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The Role of CD40 Ligand in Human Disease

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Mechanisms of Lymphocyte Activation and Immune Regulation V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 365))

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Abstract

CD40 is a 50kDA surface glycoprotein expressed predominantly on B cells, monocytes, dendritic cells, thymic epithelium and certain carcinomas.1–3 It is a member of the tumor necrosis factor receptor (TNFR) superfamily,4,5 a group of related type I transmembrane molecules which, in addition to CD40, includes both forms of TNFR, the low affinity nerve growth factor (NGF) receptor, CD27, CD30, OX40, 4-1BB, and Fas.6–9 Members of this family are characterized by the presence of multiple cysteine-rich repeats consisting of approximately 40 amino acids in the extracellular amino terminal domain.5 The average sequence homology between family members in the extracellular domain is around 25%.

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Author information

Authors and Affiliations

  1. Immunex Research and Development Corporation, Molecular Biology, Seattle, WA, 98101, USA

    Melanie K. Spriggs

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  1. Melanie K. Spriggs
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Editor information

Editors and Affiliations

  1. Department of Medicine, University of California, Irvine, CA, 92717-4069, USA

    Sudhir Gupta

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0001, USA

    William E. Paul

  3. Department of Microbiology and Immunology, University of California, San Francisco, CA, 94143-0552, USA

    Anthony DeFranco

  4. Department of Immunology, University of Washington, Seattle, WA, 98915, USA

    Roger M. Perlmutter

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Spriggs, M.K. (1994). The Role of CD40 Ligand in Human Disease. In: Gupta, S., Paul, W.E., DeFranco, A., Perlmutter, R.M. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation V. Advances in Experimental Medicine and Biology, vol 365. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0987-9_25

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  • DOI: https://doi.org/10.1007/978-1-4899-0987-9_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0989-3

  • Online ISBN: 978-1-4899-0987-9

  • eBook Packages: Springer Book Archive

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