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The Search for Antiparasitic Agents from Marine Animals

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Pharmaceutical and Bioactive Natural Products

Abstract

Infectious diseases caused by parasites occur in people (and animals) throughout the world. It is well known that improperly prepared pork can cause trichinosis, an intestinal infection by the helminth Trichinella spiralis. Hookworm disease is widespread throughout nearly all tropical and subtropical countries and is an infection of the small intestine by the helminth Necator americanus Campers often see warning signs that water in a nearby stream could be contaminated with the protozoan Giardia lamblia. Travelers to the deep tropics (as well as the natives) are advised to use prophylaxis to protect against malarial infections from Plasmodium parasites. These examples vividly illustrate the ubiquity of parasite diseases, which, in most cases, can be controlled by chemotherapy (Gutteridge, 1989b). There are well-known examples of clinically active antiparasitic agents derived from plant and fermentation sources (Hart et al., 1989; James and Gilles, 1985). Just beginning to emerge are marine natural products with activity against helminth and protozoal organisms. These will be the subject of our review.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, and Institute of Marine Sciences, University of California, Santa Cruz, California, 95064, USA

    Phil Crews & Lisa M. Hunter

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  1. Phil Crews
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  1. National Oceanic and Atmospheric Administration, Washington, D.C., USA

    David H. Attaway

  2. National Research Council, National Academy of Sciences, Washington, D.C., USA

    Oskar R. Zaborsky

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Crews, P., Hunter, L.M. (1993). The Search for Antiparasitic Agents from Marine Animals. In: Attaway, D.H., Zaborsky, O.R. (eds) Pharmaceutical and Bioactive Natural Products. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2391-2_9

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  • DOI: https://doi.org/10.1007/978-1-4899-2391-2_9

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