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Wilms tumour and other genetic causes of renal cancer

  • Chapter
Genetic Predisposition to Cancer

Abstract

Primary cancers of the kidney are rare at any age. Although only a small proportion of cases are clearly inherited, genetic predisposition is the most important aetiological factor thus far identified in this group of tumours. The histological type of tumour depends very much on the age at tumour diagnosis; congenital mesoblastic nephroma is most common in the first 3 months of life, followed by a predominance of Wilms tumour (nephroblastoma) in early childhood which is overtaken by renal cell carcinoma in adult life. Kidney cancer is extremely rare between the ages of 7 and 40 years (see Figure 7.1).

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References

  1. Cardesa, A., Ribalta, T., Von, S.B. et al. (1989) Experimental model of tumors associated with neurofibromatosis. Cancer. 63 (9) 1737–49.

    Article  PubMed  CAS  Google Scholar 

  2. Breslow, N., Olshan, A., Beckwith, J.B. et al. (1993) Epidemiology of Wilms Tumor. Med. Pediatr. Oncol., 21 (3) 172–81.

    Article  PubMed  CAS  Google Scholar 

  3. Beckwith, J.B., Kiviat, N.B. and Bonadio, J.F. (1990) Nephrogenic rests, nephroblastomatosis and the pathogenesis of Wilms tumour. Pediatr. Pathol., 10, 1–36.

    Article  PubMed  CAS  Google Scholar 

  4. Knudson, A.G. and Strong, L.C. (1972) Mutation and cancer: a model for Wilms tumor of the kidney. J. Natl Cancer Inst., 48, 313–24.

    PubMed  Google Scholar 

  5. Goodrich, D.W. and Lee, W.-H. (1990) The molecular genetics of retinoblastoma. Cancer Surv., 9, 529–54.

    PubMed  CAS  Google Scholar 

  6. Maw, M., Grundy, P., Millow, L. et al. (1992) A third Wilms tumor locus on chromosome 16q. Cancer Res., 52, 3094–8.

    PubMed  CAS  Google Scholar 

  7. Haber, D.A., Buckler, A.J., Glaser, T. et al. (1990) An internal deletion within a 11p13 zinc finger gene contributes to the development of Wilms tumor. Cell, 61, (7) 1257–69.

    Article  PubMed  CAS  Google Scholar 

  8. Little, M.H., Prosser, J., Condie, A. et al. (1992) Zinc finger point mutations within the WT1 gene in Wilms tumor patients. Proc. Natl Acad. Sci. USA, 89 (11) 4791–5.

    Article  PubMed  CAS  Google Scholar 

  9. Knudson, A. (1980) Genetics and the child cured of cancer, In Status of the Curability of Childhood Cancers (eds J. van Eys and M.P. Sullivan), Raven Press, New York, p. 296.

    Google Scholar 

  10. Li F., Williams, W. Gimbere, K. et al. (1988) Heritable fraction of unilateral Wilms tumour. Pediatrics, 81, 147–9.

    PubMed  CAS  Google Scholar 

  11. Hawkins, M., Draper, G. and Smith, R.A. (1989) Cancer among 1,348 offspring of survivors of childhood cancer. Int. J. Cancer, 43, 975–8.

    Article  PubMed  CAS  Google Scholar 

  12. Byrne, J., Mulvihill, J., Connelly, R. et al. (1988) Reproductive problems and birth defects in survivors of Wilms tumour and their relatives. Med. Pediatr. Oncol., 16, 233–40.

    Article  PubMed  CAS  Google Scholar 

  13. Wiedemann, H.R. (1983) Tumours and hemihypetrophy associated with Wiedemann-Beckwith syndrome. Eur. J. Pediatr., 141, 129–36.

    Article  Google Scholar 

  14. Sotelo-Avila, C, Gonzalez-Crussi, F. and Fowler, J. (1980) Complete and incomplete forms of Beckwith — Wiedemann syndrome: their oncogenic potential. J. Pediatr., 96, 47–50.

    Article  PubMed  CAS  Google Scholar 

  15. Bonaïti-Pellié, C., Chompret, A., Tournade, M.-F. et al. (1993) Excess of multifocal tumours in nephroblastoma: implications for mechanisms of tumour development and genetic counselling. Hum. Genet., 91, 373–6.

