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Vaginal and Rectal HIV Transmission in Humanized Mice

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Humanized Mice for HIV Research

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Abstract

Mucosal HIV exposures account for the vast majority of the 2.5 million new HIV transmissions that occur annually worldwide. The ability to accurately model mucosal HIV transmission in vivo using animal models such as humanized mice is important for understanding this process. Humanized mice have shown to be susceptible to HIV infection after either vaginal or rectal exposure and have been utilized for a number of mucosal transmission studies with primary HIV isolates, laboratory HIV isolates and, more recently, transmitted founder HIV isolates. Many studies of mucosal HIV transmission in humanized mice have focused on testing prevention, interventions, as well as the transmission of antiviral drug-resistant strains. The breadth of the studies reviewed here emphasizes the versatility of these models for future research evaluating mucosal HIV transmission and its prevention.

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Acknowledgment

This work was supported in part by National Institutes of Health grants AI73146 and AI96138 (JVG).

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Medicine, UNC Center for AIDS Research, University of North Carolina School of Medicine, Genetic Medicine Building 2046, 27599-7042, Chapel Hill, NC, USA

    Paul W. Denton, Morgan L. Chateau & J. Victor Garcia

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  1. Paul W. Denton
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  2. Morgan L. Chateau
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  3. J. Victor Garcia
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Corresponding author

Correspondence to Paul W. Denton .

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Editors and Affiliations

  1. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA

    Larisa Y. Poluektova

  2. Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

    J. Victor Garcia

  3. Research Center for AIDS Laboratory of Viral Pathogenesis, Kyoto University Institute for Virus Research, Sakyo-ku, Japan

    Yoshio Koyanagi

  4. Division of Hematology, University Hospital Zürich, Zürich, Switzerland

    Markus G. Manz

  5. Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA

    Andrew M. Tager

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Denton, P., Chateau, M., Garcia, J. (2014). Vaginal and Rectal HIV Transmission in Humanized Mice. In: Poluektova, L., Garcia, J., Koyanagi, Y., Manz, M., Tager, A. (eds) Humanized Mice for HIV Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1655-9_19

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