Abstract
The number of sophisticated physical and mathematical systems that have been proposed to simulate the movement of oxygen from the environment to the cell probably equals (and may even exceed!) the number of investigators in this field. In terms of the problem with which we will deal in the next few pages, a much simpler model comes to mind. In this analogy, the integrated O2 transport to tissue is compared to a tree, in which nutrients are absorbed by finely ramified roots and transported by the sap to a similarly subdivided set of branches through which they reach the delivery site. The two ends of the chain, dissimilar as they may look, share an important requirement, namely the need for proper functional distribution: clearly the roots should not be evenly spaced, like the spokes of a wheel, but rather must be more heavily concentrated in the area where more food or water is available; likewise the sap flow must go preferentially to parts that require more nourishment.
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References
Carlisle, R., Lanphier, E. H., and Rahn, H., 1964, Hyperbaric oxygen and persistence of vision in retinal ischemia, J. Appl. Physiol., 19:914–918
Marshall, B. E., Marshall, C., Benumof, J., and Saidman, L. J., 1981, Hypoxic pulmonary vasoconstriction in dogs: effects of lung segment size and oxygen tension, J. Appl. Physiol: Resp., Environ. Exercise Physiol., 51:1543–1551
Robinson, S. M., Cadwallader, J. A., and McN. Hill, P. (1978), An animal model for the study of regional lung function, J. Appl Physiol: Resp., Environ. Exercise Physiol., 42:32–324
Sheehan, D. W., and Farhi, L. E., 1989, Local pulmonary vasoconstrictor response at different oxygenation levels. Proceedings of the XXXI Internat!. Cong. Physiol. Sci., Helsinki, Finland, p. 443
Sheehan, D. W., Klocke, R. A., and Farhi, L. E., 1988, Non-invasive on-line measurement of regional pulmonary hypoxic vasoconstriction in the conscious animal, Physiologist, 31: A195
Sylvester, J. T., Harabin, A. L., Peake, M. D., and Frank, R. S., 1980, Vasodilator and vasoconstrictor responses to hypoxia in isolated pig lungs, J. Appl. Physiol.: Respir., Environ., Exercise Physiol., 49:820–825
von Euler, U. S., and Liljestrand, G., 1946, Observations on the pulmonary arterial pressure in the cat, Acta Physiol. Scan., 12:301–320
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© 1990 Plenum Press, New York
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Farhi, L.E., Sheehan, D.W. (1990). Pulmonary Circulation and Systemic Circulation: Similar Problems, Different Solutions. In: Piiper, J., Goldstick, T.K., Meyer, M. (eds) Oxygen Transport to Tissue XII. Advances in Experimental Medicine and Biology, vol 277. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8181-5_65
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DOI: https://doi.org/10.1007/978-1-4684-8181-5_65
Publisher Name: Springer, Boston, MA
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