    Article  PubMed  Google Scholar 

  16. Ton, C., Hirvonen, H., Miwa, H. et al. (1991) Positional cloning and characterisation of a paired box-and homeobox-containing gene from the aniridia region. Cell, 67, 1059–74.

    Article  PubMed  CAS  Google Scholar 

  17. Gessler, M., Poustka, A. Cavenee, W. et al. (1990) Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature, 343, 774–8.

    Article  PubMed  CAS  Google Scholar 

  18. Call, K.M., Glaser, T., Ito, C.Y. et al. (1990) Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms tumor locus. Cell, 60 (3), 509–20.

    Article  PubMed  CAS  Google Scholar 

  19. Van Heyningen, V., Bickmore, W.A., Seawright, A. et al. (1990) Role for the Wilms tumor gene in genital development? Proc. Natl Acad. Sci. USA, 87 (14), 5383–6.

    Article  PubMed  Google Scholar 

  20. Baird, P.N., Groves, N., Haber, D.A. et al. (1992) Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome. Oncogene, 7 (11), 2141–9.

    PubMed  CAS  Google Scholar 

  21. Brown, K.W., Watson, J.E., Poirier, V. et al. (1992) Inactivation of the remaining allele of the WT1 gene in a Wilms tumour from a WAGR patient. Oncogene, 7, 763–8.

    PubMed  CAS  Google Scholar 

  22. Gessler, M., König, A., Moore, J. et al. (1993) Homozygous inactivation of WT1 in a Wilms tumor associated with the WAGR syndrome. Genes Chromosom. Cancer, 7 (3) 131–6.

    CAS  Google Scholar 

  23. Park, S., Tomlinson, G., Nisen, P. et at. (1993) Altered trans-activational properties of a mutated WT1 gene product in a WAGR-associated Wilms tumour. Cancer Res., 53, 4757–60.

    PubMed  CAS  Google Scholar 

  24. Santos, A., Osorio, A.L., Baird, P.N., et al. (1993) Insertional inactivation of the WT1 gene in tumour cells from a patient with WAGR syndrome. Hum. Genet., 92 (1), 83–6.

    Article  PubMed  CAS  Google Scholar 

  25. Armstrong, J.F., Pritchard J.K., Bickmore, W. A. et al. (1993) The expression of the Wilms tumour gene, WT1, in the developing mammalian embryo. Mech. Dev., 40 (1-2), 85–97.

    Article  PubMed  CAS  Google Scholar 

  26. Pritchard-Jones, K., Fleming S., Davidson, D. et al. (1990) The candidate Wilms tumour gene is involved in genitourinary development. Nature, 346, 194–7.

    Article  PubMed  CAS  Google Scholar 

  27. Pelletier, J., Bruening, W., Kashtan, C.E., et al. (1991) Germline mutations in the Wilms tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. Cell, 67 (2), 437–47.

    Article  PubMed  CAS  Google Scholar 

  28. Little, M., Williamson, K., Mannens, M., et al. (1993) Evidence that WT1 mutations in Denys-Drash syndrome patients may act in a dominant-negative fashion. Hum. Mol. Genet., 2 (3), 259–64.

    Article  PubMed  CAS  Google Scholar 

  29. Bruening, W., Bardeesy, N., Silverman, B. et al. (1992) Germline intronic and exonic mutations in the Wilms tumour gene (WT1) affecting urogenital development. Nature Genet., 1, 144–8.

    Article  PubMed  CAS  Google Scholar 

  30. Coppes, M.J., Campbell, C.E. and Williams, B.R. (1993) The role of WT1 in Wilms tumorigenesis. FASEB J., 7 (10), 886–95.

    PubMed  CAS  Google Scholar 

  31. König, A., Jakubiczka, S., Wieacker, P. et al. (1993) Further evidence that imbalance of WT1 isoforms may be involved in Denys-Drash syndrome. Hum. Mol. Genet., 2, 1967–8.

