this vital organ, cerebral blood flow (approx 800 mL/min), which constitutes about 15% of cardiac output, must proceed in an uninterrupted manner. If flow is completely shut down, a state of unconsciousness would ensue within 10s.

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Authors
  1. Marc Yudkoff
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  2. Yevgeny Daikhin
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  3. Ilana Nissim
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  4. Itzhak Nissim
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Editors and Affiliations

  1. Department of Neurology, University of Wisconsin, Madison, WI, USA

    Carl E. Stafstrom MD, PhD

  2. The Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USA

    Jong M. Rho MD

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Yudkoff, M., Daikhin, Y., Nissim, I., Nissim, I. (2004). The Ketogenic Diet. In: Stafstrom, C.E., Rho, J.M. (eds) Epilepsy and the Ketogenic Diet. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-808-3_15

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  • DOI: https://doi.org/10.1007/978-1-59259-808-3_15

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