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Dopamine Receptor-Mediated Gene Regulation in the Pituitary

  • Chapter
Book cover The Dopamine Receptors

Part of the book series: The Receptors ((REC))

Abstract

A common regulatory mechanism in the endocrine and neuroendocrine system is the coupling of secretion with the biosynthesis of a hormone. Factors that regulate hormone release also regulate its biosynthesis. This provides a cellular mechanism to ensure a ready supply of the protein or peptide. Thus, for any cell type in which secretion is regulated by dopamine via a dopamine receptor, it might be expected that dopamine would also have a significant effect on expression of the genes encoding the peptide/protein hormones themselves and/or those genes encoding the proteins involved in hormone production. Indeed, this linkage has been demonstrated in the first studies of regulation of prolactin and pro-opiomelanocortin (POMC) gene expression performed in model pituitary cell culture systems. Since these pituitary hormone-encoding genes were some of the first to be cloned in the early days of recombinant DNA technology, their regulation by dopamine has been well characterized but, surprisingly, some aspects of the underlying mechanisms have not been elucidated. In this chapter we discuss what is known about the expression of different dopamine receptor subtypes in the pituitary gland; their mechanisms of intracellular signaling; and processes by which the activation of these receptors interdicts the gene expression of two major pituitary peptide/protein hormone genes, prolactin and POMC.

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Authors
  1. James L. Roberts
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  2. Stuart C. Sealfon
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  3. Jean Philippe Loeffler
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Editor information

Editors and Affiliations

  1. Department of Behavioral Neuroscience, Oregon Health Sciences University and VA Medical Center, Portland, OR, USA

    Kim A. Neve

  2. Department of Genetics, Harvard Medical School, McLean Hospital, Belmont, MA, USA

    Rachael L. Neve

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© 1997 Springer Science+Business Media New York

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Roberts, J.L., Sealfon, S.C., Loeffler, J.P. (1997). Dopamine Receptor-Mediated Gene Regulation in the Pituitary. In: Neve, K.A., Neve, R.L. (eds) The Dopamine Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2635-0_11

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  • DOI: https://doi.org/10.1007/978-1-4757-2635-0_11

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-2637-4

  • Online ISBN: 978-1-4757-2635-0

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