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Apoptosis Methods in Toxicology pp 231–237Cite as

Liposomes in Apoptosis Induction and Cancer Therapy

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Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

Cancer is the leading cause of death with multiple obstacles in therapeutic arsenals employed to date. Apoptosis induction in cancer cells has hitherto been a prominent unresolved obstacle for a few decades. Liposomes with multiple merits were extensively employed to entrap several types of anticancer agents, biomolecules and imaging agents to achieve substantial therapeutic effect for various types of cancers. Multifunctional liposomes with enhanced biocompatible properties were designed to enhance the therapeutic effect. Despite the promising drug delivery strategies and significantly reduced toxicity of the liposomal formulations a few demerits still limit their success considerably. This chapter reviews recent advances in liposomal formulations, methods of therapeutic loaded liposomal preparation, their merits and demerits. A few challenges associated with liposomal drug delivery and apoptosis induction are also summarized.

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Acknowledgements

The authors sincerely thank Professor Dr. Yukio Nagasaki, Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, Japan for this generous support.

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Authors and Affiliations

  1. Department of Materials Science, Graduate School of Pure and Applied Sciences, Tsukuba University, Tsukuba, Ibaraki, 305-8573, Japan

    Magisetty Obulesu

  2. Department of Biochemistry, Central Food Technological Research Institute, Mysore, India

    Magisetty Jhansilakshmi

Authors
  1. Magisetty Obulesu
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  2. Magisetty Jhansilakshmi
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Corresponding author

Correspondence to Magisetty Obulesu .

Editor information

Editors and Affiliations

  1. Department of Biology, North Carolina A&T State University, Greensboro, North Carolina, USA

    Perpetua M. Muganda

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Obulesu, M., Jhansilakshmi, M. (2016). Liposomes in Apoptosis Induction and Cancer Therapy. In: Muganda, P. (eds) Apoptosis Methods in Toxicology. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3588-8_13

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  • DOI: https://doi.org/10.1007/978-1-4939-3588-8_13

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3586-4

  • Online ISBN: 978-1-4939-3588-8

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