    Article  PubMed  Google Scholar 

  32. Coppes, M., Liefers, G., Higuchi, M. et al. (1992) Inherited WT1 mutation in DDS. Cancer Res., 52, 6125–8.

    PubMed  CAS  Google Scholar 

  33. Baird, P.N., Santos, A., Groves, N. et al. (1992) Constitutional mutations in the WT1 gene in patients with Denys-Drash syndrome. Hum. Mol. Genet., 1 (5), 301–5.

    Article  PubMed  CAS  Google Scholar 

  34. Baird, P. and Cowell, J. (1993) A novel zinc finger mutation in a patient with Denys-Drash syndrome. Hum. Mol. Genet., 2, 2193–4.

    Article  PubMed  CAS  Google Scholar 

  35. Schneider, S., Wildhardt, G., Ludwig, R. et al. (1993) Exon skipping due to a mutation in a donor splice site in the WT-1 gene is associated with Wilms tumor and severe genital malformations. Hum. Genet., 91 (6), 599–604.

    Article  PubMed  CAS  Google Scholar 

  36. Sakai, A., Tadokoro, K., Yanagisawa, H. et al. (1993) A novel insertional mutation of the WT1 gene in a patient with Denys-Drash syndrome. Hum. Mol Genet., 2, 1969–70.

    Article  PubMed  CAS  Google Scholar 

  37. Ogawa, O., Eccles, M, Yun, K. et al. (1993) A novel insertional mutation at the third zinc finger coding region of the WT1 gene in Denys-Drash syndrome. Hum. Mol. Genet., 2, 203–4.

    Article  PubMed  CAS  Google Scholar 

  38. Nordenskjöld, A., Friedman, E. and Anvret, M. (1994) WT1 mutations in patients with Denys-Drash syndrome: a novel mutation in exon 8 and paternal allele origin. Hum Genet., 93, 115–20.

    Article  PubMed  Google Scholar 

  39. Clarkson, P., Davies, H., Williams, D. et al. (1993) Mutational screening of the Wilms tumour gene. WT1, in males with genital abnormalities. J.Med. Genet., 30, 767–72.

    Article  PubMed  CAS  Google Scholar 

  40. Akasaka, Y., Kikuchi, H., Nagai, T. et al. (1993) A point mutation found in the WT1 gene in a sporadic Wilms tumor without genitourinary abnormalities is identical with the most frequent point mutation in Denys-Drash syndrome. FEBS Lett., 317, 39–43.

    Article  PubMed  CAS  Google Scholar 

  41. Coppes, M.J., Liefers G.J., Paul, P. et al. (1993) Homozygous somatic WT1 point mutations in sporadic unilateral Wilms tumor. Proc. Natl Acad. Sci. USA, 90 (4), 1416–19.

    Article  PubMed  CAS  Google Scholar 

  42. Huff, V., Miwa, H., Haber, D.A. et al. (1991) Evidence for WT1 point Wilms tumor (WT) gene: intragenic germinal deletion in bilateral WT. Am. J. Hum. Genet., 48 (5), 997–1003.

    PubMed  CAS  Google Scholar 

  43. Tadokoro, K., Fujii, H., Ohshima, A. et al. (1992) Intragenic homozygous deletion of the WT1 gene in Wilms tumor. Oncogene, 7 (6), 1215–21.

    PubMed  CAS  Google Scholar 

  44. Pelletier, J., Bruening, W., Li, F.P. et al. (1991) WT1 mutations contribute to abnormal genital system development and hereditary Wilms tumour. Nature, 353, 431–4.

    Article  PubMed  CAS  Google Scholar 

  45. Wang, Z.Y., Qiu, Q.Q., Enger, K.T. et al. (1993) A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1. Proc. Natl Acad. Sci. USA, 90, 8896–900.

    Article  PubMed  CAS  Google Scholar 

  46. Wang, Z.Y., Qiu, Q.Q. and Deuel, T.F. (1993) The Wilms tumor gene product WT1 activates or suppresses transcription through separate functional domains. J. Biol. Chem., 268 (13), 9172–5.

    PubMed  CAS  Google Scholar 

  47. Kreidberg, J.A., Sariola, H., Loring, J.M. et al. (1993) WT-1 is required for early kidney development. Cell, 74 (4), 679–91.

