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Pseudogene-Derived Endogenous siRNAs and Their Function

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Pseudogenes

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1167))

Abstract

Pseudogenes were once considered genomic fossils, but recent studies indicate that they may function as gene regulators through the generation of endogenous small interfering RNAs (esiRNAs), antisense RNAs, and decoys for microRNAs. In this review, we summarize pseudogene study methods, emphasizing relevant publicly available resources, and we describe a systematic pipeline to identify pseudogene-derived esiRNAs and their targets, which can lead to a deeper understanding of pseudogene function.

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Acknowledgements

We thank the editor for her extensive comments that helped us to improve this manuscript. This work was supported by Asia University and a grant from the National Science Council of the Republic of China (NSC99-2320-B-037-006-MY3 to J.G.C.).

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Authors and Affiliations

  1. Biomedical Informatics, Asia University, Taichung, Taiwan

    Wen-Ling Chan

  2. Epigenome Research Center, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung, Taiwan

    Wen-Ling Chan & Jan-Gowth Chang M.D.

  3. School of Medicine, China Medical University, Taichung, Taiwan

    Wen-Ling Chan & Jan-Gowth Chang M.D.

  4. Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan

    Jan-Gowth Chang M.D.

  5. Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

    Jan-Gowth Chang M.D.

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  1. Wen-Ling Chan
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Correspondence to Jan-Gowth Chang M.D. .

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  1. Istituto Toscano Tumori, Pisa, Italy

    Laura Poliseno

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Chan, WL., Chang, JG. (2014). Pseudogene-Derived Endogenous siRNAs and Their Function. In: Poliseno, L. (eds) Pseudogenes. Methods in Molecular Biology, vol 1167. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0835-6_15

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  • DOI: https://doi.org/10.1007/978-1-4939-0835-6_15

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