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Urate Transport in the Proximal Tubule of Human Kidney

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 309A))

Abstract

Urate is transported bidirectionally by the renal proximal tubule of mammals. The direction of the net flux is, however, highly species dependent, so that some mammals are urate “reabsorbers” while others are urate “secreters” (Roch-Ramel and Weiner, 1980).

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References

  • Berner, W., and Kinne, R., 1976, Transport of p-aminohippuric acid by plasma membrane vesicles isolated from rat kidney cortex, Pflügers Arch., 361:269.

    Article  PubMed  CAS  Google Scholar 

  • Biber, J., Stieger, B., Haase, W., and Murer, H., 1981, A high yield preparation for rat kidney brush border membranes. Different behaviour of lysosomal markers, Biochim. Biophys. Acta, 647:169.

    Article  PubMed  CAS  Google Scholar 

  • Bradford, M.M., 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72:248.

    Article  PubMed  CAS  Google Scholar 

  • Guggino, S.E., Martin, G.J., and Aronson, P.S., 1983, Specificity and modes of the anion exchanger in dog renal microvillus membranes, Am.J. Physiol., 244:F612.

    PubMed  CAS  Google Scholar 

  • Haase, W., Schäfer, A., Murer, H., and Kinne, R., 1978, Studies on the orientation of brush-border membrane vesicles, Biochem.J., 172:57.

    PubMed  CAS  Google Scholar 

  • Kahn, A.M., and Weinman, E.J., 1985, Urate transport in the proximal tubule: in vivo and vesicle studies, Am.J. Physiol., 249:F789.

    PubMed  CAS  Google Scholar 

  • Martinez, F., Manganel, M., Montrose-Rafizadeh, C., Werner, D., and Roch-Ramel, F., 1990, Transport of urate and p-aminohippurate in rabbit renal brush-border membranes, Am.J. Physiol., 258:F1145.

    PubMed  CAS  Google Scholar 

  • Roch-Ramel, F., and Weiner, I.M., 1980, Renal excretion of urate: factors determining the actions of drugs, Kidney Int., 18:665.

    Article  PubMed  CAS  Google Scholar 

  • Werner, D., and Roch-Ramel, F., 1991, Indirect Na+ dependency of urate and p-aminohippurate transport in pig basolateral membrane vesicles, Am.J. Physiol., 261: in press.

    Google Scholar 

  • Werner, D., Martinez, F., and Roch-Ramel, F., 1990, Urate and p-aminohippurate transport in the brush border membrane of the pig kidney, J. Pharmacol. EXP. Ther., 252:792.

    PubMed  CAS  Google Scholar 

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© 1991 Springer Science+Business Media New York

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Werner, D., Guisan, B., Roch-Ramel, F. (1991). Urate Transport in the Proximal Tubule of Human Kidney. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2638-8_40

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  • DOI: https://doi.org/10.1007/978-1-4899-2638-8_40

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2640-1

  • Online ISBN: 978-1-4899-2638-8

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