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Tips on How to Collect and Administer the Mesenchymal Stem Cell Secretome for Central Nervous System Applications

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Mesenchymal Stem Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1416))

Abstract

Human mesenchymal stem cells (hMSCs) have been proposed as possible therapeutic agents for central nervous system (CNS) disorders. Recently, it has been suggested that their effects are mostly mediated through their secretome, which contains a number of neuroregulatory molecules capable of increasing cell proliferation, differentiation, and survival in different physiological conditions. Here, we present an overview of the hMSC secretome as a possible candidate in the creation of new cell-free therapies, demonstrating the process of its collection and route of administration, focusing our attention on their effects in CNS regenerative medicine.

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Authors and Affiliations

  1. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, 4710-057, Portugal

    F. G. Teixeira, S. C. Serra & A. J. Salgado

  2. ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal

    F. G. Teixeira, S. C. Serra & A. J. Salgado

Authors
  1. F. G. Teixeira
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  2. S. C. Serra
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  3. A. J. Salgado
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Correspondence to A. J. Salgado .

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Editors and Affiliations

  1. Dept of Molecular Med,Unit of Cardiology, University of Pavia, PAVIA, Italy

    Massimiliano Gnecchi

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Teixeira, F.G., Serra, S.C., Salgado, A.J. (2016). Tips on How to Collect and Administer the Mesenchymal Stem Cell Secretome for Central Nervous System Applications. In: Gnecchi, M. (eds) Mesenchymal Stem Cells. Methods in Molecular Biology, vol 1416. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3584-0_27

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  • DOI: https://doi.org/10.1007/978-1-4939-3584-0_27

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3582-6

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