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Clinical Applications of Mass Spectrometry in Drug Analysis

Methods and Protocols

  • Book
  • © 2016

Overview

Editors:
  1. Uttam Garg

    1. Dept of Pathology & Lab Medicine, Children's Mercy Hospitals & Clinics, Kansas City, USA

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice form the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1383)

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About this book

This volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Chapters in the book cover a wide array of topics such as: quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma; quantitation of total Buprenorphine and Norbuprenorphine in Meconium; quantitation or Carisoprodol and Meprobamate in Urine; and quantitation of Tricyclic Antidepressants in Serum. Each chapter contains a brief introduction to the topic, clinical utility of the analyte(s), and useful notes to help laboratorians easily reproduce the protocols discussed. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and thorough, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, is a great resource for laboratorians who are already using mass spectrometry or thinking of introducing this technology to their laboratories.

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Table of contents (27 protocols)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology

    • Uttam Garg, Yan Victoria Zhang
    Pages 1-10

  3. Quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

    • Matthew H. Slawson, Kamisha L. Johnson-Davis
    Pages 11-19

  4. Quantitation of the Oral Anticoagulants Dabigatran, Rivaroxaban, Apixaban, and Warfarin in Plasma Using Ultra-Performance Liquid Chromatography with Tandem Mass Spectrometry (UPLC-MS/MS)

    • Jaime H. Noguez, James C. Ritchie
    Pages 21-27

  5. Simultaneous Quantitation of Lamotrigine, Levetiracetam, 10-Hydroxycarbazepine, Topiramate, and Zonisamide in Serum Using HPLC-MS/MS

    • Dean C. Carlow, Heng Shi, Ryan C. Schofield
    Pages 29-37

  6. Quantification of the Triazole Antifungal Compounds Voriconazole and Posaconazole in Human Serum or Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS)

    • Alejandro R. Molinelli, Charles H. Rose IV
    Pages 39-47

  7. Quantitation of Haloperidol, Fluphenazine, Perphenazine, and Thiothixene in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

    • Matthew H. Slawson, Kamisha L. Johnson-Davis
    Pages 49-57

  8. Quantitation of Total Buprenorphine and Norbuprenorphine in Meconium by LC-MS/MS

    • Stephanie J. Marin, Gwendolyn A. McMillin
    Pages 59-68

  9. Quantitation of Buprenorphine, Norbuprenorphine, Buprenorphine Glucuronide, Norbuprenorphine Glucuronide, and Naloxone in Urine by LC-MS/MS

    • Stephanie J. Marin, Gwendolyn A. McMillin
    Pages 69-78

  10. A Simple Liquid Chromatography Tandem Mass Spectrometry Method for Quantitation of Plasma Busulfan

    • Shuang Deng, Michael Kiscoan, Clint Frazee, Susan Abdel-Rahman, Jignesh Dalal, Uttam Garg
    Pages 79-87

  11. High-Throughput Quantitation of Busulfan in Plasma Using Ultrafast Solid-Phase Extraction Tandem Mass Spectrometry (SPE-MS/MS)

    • Loralie J. Langman, Darlington Danso, Enger Robert, Paul J. Jannetto
    Pages 89-95

  12. Quantification of 11-Carboxy-Delta-9-Tetrahydrocannabinol (THC-COOH) in Meconium Using Gas Chromatography/Mass Spectrometry (GC/MS)

    • Judy Peat, Brehon Davis, Clint Frazee, Uttam Garg
    Pages 97-103

  13. Quantitation of Carisoprodol and Meprobamate in Urine and Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

    • Matthew H. Slawson, Kamisha L. Johnson-Davis
    Pages 105-114

  14. Cetirizine Quantification by High-Performance Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

    • Ada Munar, Clint Frazee, Bridgette Jones, Uttam Garg
    Pages 115-120

  15. Quantification of Docetaxel in Serum Using Turbulent Flow Liquid Chromatography Electrospray Tandem Mass Spectrometry (TFC-HPLC-ESI-MS/MS)

    • Christopher A. Crutchfield, Mark A. Marzinke, William A. Clarke
    Pages 121-124

  16. Comprehensive Urine Drug Screen by Gas Chromatography/Mass Spectrometry (GC/MS)

    • Bheemraj Ramoo, Melissa Funke, Clint Frazee, Uttam Garg
    Pages 125-131

  17. Broad-Spectrum Drug Screening Using Liquid Chromatography-Hybrid Triple-Quadrupole Linear Ion Trap Mass Spectrometry

    • Judy Stone
    Pages 133-151

  18. High-Resolution Mass Spectrometry for Untargeted Drug Screening

    • Alan H. B. Wu, Jennifer Colby
    Pages 153-166

  19. Quantitation of Ethyl Glucuronide and Ethyl Sulfate in Urine Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

    • Matthew H. Slawson, Kamisha L. Johnson-Davis
    Pages 167-175

  20. Quantification of Hydroxychloroquine in Blood Using Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry (TFLC-MS/MS)

    • Allison B. Chambliss, Anna K. Füzéry, William A. Clarke
    Pages 177-184
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Editors and Affiliations

  • Dept of Pathology & Lab Medicine, Children's Mercy Hospitals & Clinics, Kansas City, USA

    Uttam Garg

Bibliographic Information

  • Book Title: Clinical Applications of Mass Spectrometry in Drug Analysis

  • Book Subtitle: Methods and Protocols

  • Editors: Uttam Garg

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-3252-8

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-3251-1Published: 11 December 2015

  • Softcover ISBN: 978-1-4939-8006-2Published: 26 February 2019

  • eBook ISBN: 978-1-4939-3252-8Published: 11 December 2015

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XV, 272

  • Number of Illustrations: 14 b/w illustrations, 27 illustrations in colour

  • Topics: Pharmacology/Toxicology

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