Abstract
The cerebrum exerts control of voluntary somatic motor activity through several descending pathways. The direct pathway is via the pyramidal system, which includes the corticospinal (pyramidal) tract together with fibers that diverge from it to innervate cranial nerve motoneurons, the corticobulbar tract (see Fig. 24.1). The cortical neurons that form the tract are upper motoneurons. There are two other major descending pathways that arise from the cortex: the corticorubral/rubrospinal tract and the corticoreticular/reticulospinal tract, but these are less direct. They involve a synapse in the red nucleus and in the reticular formation of the lower brainstem, respectively. Before evolution of the cerebral cortex in mammals, voluntary somatic motor activity was mainly mediated by upper motoneurons in the red nucleus and the brainstem reticular formation.
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Aizman O, Brismar H, Uhlen P, et al. Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons. Nature Neurosci. 2000;3:226–230.
Bates G, Harper PS, Jones L. Huntington’s Disease. New York: Oxford University Press; 2002.
Brady AM, O’Donnell P. Dopaminergic modulation of prefrontal cortical input to nucleus accumbens neurons in vivo. J. Neurosci. 2004;24:1040–1049.
Gerfen CR. D1 dopamine receptor supersensitivity in the dopamine-depleted striatum animal model of Parkinson’s disease. Neuroscientist 2003;9:455–462.
Guzman JN, Hernandez A, Galarraga E, et al. Dopaminergic modulation of axon collaterals interconnecting spiny neurons of the rat striatum. J. Neurosci. 2003;23:8931–8940.
Haber SN, Fudge JL, McFarland NR. Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. J. Neurosci. 2000;20:2369–2382.
Kawaguchi Y. Neostriatal cell subtypes and their functional roles. Neurosci. Res. 1997;27:1–8.
Kelly RM, Strick PL. Macro-architecture of basal ganglia loops with the cerebral cortex: use of rabies virus to reveal multisynaptic circuits. Prog. Brain Res. 2004;143:449–459.
Luo J, Kaplitt MG, Fitzsimons HL, et al. Subthalamic GAD gene therapy in a Parkinson’s disease rat model. Science 2002;298:425–429.
Matsumura M, Kojima J. The role of the pedunculopontine tegmental nucleus in experimental parkinsonism in primates. Stereotact. Funct. Neurosurg. 2001;77:108–115.
Obeso JA. The Basal Ganglia and New Surgical Approaches for Parkinson’s Disease. Philadelphia, PA: Lippincott-Raven; 1997.
Obeso JA, Rodriguez-Oroz MC, Rodriguez M, Arbizu J, Gimenez-Amaya JM. The basal ganglia and disorders of movement: pathophysiological mechanisms. News Physiol. Sci. 2002;17:51–55.
Onn SP, West AR, Grace AA. Dopamine-mediated regulation of striatal neuronal and network interactions. Trends Neurosci. 2000;23:S48–S56.
Parent A, Levesque M, Parent M. A re-evaluation of the current model of the basal ganglia. Parkinsonism Relat Disord. 2001;7:193–198.
Plenz D. When inhibition goes incognito: feedback interaction between spiny projection neurons in striatal function. Trends Neurosci. 2003;26:436–443.
Reynolds JN, Wickens JR. Dopamine-dependent plasticity of corticostriatal synapses. Neural Netw. 2002;15:507–521.
Rodriguez-Oroz MC, Rodriguez M, Guridi J, et al. The subthalamic nucleus in Parkinson’s disease: somatotopic organization and physiological characteristics. Brain 2001;124:1777–1790.
Steiner H, Gerfen CR. Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior. Exp. Brain Res. 1998;123:60–76.
Tunstall MJ, Oorschot DE, Kean A, Wickens JR. Inhibitory interactions between spiny projection neurons in the rat striatum. J. Neurophysiol. 2002;88:1263–1269.
West AR, Floresco SB, Charara A, Rosenkranz JA, Grace AA. Electrophysiological interactions between striatal glutamatergic and dopaminergic systems. Ann. NY Acad. Sci. 2003;1003:53–74.
Wichmann T, DeLong MR. Functional neuroanatomy of the basal ganglia in Parkinson’s disease. Adv. Neurol. 2003;91:9–18.
Wise SP, Murray EA, Gerfen CR. The frontal cortex-basal ganglia system in primates. Crit. Rev. Neurobiol. 1996;10:317–356.
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(2005). Basal Ganglia and Extrapyramidal System. In: The Human Nervous System. Humana Press. https://doi.org/10.1007/978-1-59259-730-7_24
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DOI: https://doi.org/10.1007/978-1-59259-730-7_24
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