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Biomechanical Transport Processes pp 347–356Cite as

The Influence of Vascular Smooth Muscle on the Development of Post-Stenotic Dilatation

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Part of the book series: NATO ASI Series ((NSSA,volume 193))

Summary

A segment of the thoracic aorta distal to a stenotic ring in four rabbits was frozen with liquid nitrogen in order to determine whether post-stenotic dilatation (PSD) would develop in the absence of viable vascular smooth muscle (VSM). Four animals were similarly prepared except that the rings did not constrict the aorta. Another four served as controls, having constricting rings but no aortic freezing. PSD developed as expected in the nonfrozen stenosed animals (60% diameter increase in 8 weeks). Freezing was associated with a rapid dilatation of the vessel when compared to the proximal segment (56% diameter increase) which regressed to normal dimensions during the next 8 weeks. In spite of marked fibrosis of the frozen areas their static elastic moduli did not differ significantly from that of their dilated counterparts, although in all cases the segments distal to the constriction had significantly greater modulus values than those proximal to it. The dynamic elastic modulus of the frozen segments was significantly greater than that of the PSD region and the untreated areas proximal to the stenosis site.

We conclude that destruction of VSM by freezing prevents the development of PSD and that this may be due in part to the increased dynamic stiffness of the frozen vessels.

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Author information

Authors and Affiliations

  1. Department of Morbid Anatomy, London Hospital, London, El 1BB, England

    S. E. Greenwald

  2. Department of Physiology, University of Sydney, Sydney, NSW, Australia

    U. Kukongviriyapan & B. S. Gow

Authors
  1. S. E. Greenwald
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  2. U. Kukongviriyapan
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  3. B. S. Gow
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Editor information

Editors and Affiliations

  1. Institut de Physique, Université de Liège, B5, Biophysique, 4000, Biomécanique Sart-Tilman, Liège, Belgium

    Florentina Mosora (Professor of Biophysics and Biomechanics) (Professor of Biophysics and Biomechanics)

  2. Physiological Flow Studies Unit, Imperial College, Prince Consort Road, SW7 2AZ, London, UK

    Colin G. Caro

  3. Aerodynamisches Institut, RWTH Aachen, Wülnerstrasse 5-7, 5100, Aachen, Deutschland

    Egon Krause

  4. Lehrstuhl für Physiologie, RWTH Aachen, Aachen, Germany

    Holger Schmid-Schönbein

  5. INSERM, Université de Bordeaux II, U306, Rue Léo Saignat 146, 33076, Bordeaux Cedex, France

    Charles Baquey

  6. Institut de Mécanique des Fluides, Groupe de Mécanique, Université d’ Aix Marseille II, Rue Honnorat 1, 13003, Marseille, France

    Robert Pelissier

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© 1990 Springer Science+Business Media New York

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Greenwald, S.E., Kukongviriyapan, U., Gow, B.S. (1990). The Influence of Vascular Smooth Muscle on the Development of Post-Stenotic Dilatation. In: Mosora, F., Caro, C.G., Krause, E., Schmid-Schönbein, H., Baquey, C., Pelissier, R. (eds) Biomechanical Transport Processes. NATO ASI Series, vol 193. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1511-8_37

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  • DOI: https://doi.org/10.1007/978-1-4757-1511-8_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1513-2

  • Online ISBN: 978-1-4757-1511-8

  • eBook Packages: Springer Book Archive

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