Abstract
5-Phosphoribosylpyrophosphate (PRPP) is a substrate of hypoxanthineguaninephosphoribosyltransferase (HGPRT) and adeninephosphoribosyltransferase (APRT). It stabilizes these purine phosphoribosyltransferases against thermal inactivation in vitro. Using sucrose density gradient ultracentrifugation we investigated whether this stabilisation is associated with a change in the configuration of these enzymes.
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© 1980 Plenum Press, New York
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Gröbner, W., Zöllner, N. (1980). The Effect of Phosphoribosylpyrophosphate on Stability and Configuration of Hypoxanthineguaninephosphoribosyltransferase and Adeninephosphoribosyltransferase from Human Erythrocytes. In: Rapado, A., Watts, R.W.E., De Bruyn, C.H.M.M. (eds) Purine Metabolism in Man—III. Advances in Experimental Medicine and Biology, vol 122B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8559-2_20
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DOI: https://doi.org/10.1007/978-1-4684-8559-2_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8561-5
Online ISBN: 978-1-4684-8559-2
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