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Introduction to Oxidative Stress and Antioxidant Therapy in Respiratory Disorder

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Abstract

Impairments of redox balance are presently known to be involved in many aspects of respiratory disorders. these are responsible for either acute or chronic events of damage in cells and tissues, thus leading to oxidative stress. The control of thiol redox in a number of signaling and transcriptional elements provides a fundamental regulatory role to cellular reactive oxygen species (ROS). These are for instance key players of the inflammatory signaling and participate in the remodeling of stressed tissues by differentiation, apoptosis, and autophagy of cellular components. New clues are also emerging on the role of ROS as pacesetters of metabolic pathways and aging of the entire organism. Besides the direct oxidant effects on cellular constituents, the alterations of these and other physiological roles of ROS can further contribute to develop oxidative stress. In this respect, the investigation of novel oxidative stress biomarkers may have translational impact on clinical monitoring of chronic respiratory diseases such as chronic obstructive pulmonary disease, bronchial asthma, and cystic fibrosis, also paving the way for the identification of innovative antioxidant therapies.

This introduction wishes to open the readers’ interest on these issues that are further expanded in the following chapters of this book dealing with oxidative stress mechanisms and remedies for specific respiratory diseases.

For the “Working Group on Inflammation in Cystic Fibrosis” of the Italian Society for Cystic Fibrosis and the Italian Cystic Fibrosis Research Foundation.

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Acknowledgments

The authors are grateful to the Italian Society for Cystic Fibrosis and the Italian Cystic Fibrosis Research Foundation for support, and all the other members of the Italian Working Group on Inflammation in Cystic Fibrosis (Alessandra Bragonzi, Elena Bravo, Salvatore Cuzzocrea, Maria Cristina Dechecchi, Alessandra De Alessandri, Virgilio Evangelista, Vincenzina Lucidi, Antonietta Lambiase, Antonio Manca, Paola Melotti, Laura Minicucci, Andrea Motta, Donatella Pietraforte, Alfonso Pompella, Serena Quattrucci, Roberta Rizzo, Roberto Rizzo, Mario Romano, Claudio Sorio, Riccardina Tesse) for helpful discussions.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy

    Francesco Galli, Desirée Bartolini, Marta Piroddi & Silvia Ciffolilli

  2. Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy

    Massimo Conese & Luigi Maiuri

  3. European Institute for Research in Cystic Fibrosis, Milan, Italy

    Luigi Maiuri

  4. Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy

    Roberto Gambari

  5. Department of Pathology and Diagnostics, University Hospital of Verona, Verona, Italy

    Giulio Cabrini

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  1. Francesco Galli
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Correspondence to Francesco Galli .

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  1. Department of Biotechnology, National Institute of Immunology, New Delhi, India

    Nirmal K. Ganguly

  2. Department of Pulmonary Medicine, Postgraduate Institute of Medical Educat, Chandigarh, India

    Surinder K. Jindal

  3. Department of Medicine and Oncology, Johns Hopkins College of Medicine, Baltimore, Maryland, USA

    Shyam Biswal

  4. National Heart & Lung Institute, Imperial College London, London, United Kingdom

    Peter J. Barnes

  5. Department of Pediatrics, Nippon Medical School, Tokyo, Japan

    Ruby Pawankar

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Galli, F. et al. (2014). Introduction to Oxidative Stress and Antioxidant Therapy in Respiratory Disorder. In: Ganguly, N., Jindal, S., Biswal, S., Barnes, P., Pawankar, R. (eds) Studies on Respiratory Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0497-6_1

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