    Article  PubMed  CAS  Google Scholar 

  48. Cowell, J.K., Wadey, R.B., Haber, D.A. et al. (1991) Structural rearrangements of the WT1 gene in Wilms tumour cells. Oncogene, 6 (4), 595–9.

    PubMed  CAS  Google Scholar 

  49. Kikuchi, H., Akasaka, Y., Nagai, T. et al. (1992) Genomic changes in the WT-gene (WT1) in Wilms tumors and their correlation with histology. Am. J. Pathol, 140 (4), 781–6.

    PubMed  CAS  Google Scholar 

  50. Radice, P., Pilotti, S., De, B.V. et al. (1993) Homozygous intragenic loss of the WT1 locus in a sporadic intralobar Wilms tumor [letter]. Int. J. Cancer, 55 (1), 174–6.

    Article  PubMed  CAS  Google Scholar 

  51. Ton, C.C., Huff, V., Call, K.M. et al. (1991) Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11 p13 zinc finger gene as the disease locus. Genomics, 10 (1), 293–7.

    Article  PubMed  CAS  Google Scholar 

  52. Drash, A., Sherman, F., Hartman, W. et al. (1970) A syndrome of pseudohermaphroditism. Wilms tumour, hypertension and degenerative renal disease. J. Pediatr, 76, 585–93.

    Article  PubMed  CAS  Google Scholar 

  53. Denys, P., Malvaux, P., Van den Berghe, H. et al. (1967) Association d’un syndrome anatomo-pathologique de pseudohermaphrodisme masculin, d’une tumeur de Wilms, d’une nephropathie parenchymateuse et d’un mosaicisms XX/XY. Arch. Fr. Pediatr., 24, 729–39.

    PubMed  CAS  Google Scholar 

  54. Jadresic, L., Bleake, J., Gordon, I. et al. (1990) Clinico-pathological review of 13 children with nephropathy, Wilms tumour and genital abnormalities (DRASH syndrome). J. Pediatr., 117, 717–25.

    Article  PubMed  CAS  Google Scholar 

  55. Hastie, N.D. (1992) Dominant negative mutations in the Wilms tumour (WT1) gene cause Denys-Drash syndrome — proof that a tumour-suppressor gene plays a crucial role in normal genitourinary development. Hum. Mol Genet., 1 (5), 293–5.

    Article  PubMed  CAS  Google Scholar 

  56. Henry, I., Hoovers, J., Barichard, F. et al. (1993) Pericentric intrachromosomal insertion responsible for recurrence of del(11)(p13p14) in a family. Genes Chromosom. Cancer, 7 (1), 57–62.

    Article  PubMed  CAS  Google Scholar 

  57. Pettenati, M.J., Haynes, J.L., Wappmer, R. et al. (1986) Wiedemann-Beckwith syndrome: presentation of clinical and psychogenetic data on 22 new cases and review of the literature. Hum. Genet., 71, 143–54.

    Article  Google Scholar 

  58. Moutou, C, Junien, C, Henry, I. et al. (1992) Beckwith-Wiedmann syndrome: a demonstration of the mechanisms responsible for the excess of transmitting females. J. Med. Genet., 29, 217–20.

    Article  PubMed  CAS  Google Scholar 

  59. Ohlsson, R., Nyström, A., Pfeifer-Ohlsson, S. et al. (1993) IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedmann syndrome. Nature Genet. 4, 94–7.

    Article  PubMed  CAS  Google Scholar 

  60. Ogawa, O., Eccles, M.R., Szeto, J. et al. (1993) Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms tumour. Nature, 362, 749–51.

    Article  PubMed  CAS  Google Scholar 

  61. Ogawa, O., Becroft, D., Morison, I. et al. (1993) Constitutional relaxation of insulin-like growth factor II gene imprinting associated with Wilms tumour and gigantism. Nature Genet., 5, 408–12.

    Article  PubMed  CAS  Google Scholar 

  62. Dao, D., Schroeder, W.T., Chao, L. et al. (1987) Genetic mechanisms of tumor-specific loss of 11p DNA sequences in Wilms tumor. Am. J. Hum. Genet., 41, 202–17.

