Abstract
Baculovirus multiplication culminates in high-level production of two temporally and morphologically distinct forms of infectious progeny (budded virus and occluded virus) in a process unique among animal viruses. Regulation of the 100 or more open reading frames required to accomplish productive infection is highly complex and involves sequential and coordinated expression of early, late, and very late genes. In the cascade of viral regulatory events, successive stages of virus replication are dependent on proper expression of genes within the preceding stage. Thus, critical to baculovirus replicative success is the appropriate expression and regulation of early genes. The products of early viral genes function to both accelerate replicative events and to prepare the host cell for virus multiplication, which represents an enormous tax on cellular biosynthetic capacity. Specific early genes are also essential for virus-mediated regulation of the host, including the control of larval molting and evasion of host antiviral responses such as apoptosis (see Chapters 10 and 11, this volume). Thus, early baculovirus genes collectively contribute to host range determination.
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Friesen, P.D. (1997). Regulation of Baculovirus Early Gene Expression. In: Miller, L.K. (eds) The Baculoviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1834-5_6
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