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Insulin-Like Growth Factor Binding Proteins in Endocrine-Related Neoplasia

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Book cover Endocrine Oncology

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

The insulin-like growth factor binding proteins (IGFBPs) are components of the IGF signaling system, which is comprised additionally of the IGF-I, IGF-II, and insulin ligands, and a family of transmembrane receptors, including the insulin receptor (IR) and IGF-I and IGF-II receptors (IGF-IR and IGF-IIR) (1–3). Six IGFBPs have been identified, cloned, and sequenced (3–5). They share a high degree of similarity in their primary protein structure, particularly in their N- and C-terminal regions, which are separated by a variable midprotein segment of 55–95 amino acid residues (5). IGFBPs bind IGF-I and IGF-II, but not insulin, with high affinity (6), and are essential to transport IGFs, to prolong their half-lives, and to regulate the availability of free IGFs for interaction with IGFRs, thereby modulating the effects of IGFs on growth and differentiation (6–10). Recent evidence indicates that some IGFBPs may themselves have direct receptor-mediated effects, independent of IGFs. A growing body of data has demonstrated that IGFBP-3 is an important growth-suppressing factor in various cell systems, through an IGF-independent mechanism (11,12). In addition, the recent identification of proteins with significant similarity to IGFBPs in their N-terminal domains suggests the existence of other potential IGFBPs (13). This has led to the concept of an IGFBP superfamily with high- and low-affinity members, capable of influencing cell growth and differentiation by both IGF-dependent and IGF-independent means (Fig. 1, 13–15).

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Authors
  1. Giuseppe Minniti MD
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  2. Youngman Oh PhD
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  1. Department of Radiation Oncology, University of Michigan Cancer Center, Ann Arbor, MI, USA

    Stephen P. Ethier PhD

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Minniti, G., Oh, Y. (2000). Insulin-Like Growth Factor Binding Proteins in Endocrine-Related Neoplasia. In: Ethier, S.P. (eds) Endocrine Oncology. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-223-4_11

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  • DOI: https://doi.org/10.1007/978-1-59259-223-4_11

  • Publisher Name: Humana Press, Totowa, NJ

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