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Analysis of Illicit Drugs in Wastewater Using High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (HPLC-ESI-MS/MS)

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Analysis of Drugs of Abuse

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1810))

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Abstract

Consumption of illicit drugs is considered to be a global socioeconomic burden of adverse ecological and public health. Proper identification and quantification of trace level residues of illicit drugs in wastewater allow for an estimation of drug usage in a community, the amount of drug discharge into the environment, and the overall fate of drugs in the environment. This chapter provides a procedural detail of the determination of select illicit drugs and their metabolites in wastewater, suspended particulate matter, and sewage sludge using high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.

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References

  1. CARA (Comprehensive Addiction and Recovery Act) (2016) https://www.congress.gov/bill/114th-congress/senate-bill/524/text. Accessed on 22 March 2017

  2. Subedi B, Loganathan B (2016) Environmental emission of pharmaceuticals from wastewater treatment plants in the U.S.A. In Persistent organic Chemicals in the Environment: status and trends in the Pacific Basin Countries II temporal trends, ACS symposium series. American Chemical Society, Washington, DC, pp 181–202

    Google Scholar 

  3. Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect 107:907–938

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Subedi B, Kannan K (2014) Mass loading and removal of select illicit drugs in two wastewater treatment plants in New York State and estimation of illicit drug usage in communities through wastewater analysis. Environ Sci Technol 48:6661–6670

    Article  CAS  PubMed  Google Scholar 

  5. Baker DR, Kasprzyk-Hordern B (2011) Multi-residue analysis of drugs of abuse in wastewater and surface water by solid-phase extraction and liquid chromatography-positive electrospray ionization tandem mass spectrometry. J Chromatogr A 1218:1620–1631

    Article  CAS  PubMed  Google Scholar 

  6. Chiaia AC, Banta-Green C, Field J (2008) Eliminating solid phase extraction with large-volume injection LC/MS/MS: analysis of illicit and legal drugs and human urine indicators in U.S. wastewaters. Environ Sci Technol 42:8841–8848

    Article  CAS  PubMed  Google Scholar 

  7. Zuccato E, Chiabrando C, Castiglioni S, Calamari D, Bagnati R, Schiarea S, Fanelli R (2005) Cocaine in surface waters: a new evidence-based tool to monitor community drug abuse. Environ Health 4:14

    Article  PubMed  PubMed Central  Google Scholar 

  8. Postigo C, Alda ML, Barcelo D (2008) Analysis of drugs of abuse and their human metabolites in waterbyLC-MS2: a non-intrusive tool for drug abuse estimation at the community level. Trends Anal Chem 27:1053–1069

    Article  CAS  Google Scholar 

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Correspondence to Bikram Subedi .

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Foppe, K.S., Subedi, B. (2018). Analysis of Illicit Drugs in Wastewater Using High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (HPLC-ESI-MS/MS). In: Musah, R. (eds) Analysis of Drugs of Abuse. Methods in Molecular Biology, vol 1810. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8579-1_16

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  • DOI: https://doi.org/10.1007/978-1-4939-8579-1_16

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8578-4

  • Online ISBN: 978-1-4939-8579-1

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