    PubMed  CAS  Google Scholar 

  63. Hamel, B., Mannens, M. and Bökkerink, J. (1990) Perlman syndrome: a report of a case and results of molecular studies. Am. J. Hum. Genet., 45 (4), A48.

    Google Scholar 

  64. Neri, G., Martini-Neri, M., Katz, B. et al. (1984) The Perlman syndrome: familial renal dysplasia with Wilms tumor, fetal gigantism and multiple congenital anomalies. Am. J. Med. Genet., 19, 195–207.

    Article  PubMed  CAS  Google Scholar 

  65. Greenberg, F., Copeland, K. and Gresik, M. (1988) Expanding the spectrum of Perlman syndrome. Am. J. Med. Genet., 29, 773–6.

    Article  PubMed  CAS  Google Scholar 

  66. Perlman, M., Levin, M. and Witteis, B. (1975) Syndrome of fetal gigantism, renal hamartomas and nephroblastomatosis with Wilms tumour. Cancer, 35, 1212–17.

    Article  PubMed  CAS  Google Scholar 

  67. Grundy, R.G., Pritchard, J., Baraitser, M. et al. (1992) Perlman and Wiedemann-Beckwith syndromes: two distinct conditions associated with Wilms tumour. Eur. J. Pediatr., 151 (12), 895–8.

    Article  PubMed  CAS  Google Scholar 

  68. Stay, E. and Vawter, G. (1977) The relationship between nephroblastomata and neuro-fibromatosis. Cancer, 39, 2550–5.

    Article  PubMed  CAS  Google Scholar 

  69. Blatt, J., Jaffe, R., Deutsch, M. et al. (1986) Neurofibromatosis and childhood tumours. Cancer, 57, 1225–9.

    Article  PubMed  CAS  Google Scholar 

  70. Perilongo, G., Felix, C.A., Meadows, A.T. et al. (1993) Sequential development of Wilms tumor, T-cell acute lymphoblastic leukemia, medulloblastoma and myeloid leukemia in a child with type 1 neurofibromatosis: a clinical and cytogenetic case report. Leukemia, 7 (6), 912–15.

    PubMed  CAS  Google Scholar 

  71. Hartley, A.L., Birch, J.M., Tricker, K. et al. (1993) Wilms tumor in the Li-Fraumeni cancer family syndrome. Cancer Genet. Cytogenet., 67 (2), 133–5.

    Article  PubMed  CAS  Google Scholar 

  72. Clericuzio, C.L. (1993) Clinical phenotypes and Wilms tumor. Med. Pediatr. Oncol., 21, 182–7.

    Article  PubMed  CAS  Google Scholar 

  73. Pastore, G., Carli, M., Lemerle, J. et al. (1988) Epidemiological features of Wilms tumour: results of studies by the International Society of Paediatric Oncology (SIOP). Med. Pediatr. Oncol., 16, 7–11.

    Article  PubMed  CAS  Google Scholar 

  74. Huff, V., Compton, D.A., Chao, L.Y. et al. (1988) Lack of linkage of familial Wilms’ tumour to chromosomal band Hp13. Nature, 336, 377–8.

    Article  PubMed  CAS  Google Scholar 

  75. Schwartz, C.E., Haber, D.A., Stanton, V.P. et al. (1991) Familial predisposition to Wilms tumor does not segregate with the WT1 gene. Genomics, 10 (4), 927–30.

    Article  PubMed  CAS  Google Scholar 

  76. Huff, V., Reeve, A.E., Leppert, M. et al. (1992) Nonlinkage of 16q markers to familial predisposition to Wilms tumor. Cancer Res., 52 (21), 6117–20.

    PubMed  CAS  Google Scholar 

  77. Fantes, J., Bickmore, W., Fletcher, J. et al. (1992) Submicroscopic deletions at the WAGR locus, revealed by nonradioactive in situ hybridisation. Am. J. Hum. Genet., 51,1286–94.

    PubMed  CAS  Google Scholar 

  78. Baird, P., Pritchard, J. and Cowell, J. (1994) Molecular genetic analysis of chromosome 11p in familial Wilms tumour. Br. J. Cancer, 69, 1072–7.

