Lupus

1. Front Matter

   Pages i-xx

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2. Lupus

   • Evelyn V. Hess

   Pages 1-12

3. The Vascular Endothelium

   • Bruce N. Cronstein, Allison Reiss, Sandeep Malhotra

   Pages 13-20

4. Nitric Oxide in Systemic Lupus Erythematosus

   • H. Michael Belmont, Ashok R. Amin, Steven B. Abramson

   Pages 21-42

5. Molecular Mimicry, Altered Apoptosis, and Immunomodulation as Mechanisms of Viral Pathogenesis in Systemic Lupus Erythematosus

   • Andras Perl, Katalin Banki

   Pages 43-64

6. Clustering and Proteolytic Cleavage of Autoantigens in Surface Blebs of Apoptotic Cells

   • Antony Rosen, Livia Casciola-Rosen

   Pages 65-78

7. Immune Effects of Bacterial DNA and Their Possible Role in the Pathogenesis of Lupus

   • Rebecca S. Tuetken, Ae-Kyung Yi, Arthur M. Krieg

   Pages 79-100

8. Genetics of Systemic Lupus Erythematosus

   • Pércio S. Gulko, Robert J. Winchester

   Pages 101-123

9. Genetic Insights into Murine Lupus

   • Chandra Mohan, Laurence Morel, Edward K. Wakeland

   Pages 124-139

10. Murine Graft-vs-Host Disease

    • Andrei Shustov, Violetta Rus, Phuong Nguyen, Charles S. Via

    Pages 140-151

11. Lessons from Knockout and Transgenic Lupus-Prone Mice

    • Stanford L. Peng, Joe Craft

    Pages 152-166

12. B Cells in Systemic Lupus Erythematosus

    • Stamatis-Nick C. Liossis, George C. Tsokos

    Pages 167-180

13. Mechanisms of the Pathogenic Autoimmune Response in Lupus

    • Syamal K. Datta

    Pages 181-201

14. T Cell Autoimmunity in Lupus

    • Mark J. Mamula

    Pages 202-219

15. T-, B-, and Natural Killer Cell Dysfunction in Murine Systemic Lupus Erythematosus Models

    • Philip L. Cohen

    Pages 220-230

16. Mechanisms of T-Helper Cell Activation and Function in Systemic Lupus Erythematosus

    • Mary K. Crow

    Pages 231-256

17. A Genetic Mechanism Underlying Deficient Type I Protein Kinase A Activity in Systemic Lupus Erythematosus T Lymphocytes

    • Islam U. Khan, Dama Laxminarayana, Gary M. Kammer

    Pages 257-277

18. Impaired DNA Methylation in Lupus T Cells

    • Jeannine M. Scott, Bruce C. Richardson

    Pages 278-298

19. Impaired Non-Antigen-Specific T-Cell Cytolytic Activity in SLE

    • William Stohl

    Pages 299-311

20. Natural Killer Cells and CD8+ T Cells in the Downregulation of Antibody Production in Healthy Subjects and SLE

    • David A. Horwitz, J. Dixon Gray, Katzuo Ohtsuka, Bricia Toro, Mary M. Stimmler, Lillie Hsu

    Pages 312-320

Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.

• Antigen
• apoptosis
• autoimmunity
• bacteria
• cytokine
• genetics
• inflammation
• lymphocytes
• macrophages
• pathogenesis
• pathophysiology
• physiology
• therapy
• thrombosis

"This effort represents a comprehensive and authoritative coverage of work on lupus. It is up to date in that the latest developments in the field are provided (e.g., the role of Fas and apoptosis in disease management). All workers in this area will find this a valuable resource. It also represents a worthwhile addition to medical libraries..." -4 Stars, Doody's Health Sciences Book Review Journal

"Firstly, the references quoted in the various chapters are well poised, with a mix of historical ones and very recent ones. Secondly, the authors were asked to keep in mind four issues while writing: their working hypothesis, the relationship between the hypothesis and the advancement of understanding of lupus pathogenesis, how novel information allows new insights in the field and where to direct research in the next 5 years...I strongly recommend reading this book. It has the major merit of presenting in a coordinated fashion many new findings on a disease that remains largely mysterious. This book has the potential to encourage cross-fertilization among researchers interested in the field of autoimmunity, and provides a valuable tool for newcomers to get a sense of the daunting problems that remain to be solved in order to better understand the regulation and dysregulation of the immune system." -Journal of Investigative Dermatology

• Section on Rheumatology, Department of Internal Medicine, The Wake Forest University School of Medicine, Winston-Salem, USA

  Gary M. Kammer

• Division of Rheumatology and Immunology, Uniformed Services University of Health Sciences, Bethesda, USA

  George C. Tsokos

• Department of Clinical Physiology, Walter Reed Army Institute of Research, USA

  George C. Tsokos

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