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Nuclear Receptors pp 1–5Cite as

Nuclear Receptors: A Historical Perspective

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1966))

Abstract

In this chapter, we summarize the birth of the field of nuclear receptors. These receptors exhibit a multitude of roles in cell biology and hence have attracted a great deal of interest in the drug discovery field. It is not certain whether these receptors evolved independently or an ancestral protein acquired various functions upon binding to preexisting small molecules, ligands. Currently, members of this receptor superfamily are categorized in six groups, including “orphan receptors.” Research in the area has resulted in several clinically used drugs and continues to reveal further previously unknown roles for these receptors paving the road toward more valuable discoveries in the future.

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Abbreviations

CAR:

Constitutive androstane receptor

COUP-TFII:

COUP transcription factor II receptor

ERRs:

Estrogen-related receptors

GCNF1:

The germ cell nuclear factor-1

HNF-4:

Hepatocyte nuclear factor-4 receptor

LXRs:

Liver X receptors

NGFI-B, NURR1, and NOR1:

The nerve growth factor induced clone B group of orphan receptors

NR5A1:

The steroidogenic factor 1

PPARs:

Peroxisome proliferator-activated receptors

PXR:

Pregnane X receptor

RARs:

Retinoic acid receptor

Rev-Erb, ROR:

Receptor tyrosine kinase-like orphan receptors

RXRs:

Retinoid X receptor

TRs:

Thyroid hormone receptor

VDR:

Vitamin D receptor

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Acknowledgments

The authors acknowledge the financial support of the following agencies: M.D.G. from ANPCyT (PICT 2016-0545), UBACYT, and Instituto Nacional del Cáncer; G.I.M. from ANPCyT (PICT 2016-2607). M.B.C., J.C.S, and O.B.S. are partially supported by the Research Centers in Minority Institutions (RCMI) program, grant 2G12MD007592 to the Border Biomedical Research Center (BBRC) at UTEP, from the National Institutes on Minority Health and Health Disparities (NIMHD), a component of the NIH. M.B.C. is also supported by the Department of Defense (DOD) Prostate Cancer Research Program (PCRP) through grant number W81XWH-17-1-0435.

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Authors and Affiliations

  1. Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

    Gisela I. Mazaira & Mario D. Galigniana

  2. Instituto de Biología y Medicina Experimental-CONICET, Buenos Aires, Argentina

    Nadia R. Zgajnar, Cecilia M. Lotufo, Cristina Daneri-Becerra & Mario D. Galigniana

  3. Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX, USA

    Jeffrey C. Sivils, Olga B. Soto & Marc B. Cox

Authors
  1. Gisela I. Mazaira
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  2. Nadia R. Zgajnar
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  3. Cecilia M. Lotufo
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  4. Cristina Daneri-Becerra
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  5. Jeffrey C. Sivils
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  6. Olga B. Soto
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  7. Marc B. Cox
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  8. Mario D. Galigniana
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Corresponding author

Correspondence to Mario D. Galigniana .

Editor information

Editors and Affiliations

  1. School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA

    Mostafa Z. Badr

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Mazaira, G.I. et al. (2019). Nuclear Receptors: A Historical Perspective. In: Badr, M. (eds) Nuclear Receptors. Methods in Molecular Biology, vol 1966. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9195-2_1

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  • DOI: https://doi.org/10.1007/978-1-4939-9195-2_1

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9194-5

  • Online ISBN: 978-1-4939-9195-2

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