    Article  PubMed  CAS  Google Scholar 

  79. Olson, J., Breslow, N. and Barce, J. (1993) Cancer in twins of Wilms tumour patients. Am. J. Med. Genet., 47, 91–4.

    Article  PubMed  CAS  Google Scholar 

  80. Green, D., Breslow, N., Beckwith, J.B. et al. (1993) Screening of children with hemihypertrophy, aniridia and Beckwith-Wiedemann syndrome in patients with Wilms tumour: a report from the National Wilms Tumor Study. Med. Paediatr. Oncol, 21, 188–92.

    Article  CAS  Google Scholar 

  81. Hawkins, M., Draper, G. and Kingston, J. (1987) Incidence of second primary tumours among childhood cancer survivors. Br. J. Cancer, 56, 339–47.

    Article  PubMed  CAS  Google Scholar 

  82. Austin, M.B., Fechner, R.E. and Roggli, V.L. (1986) Pleural malignant mesothelioma following Wilms tumour. Am. J. Clin. Pathol., 86, 227–30.

    PubMed  CAS  Google Scholar 

  83. Park, S., Schalling, M., Bernard, A. et al. (1993) The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma. Nature Genet., 4 (4), 415–20.

    Article  PubMed  CAS  Google Scholar 

  84. Pritchard-Jones, K., Renshaw, J. and King-Underwood, L. (1994) The Wilms tumour (WT1) gene is mutated in a secondary leukaemia in a WAGR patient. Hum. Molec. Genet., 3, 1633–7.

    Article  PubMed  CAS  Google Scholar 

  85. Whelan, S.L., Parkin, D.M. and Masuyer, E. (eds) (1990) Patterns of Cancer in Five Continents, vol. 102, International Agency for Research on Cancer, Lyon.

    Google Scholar 

  86. Coleman, M.P., Esteve, J., Damiecki, P. et al. (eds) (1993) Trends in Cancer Incidence and Mortality, vol. 121, IARC, Lyon.

    Google Scholar 

  87. Erlandsson, R., Boldog, F., Sumegi, J. et al. (1988) Do human renal cell carcinomas arise by a double-loss mechanism? Cancer Genet. Cytogenet., 36, 197–202.

    Article  PubMed  CAS  Google Scholar 

  88. Cohen, A.J., Li, F.P., Berg, S. et al. (1979) Hereditary renal cell carcinoma associated with a chromosomal translocation. N. Engl. J. Med., 301, 592–5.

    Article  PubMed  CAS  Google Scholar 

  89. Kovacs, G., Brusa, P. and De Riese, W. (1989) Tissue-specific expression of a constitutional 3;6 translocation: development of multiple bilateral renal cell carcinomas. Int. J. Cancer, 43, 422–7.

    Article  PubMed  CAS  Google Scholar 

  90. Yamakawa, K., Morita, R., Takahashi, E. et al. (1991) A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Res., 51, 4707–11.

    PubMed  CAS  Google Scholar 

  91. Yamakawa, K., Takahashi, E., Murata, M. et al. (1992) Detailed mapping around the breakpoint of the (3;8) translocation in familial renal cell carcinoma and FRA3B. Genomics, 14, 412–16.

    Article  PubMed  CAS  Google Scholar 

  92. Pathak, S., Strong, L.C., Ferrell, R.E. et al. (1982) Familial renal cell carcinoma with a 3; 11 chromosome translocation limited to tumour cells. Science, 217, 939–41.

    Article  PubMed  CAS  Google Scholar 

  93. Kovacs, G. and Hoene, E. (1988) Loss of der (3) in renal carcinoma cells of a patient with constitutional t(3;12). Human Genet., 78, 148–50.

    Article  CAS  Google Scholar 

  94. Li, F.P., Decker, H.-J.H., Zbar, B. et al. (1993) Clinical and genetic studies of renal cell carcinomas in a family with a constitutional chromosome 3;8 translocation. Ann. Intern. Med., 118, 106–11.

    Article  PubMed  CAS  Google Scholar 

  95. Gnarra, J.R, Tory, K., Weng, Y. et al. (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma. Nature Genet., 7, 85–9.

