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Hepatocyte Transplantation pp 319–362Cite as

Creation of Three-Dimensional Liver Tissue Models from Experimental Images for Systems Medicine

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1506))

Abstract

In this chapter, we illustrate how three-dimensional liver tissue models can be created from experimental image modalities by utilizing a well-established processing chain of experiments, microscopic imaging, image processing, image analysis and model construction. We describe how key features of liver tissue architecture are quantified and translated into model parameterizations, and show how a systematic iteration of experiments and model simulations often leads to a better understanding of biological phenomena in systems biology and systems medicine.

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Acknowledgments

The presented work was supported by DFG (HO4772/1-1), BMBF (Virtual Liver Network, Lebersimulator, LiSyM), and ANR (iFlow).

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Authors and Affiliations

  1. Institute for Computer Science, University of Leipzig, Haertelstraße 16-18, 04107, Leipzig, Germany

    Stefan Hoehme & Adrian Friebel

  2. Molecular Hepatology, Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

    Seddik Hammad

  3. Department of Forensic Medicine and Veterinary Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt

    Seddik Hammad

  4. INRIA, Unit Rocquencourt B.P.105, 78153 Le Chesnay Cedex-France, Laboratoire Jacques-Louis Lions, France Université of Paris 06, CNRS UMR 7598, 4 pl. Jussieu, Paris, France

    Dirk Drasdo

  5. Leibniz Research Centre for Working Environment and Human Factors (IfADo), TU Dortmund University, Dortmund, Germany

    Jan G. Hengstler

Authors
  1. Stefan Hoehme
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  2. Adrian Friebel
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  3. Seddik Hammad
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  4. Dirk Drasdo
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  5. Jan G. Hengstler
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Corresponding author

Correspondence to Stefan Hoehme .

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Editors and Affiliations

  1. Department of Surgery, University of Leipzig, Leipzig, Germany

    Peggy Stock

  2. Department of Surgery, University of Leipzig, Leipzig, Germany

    Bruno Christ

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Hoehme, S., Friebel, A., Hammad, S., Drasdo, D., Hengstler, J.G. (2017). Creation of Three-Dimensional Liver Tissue Models from Experimental Images for Systems Medicine. In: Stock, P., Christ, B. (eds) Hepatocyte Transplantation. Methods in Molecular Biology, vol 1506. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6506-9_22

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  • DOI: https://doi.org/10.1007/978-1-4939-6506-9_22

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6504-5

  • Online ISBN: 978-1-4939-6506-9

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