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The Role of Coagulation Factor Signaling in Angiogenesis and Vascular Remodeling

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Abstract

This chapter provides an overview on the signaling function of the clotting system. Coagulation proteases can activate protease-activated receptors (PARs) and the coagulation initiator tissue factor (TF) orchestrates many of these signaling processes. The current view of the hemostatic system with focus on the coagulation cascade as a serine protease network will be delineated and the activation mechanism of PARs is explained. This chapter provides an overview of the roles of the coagulation system during embryonic development of the vascular system by describing vascular phenotypes observed in mouse models of coagulation factor or PAR deficiency. In addition, the complex interplay of coagulation factor signaling and coagulation factor-dependent effects on the induction of angiogenic and vasoactive factors are described. Together, this chapter aims to provide an overview on how coagulation factor signaling is involved in physiologic and pathologic processes.

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Authors and Affiliations

  1. Center for Thrombosis and Hemostasis, University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany

    Dr. rer. biol. hum. Christoph Reinhardt, Dr. med. Davit Manukyan & Prof. Dr. med. Wolfram Ruf

  2. Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany

    Dr. med. Davit Manukyan

  3. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA

    Prof. Dr. med. Wolfram Ruf

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  1. Dr. rer. biol. hum. Christoph Reinhardt
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  2. Dr. med. Davit Manukyan
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  1. Microscopic Anatomy and Neurobiology Building 708, 2.Floor, R2.006, Johannes Gutenberg University School of Medicine, Mainz, Germany

    Mirko HH Schmidt

  2. Institute of Neurology Building 89, 4.Floor, R402, Goethe University Frankfurt School of Medicine, Frankfurt, Germany

    Stefan Liebner

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Reinhardt, C., Manukyan, D., Ruf, W. (2015). The Role of Coagulation Factor Signaling in Angiogenesis and Vascular Remodeling. In: Schmidt, M., Liebner, S. (eds) Endothelial Signaling in Development and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2907-8_10

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