    Article  PubMed  CAS  Google Scholar 

  96. Shimizu, M., Yokota, J., Mori, N. et al. (1990) Introduction of a normal chromosome 3p modulates the tumorigenicity of a human renal cell carcinoma cell line YCR. Oncogene, 5, 185–94.

    PubMed  CAS  Google Scholar 

  97. Kantor, A.F. (1982) Hereditary renal carcinoma and chromosomal defects. N. Engl. J. Med., 307 (22), 1403–4.

    PubMed  CAS  Google Scholar 

  98. Walter, T.A., Berger, C.S. and Sandberg, A.A. (1989) The cytogenetics of renal tumours. Cancer Genet. Cytogenet., 43, 15–34.

    Article  PubMed  CAS  Google Scholar 

  99. Kovacs, G. (1993) Molecular differential pathology of renal cell tumours. Histopathology, 22, 1–8.

    Article  PubMed  CAS  Google Scholar 

  100. Morita, R., Saito, S., Ishikawa, J. et al. (1991) Common regions of deletion on chromosomes 5q, 6q and 10q in renal cell carcinoma. Cancer Res., 51, 5817–20.

    PubMed  CAS  Google Scholar 

  101. Ogawa, O., Habuchi, T., Kakehi, Y. et al. (1992) Allelic losses at chromosome 17p in human renal cell carcinoma are inversely related to allelic losses at chromosome 3p. Cancer Res., 52, 1881–5.

    PubMed  CAS  Google Scholar 

  102. Teyssier, J., Henry, I., Dozier, C. et al. (1986) Recurrent deletion of the short arm of chromosome 3 in human renal cell carcinoma: shift of the c-raf 1 locus. J. Natl Cancer Inst., 77, 1187–94.

    PubMed  CAS  Google Scholar 

  103. Maher, E.R. and Yates, J.R.W. (1991) Familial renal cell carcinoma: clinical and molecular genetic aspects. Br. J. Cancer, 63, 176–9.

    Article  PubMed  CAS  Google Scholar 

  104. Latif, F., Tory, K., Gnarra J. et al. (1993) Identification of the von Hippel-Lindau disease tumor suppressor gene. Science, 260, 1317–20.

    Article  PubMed  CAS  Google Scholar 

  105. Kovacs, G., Emanuel, A., Neumann, H. et al. (1993) Cytogenetics of renal cell carcinoma associated with von Hippel-Lindau disease. Genes Chromosom.,Cancer, 3, 256–62.

    Article  Google Scholar 

  106. Gomez, M.R. (1988) Tuberous Sclerosis. 2nd edn, Raven Press, New York.

    Google Scholar 

  107. Consortium ECITS. (1993) Identification and characterisation of the tuberous sclerosis gene on chromosome 16. Cell 75, 1305–15.

    Article  Google Scholar 

  108. Green, A. Smith, M. and Yates, J. (1994) Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nature Genet., 6, 193–6.

    Article  PubMed  CAS  Google Scholar 

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  1. Kathryn Pritchard-Jones
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Editors and Affiliations

  1. Cancer Genetics and Clinical Oncology, Institute of Cancer Research and Royal Marsden Hospital, Surrey, UK

    Rosalind A. Eeles (Senior Lecturer and Honorary Consultant) (Senior Lecturer and Honorary Consultant)

  2. CRC Human Cancer Genetics Research Group, University of Cambridge, UK

    Bruce A. J. Ponder (Director) (Director)

  3. CRC Genetic Epidemiology Unit, University of Cambridge, UK

    Douglas F. Easton (Director) (Director)

  4. Academic Unit of Radiotherapy and Oncology, Institute of Cancer Research and Royal Marsden Hospital, Surrey, UK

    Alan Horwich (Director of Clinical Research) (Director of Clinical Research)

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Pritchard-Jones, K. (1996). Wilms tumour and other genetic causes of renal cancer. In: Eeles, R.A., Ponder, B.A.J., Easton, D.F., Horwich, A. (eds) Genetic Predisposition to Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-4501-3_7

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  • DOI: https://doi.org/10.1007/978-1-4899-4501-3_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-56580-9

  • Online ISBN: 978-1-4899-4501-3

  • eBook Packages: Springer Book Archive

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