Abstract
Evidence has long accumulated that uremia is associated with defects in immune response capacity. Abnormalities in both T cell mediated immune responses and granulocyte production, kinetics and function have been reported in patients with end stage renal failure who were not yet dialysed or were undergoing long-term hemodialysis. Several hypotheses have been put forward to explain this state of immunodeficiency associated with chronic uremia and the changes in humoral and cellular immunity related to the hemodialysis procedure (recently reviewed in 1).
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Descamps-Latscha, B., Herbelin, A., Nguyen, A.T., Urena, P. (1991). Respective Influence of Uremia and Hemodialysis on Whole Blood Phagocyte Oxidative Metabolism, and Circulating Interleukin-1 and Tumor Necrosis Factor. In: Hörl, W.H., Schollmeyer, P.J. (eds) New Aspects of Human Polymorphonuclear Leukocytes. Advances in Experimental Medicine and Biology, vol 297. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3629-5_16
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DOI: https://doi.org/10.1007/978-1-4899-3629-5_16
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