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A Brief History of the β-Arrestins

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Beta-Arrestins

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1957))

Abstract

Arrestins have now been implicated in the actions of virtually every G protein-coupled receptor (GPCR) for which they have been examined. Originally discovered for their role in the turnoff of visual perception, their newly discovered pleotropic functions in the cellular and physiological actions of GPCRs not only illuminate new mechanisms of signal transduction but also offer new avenues for therapeutic utility. Below, in this introductory chapter, we provide a short historical description and synopsis of how arrestins conceptually became associated with the function of GPCRs.

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Acknowledgments

Work in the Caron/Barak group at Duke University has been supported by grants for the United States National Institutes of Health (5R37-MH073853, 5P30-DA029925, 4U19-MH082441, 1R33CA191198); a gift from the Pall Family Foundation and the Howard Hughes Medical Institutes (1992-2005).

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Authors and Affiliations

  1. Department of Cell Biology, Duke University Medical Center, Durham, NC, USA

    Marc G. Caron & Lawrence S. Barak

  2. Department of Neurobiology, Duke University Medical Center, Durham, NC, USA

    Marc G. Caron

  3. Department of Medicine, Duke University Medical Center, Durham, NC, USA

    Marc G. Caron

Authors
  1. Marc G. Caron
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  2. Lawrence S. Barak
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Corresponding authors

Correspondence to Marc G. Caron or Lawrence S. Barak .

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Editors and Affiliations

  1. Institut Cochin, INSERM U1016, Paris, France

    Mark G. H. Scott

  2. Department of Medicine, Research Institute of the McGill, University Health Center (RI-MUHC), McGill University, Montreal, QC, Canada

    Stéphane A. Laporte

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Caron, M.G., Barak, L.S. (2019). A Brief History of the β-Arrestins. In: Scott, M., Laporte, S. (eds) Beta-Arrestins. Methods in Molecular Biology, vol 1957. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9158-7_1

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  • DOI: https://doi.org/10.1007/978-1-4939-9158-7_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-9157-0

  • Online ISBN: 978-1-4939-9158-7

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