Stem Cell Transplantation for Hematologic Malignancies

1. Front Matter

   Pages i-x

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2. Transplant for Malignant Disease

   1. Front Matter

      Pages 1-1

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   2. Allogeneic and Autologous Stem Cell Transplantation for Acute Leukemia and Myelodysplasia in the Adult

      • Sandra Cohen, Stephen J. Forman

      Pages 3-24

   3. Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia

      • Humberto Caldera, Sergio Giralt

      Pages 25-45

   4. Stem Cell Transplantation for Hodgkin’s and Non-Hodgkin’s Lymphomas

      • Thomas J. Kenney, John W. Sweetenham

      Pages 47-84

   5. Autologous and Allogeneic Transplantation for Multiple Myeloma

      • Faith E. Davies, Kenneth C. Anderson

      Pages 85-97

   6. Hematopoietic Progenitor Cell Transplantation for Breast Cancer

      • Yago Nieto, Elizabeth J. Shpall

      Pages 99-132

3. Complications of Transplantion

   1. Front Matter

      Pages 133-133

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   2. Pathophysiology of Acute Graft-vs-Host Disease

      • Takanori Teshima, James L. M. Ferrara

      Pages 135-157

   3. Acute Graft-vs-Host Disease

      • Uwe Platzbecker, H. Joachim Deeg

      Pages 159-184

   4. Chronic Graft-vs-Host Disease After Transplantation

      • Georgia B. Vogelsang, Colleen H. McDonough

      Pages 185-200

   5. Immune Reconstitution After Allogeneic Transplantation

      • Carolyn A. Keever-Taylor

      Pages 201-236

   6. Infection in the Hematopoietic Stem Cell Transplant Recipient

      • Lindsey Baden, Robert H. Rubin

      Pages 237-258

   7. EBV Lymphoproliferative Disease After Transplantation

      • Stephen Gottschalk, Cliona M. Rooney, Helen E. Heslop

      Pages 259-270

   8. Pathophysiology of Lung Injury After Hematopoietic Stem Cell Transplantation

      • Kenneth R. Cooke

      Pages 271-295

   9. Hepatic Veno-Occlusive Disease

      • Paul G. Richardson

      Pages 297-314

   10. Quality-of-Life Issues Posttransplantation

       • Stephanie J. Lee

       Pages 315-333

4. Sources of Donor Stem Cells

   1. Front Matter

      Pages 335-335

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   2. Stem Cell Sources

      • Corey Cutler, Joseph H. Antin

      Pages 337-356

   3. Allogeneic Unrelated Donor Blood and Marrow Transplantation

      • Daniel Weisdorf

      Pages 357-371

A comprehensive survey of the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation.

• blood
• bone marrow
• cell
• hematopoietic stem cell
• hematopoietic stem cell transplantation
• leukemia
• liver
• lymphocytes
• lymphoma
• stem cell
• stem cell transplantation
• stem cells
• transplantation
• tumor

"Current transplant approaches to the individual hematologic malignancies are discussed and the literature critiqued. The diverse complications of transplantation are discussed in considerable detail; the authors clearly define the underlying pathophysiology as well as state-of-the-art treatment approaches. Chapters on the new field of alternative graft sources is one of the book's best features and include unrelated, haploidentical and umbilical cord transplantation. This is a high-quality publication that is easy to read and not as overwhelming as the larger, more comprehensive transplant books. It is full of helpful information and references. "-Doody's Health Sciences Book Review Journal

"This book provides a timely update and a valuable summary of this rapidly evolving field." -Annals of Internal Medicine

"...a comprehensive review of the current state of the art in hematopoietic setm-cell transplantation for hematologic cancers and breast cancer...belongs in every facility that performs hematopoietic stem-cell transplantation." - New England Journal of Medicine

• Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA

  Robert J. Soiffer

Policies and ethics