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Circadian Rhythmicity

Regulation in the Time Domain

  • Chapter
Biological Regulation and Development

Abstract

The control of rate and of temporal sequence is a major aspect of biological regulation. Inferences about causality are often made on the basis of experimentally determined temporal sequence with the unstated assumption that the underlying temporal processes are linear. Because many biological processes oscillate (especially those with feedback regulation), the assumption of linearity is likely to be false, and the causal connections based on it will often be wrong. When the underlying temporal organization is oscillatory, then processes can appear to occur after the events that they cause. In cases that involve synchronization of oscillations, the regulatory cycle often “phase lags” the oscillation that it controls (Pittendrigh, 1981b). This example is meant only to illustrate the importance of understanding temporal frameworks.

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Authors and Affiliations

  1. Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, 60201, USA

    Joseph S. Takahashi

  2. Institute of Neuroscience, University of Oregon, Eugene, Oregon, 97403, USA

    Michael Menaker

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  1. Joseph S. Takahashi
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  2. Michael Menaker
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Editors and Affiliations

  1. Columbia University, New York, New York, USA

    Robert F. Goldberger

  2. University of California, San Francisco, San Francisco, California, USA

    Keith R. Yamamoto

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Takahashi, J.S., Menaker, M. (1984). Circadian Rhythmicity. In: Goldberger, R.F., Yamamoto, K.R. (eds) Biological Regulation and Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4619-8_8

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  • DOI: https://doi.org/10.1007/978-1-4757-4619-8_8

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