Abstract
Monocytes and macrophages play important roles in many host reactions. They can mediate immune and inflammation processes via the production and release of a variety of soluble mediators such as radicals like Superoxide anions (O2 −), cytokines like tumor necrosis factor a (TNF-α) and eicosanoids like prostaglandin E2 (PGE2). These biological active agents are also known to modulate cell differentiation and proliferation.
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References
Y. Tsuchiya, Y. Kabayashi, H. Goto, S. Okumura, T. Nakae, K. Konno and K. Tada, Induction of maturation in cultured human monocytic cells by a phorbol diester, Cancer Res. 42:1530 (1982).
Z. Bar-Shavit, S.L. Teitelbaum, P. Reitsma, A. Hall, L.E. Peg, J. Trias, and A. Khas, Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3, Proc. Natl. Acad. Sci. USA 80: 5907(1983).
S. Murao, M.A. Gemmel, M.F. Callaham, N.L. Anderson, and E. Huberman, Control of macrophage cell differentiation in human promyelocytic HL-60 cells by 1,25-dihydroxyvitamin D3 and phorbol 12-myristate 13-acetate, Cancer Res. 43: 4989 (1983).
I. Olsson, U. Gullberg, I. Ivhed, and K. Nilsson, Induction of differentiation of the human cell line U-937 by lα-4-dihydroxycholecalciferol, Cancer. Res. 43: 5862 (1983).
P. Dieter, P. Ambs, E. Fitzke, H. Hidaka, R. Hoffmann, and H. Schwende, Comparative studies of cytotoxicity and the release of TNF-α, nitric oxide, and eicosanoids of liver macrophages treated with lipopolysaccharide and liposome-encapsulated MTP-PE, J. Immunol. 155:2595 (1995).
P. Ambs, M. Baccarini, E. Fitzke, and P. Dieter, Role of cytosolic phospholipase A2 in arachidonic acid release of rat-liver macrophages: regulation by Ca2+ and phosphorylation, Biochem. J. 31:189 (1995).
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Schwende, H., Fitzke, E., Ambs, P., Dieter, P. (1997). Formation of Eicosanoids during Differentiation of Thp-1 Cells. In: Honn, K.V., Marnett, L.J., Nigam, S., Jones, R.L., Wong, P.YK. (eds) Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3. Advances in Experimental Medicine and Biology, vol 407. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1813-0_73
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DOI: https://doi.org/10.1007/978-1-4899-1813-0_73
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