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In Vivo 1H Magnetic Resonance Spectroscopy

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Preclinical MRI

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1718))

Abstract

In vivo Magnetic Resonance Spectroscopy (MRS) allows the non-invasive detection and quantification of a number of metabolites from localized volumes within a living organism. MRS localization techniques can be divided into two main groups, single voxel and multi-voxel. Single voxel techniques provide the metabolic profile from a specific small volume, whereas multi-voxel techniques are used to obtain the spatial distribution of metabolites throughout a large volume subdivided into small contiguous voxels. This chapter describes standard protocols for the acquisition and processing of in vivo single voxel1H MRS data from the rodent brain.

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Acknowledgements

The MRI system used in this work has been funded by the Spanish Ministry of Science and Innovation (National Plan for Scientific Research, Development and Technological Innovation 2008-2011) and the European Regional Development Fund (PCT-420000-2010-3).

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Authors and Affiliations

  1. BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain

    M. Carmen Muñoz-Hernández & María Luisa García-Martín

  2. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Málaga, Spain

    María Luisa García-Martín

Authors
  1. M. Carmen Muñoz-Hernández
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  2. María Luisa García-Martín
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Corresponding author

Correspondence to María Luisa García-Martín .

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Editors and Affiliations

  1. BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain

    María Luisa García Martín

  2. Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC/UAM, Madrid, Spain

    Pilar López Larrubia

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Muñoz-Hernández, M.C., García-Martín, M.L. (2018). In Vivo 1H Magnetic Resonance Spectroscopy. In: García Martín, M., López Larrubia, P. (eds) Preclinical MRI. Methods in Molecular Biology, vol 1718. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7531-0_10

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  • DOI: https://doi.org/10.1007/978-1-4939-7531-0_10

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7530-3

  • Online ISBN: 978-1-4939-7531-0

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