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Disease Recurrence After Liver Transplantation pp 91–103Cite as

Recurrence of Autoimmune Hepatitis After Liver Transplantation

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Abstract

AIH may recur in the allograft as there is variation in the use of protocol biopsies and in the clinical, serological and histological criteria for the diagnosis, the reported incidence varies but recurrence may occur in around one third of patients at a median time of around 2–3 years but may occur as late as 10 years after transplant. Treatment of recurrent disease with the addition or increase in corticosteroids is often successful, although long-term data are lacking and some may progress to graft failure despite increased treatment.

A similar condition to autoimmune hepatitis may develop in the graft of those grafted for other indications. Originally termed de novo autoimmune hepatitis, some now believe this is better termed plasma cell hepatitis and is a form of rejection. Treatment is with corticosteroids or modification of immunosuppression.

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Authors and Affiliations

  1. Liver Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK

    James Neuberger D.M., F.R.C.P.

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  1. James Neuberger D.M., F.R.C.P.
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Correspondence to James Neuberger D.M., F.R.C.P. .

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Editors and Affiliations

  1. Institute for Digestive Health & Liver Disease, Mercy Medical Center & University of Maryland School of Medicine, Baltimore, Maryland, USA

    Paul J. Thuluvath

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Neuberger, J. (2016). Recurrence of Autoimmune Hepatitis After Liver Transplantation. In: Thuluvath, P. (eds) Disease Recurrence After Liver Transplantation. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2947-4_6

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  • DOI: https://doi.org/10.1007/978-1-4939-2947-4_6

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  • Print ISBN: 978-1-4939-2946-7

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