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Molar Pregnancies

  • Chapter
Pathology of the Human Placenta

Abstract

The term “gestational trophoblastic neoplasia” has become popular in recent years, although it comprises entities that are clearly not neoplastic, such as triploid partial moles. Driscoll (1981), in an excellent review of the morphology of these diseases, strongly favored abandonment of the time-honored term hydatidiform mole. Fox (1989) has added fuel to the fire by suggesting the following: “Is it, in fact, justifiable to continue distinguishing complete from partial moles in routine histopathological practice?” He based this opinion primarily on the exceptional finding of a single case of choriocarcinoma said to have followed a partial mole (Looi & Sivanesaratnam, 1981). This view is not ours. After all, choriocarcinoma is also an occasional sequela of an apparently normal gestation, as Fox readily conceded, and there may have been a choriocarcinomatous cell line ab initio. The typical hydatidiform mole (complete mole), syncytial endometritis, invasive moles (chorioadenoma destruens), benign metastasizing mole, the partial hydatidiform mole with or without fetus, and ectopic moles are discussed in this chapter. Their terminology is often confusing and imprecisely used. Choriocarcinoma is covered in Chapter 23.

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  1. University Medical Center, University of California, San Diego, 92103-8321, San Diego, California, USA

    Kurt Benirschke MD (Professor of Pathology and Reproductive Medicine)

  2. Institut für Anatomie der Medizinischen Fakultät, Rheinisch-Westfälische Technische Hochschule Aachen, 52057, Aachen, Germany

    Professor Dr. med. Peter Kaufmann

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Benirschke, K., Kaufmann, P. (1995). Molar Pregnancies. In: Pathology of the Human Placenta. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4196-4_22

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